Developmentally induced Mll1 loss reveals defects in postnatal haematopoiesis (original) (raw)

• Behm FG, Raimondi SC, Frestedt JL, Liu Q, Crist WM, Downing JR et al. Rearrangement of the MLL gene confers a poor prognosis in childhood acute lymphoblastic leukemia, regardless of presenting age. Blood 1996; 87: 2870–2877.
  CAS PubMed Google Scholar
• Liedtke M, Cleary ML . Therapeutic targeting of MLL. Blood 2009; 113: 6061–6068.
  Article CAS PubMed PubMed Central Google Scholar
• Milne TA, Briggs SD, Brock HW, Martin ME, Gibbs D, Allis CD et al. MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell 2002; 10: 1107–1117.
  Article CAS PubMed Google Scholar
• Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R et al. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell 2002; 10: 1119–1128.
  Article CAS PubMed Google Scholar
• Zeleznik-Le NJ, Harden AM, Rowley JD . 11q23 translocations split the ‘AT-hook’ cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene. Proc Natl Acad Sci USA 1994; 91: 10610–10614.
  Article CAS PubMed PubMed Central Google Scholar
• Slany RK, Lavau C, Cleary ML . The oncogenic capacity of HRX-ENL requires the transcriptional transactivation activity of ENL and the DNA binding motifs of HRX. Mol Cell Biol 1998; 18: 122–129.
  Article CAS PubMed PubMed Central Google Scholar
• Ayton PM, Chen EH, Cleary ML . Binding to nonmethylated CpG DNA is essential for target recognition, transactivation, and myeloid transformation by an MLL oncoprotein. Mol Cell Biol 2004; 24: 10470–10478.
  Article CAS PubMed PubMed Central Google Scholar
• Yokoyama A, Cleary ML . Menin critically links MLL proteins with LEDGF on cancer-associated target genes. Cancer Cell 2008; 14: 36–46.
  Article CAS PubMed PubMed Central Google Scholar
• Bach C, Mueller D, Buhl S, Garcia-Cuellar MP, Slany RK . Alterations of the CxxC domain preclude oncogenic activation of mixed-lineage leukemia 2. Oncogene 2009; 28: 815–823.
  Article CAS PubMed Google Scholar
• Daser A, Rabbitts TH . Extending the repertoire of the mixed-lineage leukemia gene MLL in leukemogenesis. Genes Dev 2004; 18: 965–974.
  Article CAS PubMed Google Scholar
• Yu BD, Hess JL, Horning SE, Brown GA, Korsmeyer SJ . Altered Hox expression and segmental identity in Mll-mutant mice. Nature 1995; 378: 505–508.
  Article CAS PubMed Google Scholar
• Ayton P, Sneddon SF, Palmer DB, Rosewell IR, Owen MJ, Young B et al. Truncation of the Mll gene in exon 5 by gene targeting leads to early preimplantation lethality of homozygous embryos. Genesis 2001; 30: 201–212.
  Article CAS PubMed Google Scholar
• Ernst P, Fisher JK, Avery W, Wade S, Foy D, Korsmeyer SJ . Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell 2004; 6: 437–443.
  Article CAS PubMed Google Scholar
• Terranova R, Agherbi H, Boned A, Meresse S, Djabali M . Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci USA 2006; 103: 6629–6634.
  Article CAS PubMed PubMed Central Google Scholar
• McMahon KA, Hiew SY, Hadjur S, Veiga-Fernandes H, Menzel U, Price AJ et al. Mll has a critical role in fetal and adult hematopoietic stem cell self-renewal. Cell Stem Cell 2007; 1: 338–345.
  Article CAS PubMed Google Scholar
• Jude CD, Climer L, Xu D, Artinger E, Fisher JK, Ernst P . Unique and independent roles for MLL in adult hematopoietic stem cells and progenitors. Cell Stem Cell 2007; 1: 324–337.
  Article CAS PubMed PubMed Central Google Scholar
• Yano T, Nakamura T, Blechman J, Sorio C, Dang CV, Geiger B et al. Nuclear punctate distribution of ALL-1 is conferred by distinct elements at the N terminus of the protein. Proc Natl Acad Sci USA 1997; 94: 7286–7291.
  Article CAS PubMed PubMed Central Google Scholar
• Kuhn R, Schwenk F, Aguet M, Rajewsky K . Inducible gene targeting in mice. Science 1995; 269: 1427–1429.
  Article CAS PubMed Google Scholar
• Jude CD, Gaudet JJ, Speck NA, Ernst P . Leukemia and hematopoietic stem cells: balancing proliferation and quiescence. Cell Cycle 2008; 7: 586–591.
