Mutations of the BRAF gene in human cancer (original) (raw)

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Acknowledgements

We would like to thank all the patients who donated samples for these studies, the UK Children's Cancer Study Group for provision of paediatric primary tumour samples, the NCCGP for provision of cord blood control DNA samples, and W. Haynes for assistance with preparation of the manuscript. We would also like to acknowledge the Wellcome Trust, Institute of Cancer Research and Cancer Research UK for support. C.J.M. is a Gibb life fellow of the Cancer Research UK. G.P. and A.C. are funded in part by Regione Autonoma della Sardegna. B.A.G. is supported by Breakthrough Breast Cancer.

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Author notes

1. Helen Davies, Graham R. Bignell, Charles Cox and Philip Stephens: These authors contributed equally to this work

Authors and Affiliations

1. Cancer Genome Project, The Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, CB10 1SA
   Helen Davies, Graham R. Bignell, Charles Cox, Philip Stephens, Sarah Edkins, Sheila Clegg, Jon Teague, Hayley Woffendin, William Bottomley, Neil Davis, Ed Dicks, Rebecca Ewing, Yvonne Floyd, Kristian Gray, Sarah Hall, Rachel Hawes, Jaime Hughes, Vivian Kosmidou, Andrew Menzies, Catherine Mould, Adrian Parker, Claire Stevens, Stephen Watt, Richard Wooster, Michael R. Stratton & P. Andrew Futreal
2. Cancer Research UK Centre for Cell and Molecular Biology, Chester Beatty Labs, Institute of Cancer Research, London, SW3 6JB, UK
   Mathew J. Garnett, Steven Hooper, Rebecca Wilson, Hugh Paterson, Richard Marais & Christopher J. Marshall
3. Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK
   Hiran Jayatilake & Michael R. Stratton
4. Section of Molecular Carcinogenesis, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK
   Colin Cooper, Janet Shipley & Richard Wooster
5. Section of Paediatrics, Institute of Cancer Research, Sutton, Surrey, SM2 5NG, UK
   Darren Hargrave & Katherine Pritchard-Jones
6. Department of Pathology, Western Infirmary, University of Glasgow, S11 6NT, UK
   Barry A. Gusterson
7. Department of Biology, YCR Cancer Research Unit, University of York, York, YO10 5YW, UK
   Norman Maitland
8. Queensland Institute of Medical Research, RBH Post Office Herston, Queensland, 4029, Australia
   Georgia Chenevix-Trench
9. Department of Pathology, Duke University Medical Centre, Durham, North Carolina, 27710, USA
   Gregory J. Riggins & Darell D. Bigner
10. Department of Surgery, Duke University Medical Centre, Durham, North Carolina, 27710, USA
    Adrienne Flanagan, Hilliard F. Seigler & Timothy L. Darrow
11. Institute of Molecular Genetics, C.N.R, Loc. Tramariglio, Alghero, 07040, Italy
    Giuseppe Palmieri
12. Department of Pathology, University of Sassari, Azienda USL1, Sassari, 07100, Italy
    Antonio Cossu
13. Royal Free & University College Medical School, London, WC1E 6JJ, UK
    Adrienne Flanagan
14. Royal Brompton Hospital, London, SW3 6NP, UK
    Andrew Nicholson
15. Department of Surgery, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Judy W. C. Ho
16. Department of Pathology, The University of Hong Kong, Queen Mary Hospital, Hong Kong
    Suet Y. Leung & Siu T. Yuen
17. Abramson Family Cancer Research Institute, University of Pennsylvania Cancer Center, Philadelphia, Pennsylvania, 19104, USA
    Barbara L. Weber

Authors

1. Helen Davies
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2. Graham R. Bignell
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3. Charles Cox
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4. Philip Stephens
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5. Sarah Edkins
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6. Sheila Clegg
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7. Jon Teague
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8. Hayley Woffendin
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9. Mathew J. Garnett
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10. William Bottomley
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11. Neil Davis
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19. Vivian Kosmidou
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20. Andrew Menzies
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24. Stephen Watt
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25. Steven Hooper
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26. Rebecca Wilson
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27. Hiran Jayatilake
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28. Barry A. Gusterson
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29. Colin Cooper
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30. Janet Shipley
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31. Darren Hargrave
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32. Katherine Pritchard-Jones
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33. Norman Maitland
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34. Georgia Chenevix-Trench
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35. Gregory J. Riggins
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36. Darell D. Bigner
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37. Giuseppe Palmieri
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38. Antonio Cossu
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39. Adrienne Flanagan
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40. Andrew Nicholson
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41. Judy W. C. Ho
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42. Suet Y. Leung
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43. Siu T. Yuen
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44. Barbara L. Weber
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45. Hilliard F. Seigler
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46. Timothy L. Darrow
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47. Hugh Paterson
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48. Richard Marais
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49. Christopher J. Marshall
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50. Richard Wooster
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51. Michael R. Stratton
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52. P. Andrew Futreal
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Corresponding author

Correspondence toRichard Wooster.

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The authors declare that they have no competing financial interests.

Supplementary information

41586_2002_BFnature00766_MOESM1_ESM.xls

Supplementary Table 1: Primer sequences used to amplify BRAF, HRAS, KRAS and NRAS; BRAF mutations; BRAF polymorphisms; RAS mutations; Full list of cell lines screened (XLS 69 kb)

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Davies, H., Bignell, G., Cox, C. et al. Mutations of the BRAF gene in human cancer.Nature 417, 949–954 (2002). https://doi.org/10.1038/nature00766

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• Received: 02 February 2002
• Accepted: 16 May 2002
• Published: 09 June 2002
• Issue Date: 27 June 2002
• DOI: https://doi.org/10.1038/nature00766