Serum lipidomics reveals early differential effects of gastric bypass compared with banding on phospholipids and sphingolipids independent of differences in weight loss (original) (raw)

• Sjöström L, Lindroos A-K, Peltonen M, Torgerson J, Bouchard C, Carlsson B et al. Lifestyle, diabetes, and cardiovascular risk factors 10 years after bariatric surgery. N Engl J Med 2004; 351: 2683–2693.
  Article Google Scholar
• Bradley D, Magkos F, Klein S . Effects of bariatric surgery on glucose homeostasis and type 2 diabetes. Gastroenterology 2012; 143: 897–912.
  Article CAS Google Scholar
• Caiazzo R, Lassailly G, Leteurtre E, Baud G, Verkindt H, Raverdy V et al. Roux-en-Y gastric bypass versus adjustable gastric banding to reduce nonalcoholic fatty liver disease: a 5-year controlled longitudinal study. Ann Surg 2014; 260: 893–898.
  Article Google Scholar
• Sjöström L, Peltonen M, Jacobson P, Sjöström CD, Karason K, Wedel H et al. Bariatric surgery and long-term cardiovascular events. JAMA 2012; 307: 56–65.
  Article Google Scholar
• Buchwald H, Estok R, Fahrbach K, Banel D, Jensen MD, Pories WJ et al. Weight and type 2 diabetes after bariatric surgery: systematic review and meta-analysis. Am J Med 2009; 122: e5.
  Article Google Scholar
• Heffron SP, Parikh A, Volodarskiy A, Ren-Fielding C, Schwartzbard A, Nicholson J et al. Changes in lipid profile of obese patients following contemporary bariatric surgery: a meta-analysis. Am J Med 2016; 129: 952–959.
  Article CAS Google Scholar
• Seeley RJ, Chambers AP, Sandoval DA . The role of gut adaptation in the potent effects of multiple bariatric surgeries on obesity and diabetes. Cell Metab 2015; 21: 369–378.
  Article CAS Google Scholar
• Bradley D, Conte C, Mittendorfer B, Eagon JC, Varela JE, Fabbrini E et al. Gastric bypass and banding equally improve insulin sensitivity and β cell function. J Clin Invest 2012; 122: 4667–4674.
  Article CAS Google Scholar
• Jackness C, Karmally W, Febres G, Conwell IM, Ahmed L, Bessler M et al. Very low-calorie diet mimics the early beneficial effect of Roux-en-Y gastric bypass on insulin sensitivity and β-cell Function in type 2 diabetic patients. Diabetes 2013; 62: 3027–3032.
  Article CAS Google Scholar
• Sjöholm K, Sjöström E, Carlsson LMS, Peltonen M . Weight change–adjusted effects of gastric bypass surgery on glucose metabolism: two- and 10-year results from the Swedish Obese Subjects (SOS) Study. Diabetes Care 2016; 39: 625–631.
  Article Google Scholar
• Quehenberger O, Armando AM, Brown AH, Milne SB, Myers DS, Merrill AH et al. Lipidomics reveals a remarkable diversity of lipids in human plasma. J Lipid Res 2010; 51: 3299–3305.
  Article CAS Google Scholar
• Quehenberger O, Dennis EA . The human plasma lipidome. N Engl J Med 2011; 365: 1812–1823.
  Article CAS Google Scholar
• Anjani K, Lhomme M, Sokolovska N, Poitu C, Aron-Winewsky J, Bouillot B et al. Circulating phospholipid profiling identifies portal contribution to NASH signature in obesity. J Hepatology 2015; 62: 905–912.
  Article CAS Google Scholar
• Gorden DL, Myers DS, Ivanova PT, Fahy E, Maurya MR, Gupta S et al. Biomarkers of NAFLD progression: a lipidomics approach to an epidemic. J Lipid Res 2015; 56: 722–736.
  Article CAS Google Scholar
• van der Veen JN, Lingrell S, Vance DE . The membrane lipid phosphatidylcholine is an unexpected source of triacylglycerol in the liver. J Biol Chem 2012; 287: 23418–23426.
  Article CAS Google Scholar
• Camont L, Lhomme M, Rached F, Le Goff W, Nègre-Salvayre A, Salvayre R et al. Small, dense high-density lipoprotein-3 particles are enriched in negatively charged phospholipids relevance to cellular cholesterol efflux, antioxidative, antithrombotic, anti-inflammatory, and antiapoptotic functionalities. Arterioscler Thromb Vasc Biol 2013; 33: 2715–2723.
