Effects of RYGB on energy expenditure, appetite and glycaemic control: a randomized controlled clinical trial (original) (raw)

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Acknowledgements

We thank Luise Gunvald, John Gargul Lind, Lene Stevner, Jane Jørgensen, Søren Andresen, Marianne Juul, Ulla Skovbæch Pedersen (all from the Department of Nutrition, Exercise and Sports, Denmark), Gitte Kølander Hansen (Novo Nordisk, Måløv, Denmark), Lene Albæk (MFI) for technical assistance and surgeons and the surgical staff (Hvidovre Hospital, Denmark). Except for Lind, Stevner, Jørgensen, Andresen, Juul and Pedersen, no financial compensation was given to the above-mentioned for their role in the study. The study was carried out as a part of UNIK: Food, Fitness and Pharma for Health and Disease at the University of Copenhagen. The UNIK project was funded by the Danish Ministry of Science, Technology and Innovation. Cambridge Weight Plan, UK provided the low-calorie diet products and Novo Nordisk A/S, DK supported costs of analysis of bile acids. The study was registered at ClinicalTrials.gov.

Author contributions

Dr Schmidt and Dr Sjödin had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis. Conception and design: Gregersen, Pedersen, Madsbad, Astrup, Holst, Sjödin, Worm, Hansen. Acquisition of data: Schmidt, Gregersen, Vestergaard, Søndergaard, Madsbad, Clausen, Holst, Rehfeld. Analysis and interpretation of data: Schmidt, Gregersen, Pedersen, Vestergaard, Søndergaard, Ritz, Madsbad, Clausen, Astrup, Holst, Sjödin, Rehfeld, Worm, Hansen. Drafting of the manuscript: Schmidt, Pedersen, Madsbad, Sjödin, Holst. Critical revision of the manuscript for important intellectual content: Schmidt, Gregersen, Pedersen, Vestergaard, Søndergaard, Ritz, Madsbad, Clausen, Astrup, Holst, Sjödin, Rehfeld, Worm, Hansen. Statistical analysis: Schmidt, Vestergaard, Søndergaard, Ritz. Obtained funding: Gregersen, Pedersen, Astrup, Holst, Sjödin, Worm, Hansen. Administrative, technical or material support: Schmidt, Clausen, Astrup, Sjödin, Rehfeld. Study supervision: Gregersen, Pedersen, Madsbad, Astrup, Holst, Sjödin. Final approval of the submitted manuscript: Schmidt, Gregersen, Pedersen, Vestergaard, Søndergaard, Ritz, Madsbad, Clausen, Astrup, Holst, Sjödin, Rehfeld, Worm, Hansen.

Author information

Author notes

  1. S D Pedersen & N T Gregersen
    Present address: 7Current address: Department of Nutrition, Exercise and Sports, Rolighedsvej 26, 1985 Frederiksberg C, Denmark.,

Authors and Affiliations

  1. Department of Nutrition, Exercise and Sports (NEXS), Faculty of Science, University of Copenhagen, Copenhagen, Denmark
    J B Schmidt, S D Pedersen, N T Gregersen, L Vestergaard, M S Nielsen, C Ritz, A Astrup & A Sjödin
  2. C-ENDO Endocrinology Clinic, Calgary, AB, Canada
    S D Pedersen
  3. Novo Nordisk A/S, Bagsværd, Denmark
    N T Gregersen & T R Clausen
  4. Department of Endocrinology, Hvidovre University Hospital, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark
    S Madsbad, D Worm & D L Hansen
  5. Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark
    J F Rehfeld
  6. NNF Center for Basic Metabolic Research and Department of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
    J J Holst

Authors

  1. J B Schmidt
  2. S D Pedersen
  3. N T Gregersen
  4. L Vestergaard
  5. M S Nielsen
  6. C Ritz
  7. S Madsbad
  8. D Worm
  9. D L Hansen
  10. T R Clausen
  11. J F Rehfeld
  12. A Astrup
  13. J J Holst
  14. A Sjödin

Corresponding author

Correspondence toJ B Schmidt.

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Competing interests

Dr Schmidt reported receiving a research grant from University of Copenhagen personal grant support from Twinlab and a travel grant from Cambridge Weight Plan UK. Dr Gregersen reported receiving a travel grant from Cambridge Weight Plan UK, and reported being employed by Novo Nordisk A/S (Dr Gregersen was employed at the Department of Nutrition, Exercise and Sports at the time of the study). Dr Pedersen reported receiving travel grants from Cambridge Weight Plan UK and receiving travel expenses and speakers’ honoraria from Novo Nordisk A/S, Eli Lilly and Sanofi Aventis and speakers’ honoraria from Astra Zeneca. M Søndergaard reported receiving a travel grant from Cambridge Weight Plan UK. T Clausen reported being employed by Novo Nordisk A/S, a former employee by Zealand Pharma A/S and holding stocks in Novo Nordisk A/S and Zealand Pharma A/S. Dr Astrup reported receiving research grants from Danish Ministry of Science, Technology and Innovation, and consulting fees from Arena Pharmaceuticals Inc., Basic Research, BioCare Copenhagen, BoehringerIngelheimPharma GmbH & Co.KG, Dutch Beer Knowledge Institute, Gelesis, Gerson Lehrman Group, Global Dairy Platform, Jenny Craig, McCain Foods Limited, McDonald’s, Novo Nordisk, Pathway Genomics Corporation, S-Biotek and Twinlab and personal fees from Vivus. Dr Holst reported that he serves as an advisory board member for Glaxo, Smith, Kline, Novo Nordisk and Zealand Pharmaceuticals and receives grants from NOVARTIS and Merck and consulting fees from Novo Nordisk. The remaining authors declare no conflict of interest.

The Danish Ministry of Science, Technology and Innovation and the Strategic Research Council of the Capital Area had no role in the collection, management, analysis and interpretation of the study data, and had no part in the preparation of the manuscript.

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Schmidt, J., Pedersen, S., Gregersen, N. et al. Effects of RYGB on energy expenditure, appetite and glycaemic control: a randomized controlled clinical trial.Int J Obes 40, 281–290 (2016). https://doi.org/10.1038/ijo.2015.162

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