  Article CAS PubMed Google Scholar
• Baron ML, Gauchat D, La Motte-Mohs R, Kettaf N, Abdallah A, Michiels T et al. TLR ligand-induced type I IFNs affect thymopoiesis. J Immunol 2008; 180: 7134–7146.
  Article CAS PubMed Google Scholar
• Demoulins T, Abdallah A, Kettaf N, Baron ML, Gerarduzzi C, Gauchat D et al. Reversible blockade of thymic output: an inherent part of TLR ligand-mediated immune response. J Immunol 2008; 181: 6757–6769.
  Article CAS PubMed Google Scholar
• Despres D, Goldschmitt J, Aulitzky WE, Huber C, Peschel C . Differential effect of type I interferons on hematopoietic progenitor cells: failure of interferons to inhibit IL-3-stimulated normal and CML myeloid progenitors. Exp Hematol 1995; 23: 1431–1438.
  CAS PubMed Google Scholar
• Mizutani T, Tsuji K, Ebihara Y, Taki S, Ohba Y, Taniguchi T et al. Homeostatic erythropoiesis by the transcription factor IRF2 through attenuation of type I interferon signaling. Exp Hematol 2008; 36: 255–264.
  Article CAS PubMed Google Scholar
• Essers MA, Offner S, Blanco-Bose WE, Waibler Z, Kalinke U, Duchosal MA et al. IFNalpha activates dormant haematopoietic stem cells in vivo. Nature 2009; 458: 904–908.
  Article CAS PubMed Google Scholar
• Sato T, Onai N, Yoshihara H, Arai F, Suda T, Ohteki T . Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med 2009; 15: 696–700.
  Article CAS PubMed Google Scholar
• Ogilvy S, Metcalf D, Gibson L, Bath ML, Harris AW, Adams JM . Promoter elements of vav drive transgene expression in vivo throughout the hematopoietic compartment. Blood 1999; 94: 1855–1863.
  CAS PubMed Google Scholar
• de Boer J, Williams A, Skavdis G, Harker N, Coles M, Tolaini M et al. Transgenic mice with hematopoietic and lymphoid specific expression of Cre. Eur J Immunol 2003; 33: 314–325.
  Article CAS PubMed Google Scholar
• Georgiades P, Ogilvy S, Duval H, Licence DR, Charnock-Jones DS, Smith SK et al. VavCre transgenic mice: a tool for mutagenesis in hematopoietic and endothelial lineages. Genesis 2002; 34: 251–256.
  Article CAS PubMed Google Scholar
• Stadtfeld M, Graf T . Assessing the role of hematopoietic plasticity for endothelial and hepatocyte development by non-invasive lineage tracing. Development 2005; 132: 203–213.
  Article CAS PubMed Google Scholar
• Yagi H, Deguchi K, Aono A, Tani Y, Kishimoto T, Komori T . Growth disturbance in fetal liver hematopoiesis of Mll-mutant mice. Blood 1998; 92: 108–117.
  CAS PubMed Google Scholar
• Kim I, He S, Yilmaz OH, Kiel MJ, Morrison SJ . Enhanced purification of fetal liver hematopoietic stem cells using SLAM family receptors. Blood 2006; 108: 737–744.
  Article CAS PubMed PubMed Central Google Scholar
• Bhandoola A, Sambandam A . From stem cell to T cell: one route or many? Nat Rev Immunol 2006; 6: 117–126.
  Article CAS PubMed Google Scholar
• Chen MJ, Yokomizo T, Zeigler BM, Dzierzak E, Speck NA . Runx1 is required for the endothelial to haematopoietic cell transition but not thereafter. Nature 2009; 457: 887–891.
  Article CAS PubMed PubMed Central Google Scholar
• Abshire TC, Buchanan GR, Jackson JF, Shuster JJ, Brock B, Head D et al. Morphologic, immunologic and cytogenetic studies in children with acute lymphoblastic leukemia at diagnosis and relapse: a Pediatric Oncology Group study. Leukemia 1992; 6: 357–362.
  CAS PubMed Google Scholar
• Huret JL, Brizard A, Slater R, Charrin C, Bertheas MF, Guilhot F et al. Cytogenetic heterogeneity in t(11;19) acute leukemia: clinical, hematological and cytogenetic analyses of 48 patients--updated published cases and 16 new observations. Leukemia 1993; 7: 152–160.
  CAS PubMed Google Scholar
• Pui CH, Chessells JM, Camitta B, Baruchel A, Biondi A, Boyett JM et al. Clinical heterogeneity in childhood acute lymphoblastic leukemia with 11q23 rearrangements. Leukemia 2003; 17: 700–706.
  Article CAS PubMed Google Scholar