  Article CAS Google Scholar
• Bikman BT, Summers SA . Ceramides as modulators of cellular and whole-body metabolism. J Clin Invest 2011; 121: 4222–4230.
  Article CAS Google Scholar
• Boon J, Hoy AJ, Stark R, Brown RD, Meex RC, Henstridge DC et al. Ceramides contained in LDL are elevated in type 2 diabetes and promote inflammation and skeletal muscle insulin resistance. Diabetes 2013; 62: 401–410.
  Article CAS Google Scholar
• Ciangura C, Bouillot JL, Lloret-Linares C, Poitou C, Veyrie N, Basdevant A et al. Dynamics of change in total and regional body composition after gastric bypass in obese patients. Obesity (Silver Spring) 2010; 18: 760–765.
  Article Google Scholar
• McAuley KA, Williams SM, Mann JI, Walker RJ, Lewis-Barned NJ, Temple LA et al. Diagnosing insulin resistance in the general population. Diabetes Care 2001; 24: 460–464.
  Article CAS Google Scholar
• Wallace TM, Levy JC, Matthews DR . Use and abuse of HOMA modeling. Diabetes Care 2004; 27: 1487–1495.
  Article Google Scholar
• Palarea-Albaladejo J, Martin-Fernandez JA . Values below detection limit in compositional chemical data. Anal Chim Acta 2013; 764: 32–43.
  Article CAS Google Scholar
• Dunn WB, Broadhurst D, Begley P, Zelena E, Francis-McIntyre S, Anderson N et al. Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry. Nat Protoc 2011; 6: 1060–1083.
  Article CAS Google Scholar
• Sumner LW, Amberg A, Barrett D, Beale MH, Beger R, Daykin CA et al. Proposed minimum reporting standards for chemical analysis Chemical Analysis Working Group (CAWG) Metabolomics Standards Initiative (MSI). Metabolomics 2007; 3: 211–221.
  Article CAS Google Scholar
• Little RA, Rubin DB . Statistical Analysis With Missing Data. John Wiley & Sons: Hoboken, NJ, USA, 2002.
  Book Google Scholar
• Wiesner P, Leidl K, Boettcher A, Schmitz G, Liebisch G . Lipid profiling of FPLC-separated lipoprotein fractions by electrospray ionization tandem mass spectrometry. J Lipid Res 2009; 50: 574–585.
  Article CAS Google Scholar
• Meikle PJ, Wong G, Barlow CK, Weir JM, Greeve MA, MacIntosh GL et al. Plasma lipid profiling shows similar associations with prediabetes and type 2 diabetes. PLoS One 2013; 8: e74341.
  Article CAS Google Scholar
• Graessler J, Bornstein TD, Goel D, Bhalla VP, Lohmann T, Wolf T et al. Lipidomic profiling before and after Roux-en-Y gastric bypass in obese patients with diabetes. Pharmacogenomics J 2014; 14: 201–207.
  Article CAS Google Scholar
• Huang H, Kasumov T, Gatmaitan P, Heneghan HM, Kashyap SR, Schauer PR et al. Gastric bypass surgery reduces plasma ceramide subspecies and improves insulin sensitivity in severely obese patients. Obesity 2011; 19: 2235–2240.
  Article CAS Google Scholar
• Arora T, Velagapudi V, Pournaras DJ, Welbourn R, le Roux CW, Orešič M et al. Roux-en-Y gastric bypass surgery induces early plasma metabolomic and lipidomic alterations in humans associated with diabetes remission. PLoS One 2015; 10: e0126401.
  Article Google Scholar
• Mutch DM, Fuhrmann JC, Rein D, Wiemer JC, Bouillot JL, Poitou C et al. Metabolite profiling identifies candidate markers reflecting the clinical adaptations associated with Roux-en-Y gastric bypass surgery. PLoS One 2009; 4: e7905.
  Article Google Scholar
• Noga AA, Zhao Y, Vance DE . An unexpected requirement for phosphatidylethanolamine N-methyltransferase in the secretion of very low density lipoproteins. J Biol Chem 2002; 277: 42358–42365.
  Article CAS Google Scholar
• Schlitt A, Blankenberg S, Yan D, von Gizycki H, Buerke M, Werdan K et al. Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery disease. Nutr Metab (Lond) 2006; 3: 5.
  Article Google Scholar
• Sigruener A, Kleber ME, Heimerl S, Liebisch G, Schmitz G, Maerz W . Glycerophospholipid and sphingolipid species and mortality: the Ludwigshafen Risk and Cardiovascular Health (LURIC) study. PLoS One 2014; 9: e85724.
  Article Google Scholar
• Meikle PJ, Summers SA . Sphingolipids and phospholipids in insulin resistance and related metabolic disorders. Nat Rev Endocrinol 2016; 13: 79–91.
  Article Google Scholar
• Levy M, Futerman AH . Mammalian ceramide synthases. IUBMB Life 2010; 62: 347–356.
  Article CAS Google Scholar
• Raichur S, Wang ST, Chan PW, Li Y, Ching J, Chaurasia B et al. CerS2 haploinsufficiency inhibits beta-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. Cell Metab 2014; 20: 687–695.
  Article CAS Google Scholar
• Turpin SM, Nicholls HT, Willmes DM, Mourier A, Brodesser S, Wunderlich CM et al. Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance. Cell Metab 2014; 20: 678–686.
  Article CAS Google Scholar
• Gosejacob D, Jäger PS, Vom Dorp K, Frejno M, Carstensen AC, Köhnke M et al. Ceramide synthase 5 is essential to maintain C16:0 ceramide pools and contributes to the development of diet induced obesity. J Biol Chem 2016; 291: 6989–7003.
  Article CAS Google Scholar
• Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH et al. Muscle sphingolipids during rest and exercise: a C18:0 signature for insulin resistance in humans. Diabetologia 2016; 59: 785–798.
  Article CAS Google Scholar
• Laaksonen R, Ekroos K, Sysi-Aho M, Hilvo M, Vihervaara T, Kauhanen D et al. Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol. Eur Heart J 2016; 37: 1967–1976.
  Article CAS Google Scholar
• Merrill AH, Lingrell S, Wang E, Nikolova-Karakashian M, Vales TR, Vance DE . Sphingolipid biosynthesis de novo by rat hepatocytes in culture. Ceramide and sphingomyelin are associated with, but not required for, very low density lipoprotein secretion. J Biol Chem 1995; 270: 13834–13841.
  Article CAS Google Scholar
• Watt MJ, Barnett AC, Bruce CR, Schenk S, Horowitz JF, Hoy AJ . Regulation of plasma ceramide levels with fatty acid oversupply: evidence that the liver detects and secretes de novo synthesised ceramide. Diabetologia 2012; 55: 2741–2746.
  Article CAS Google Scholar
• Bergman BC, Brozinick JT, Strauss A, Bacon S, Kerege A, Bui HH et al. Serum sphingolipids: relationships to insulin sensitivity and changes with exercise in humans. Am J Physiol Endocrinol Metab 2015; 309: E398–E408.
  Article CAS Google Scholar
• Chaston TB, Dixon JB, O’Brien PE . Changes in fat-free mass during significant weight loss: a systematic review. Int J Obes (Lond) 2007; 31: 743–750.
  Article CAS Google Scholar
• Memon RA, Holleran WM, Moser AH, Seki T, Uchida Y, Fuller J et al. Endotoxin and cytokines increase hepatic sphingolipid biosynthesis and produce lipoproteins enriched in ceramides and sphingomyelin. Arterioscler Thromb Vasc Biol 1998; 18: 1257–1265.
  Article CAS Google Scholar
• Chavez JA, Summers SA . Characterizing the effects of saturated fatty acids on insulin signaling and ceramide and diacylglycerol accumulation in 3T3-L1 adipocytes and C2C12 myotubes. Arch Biochem Biophys 2003; 419: 101–109.
  Article CAS Google Scholar
• Jiang C, Xie C, Li F, Zhang L, Nichols RG, Krausz KW et al. Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease. J Clin Invest 2015; 125: 386–402.
  Article Google Scholar
• Aron-Wisnewsky J, Verger EO, Bounaix C, Dao MC, Oppert JM, Bouillot JL et al. Nutritional and protein deficiencies in the short term following both gastric bypass and gastric banding. PLoS One 2016; 11: e0149588.
  Article Google Scholar