The Rad50 zinc-hook is a structure joining Mre11 complexes in DNA recombination and repair (original) (raw)

• Haber, J. E. The many interfaces of Mre11. Cell 95, 583–586 (1998)
  Article CAS Google Scholar
• Bressan, D. A., Baxter, B. K. & Petrini, J. H. The Mre11–Rad50–Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae. Mol. Cell. Biol. 19, 7681–7687 (1999)
  Article CAS Google Scholar
• Moreau, S., Ferguson, J. R. & Symington, L. S. The nuclease activity of Mre11 is required for meiosis but not for mating type switching, end joining, or telomere maintenance. Mol. Cell. Biol. 19, 556–566 (1999)
  Article CAS Google Scholar
• Yamaguchi-Iwai, Y. et al. Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells. EMBO J. 18, 6619–6629 (1999)
  Article CAS Google Scholar
• Tsukamoto, Y., Taggart, A. K. & Zakian, V. A. The role of the Mre11–Rad50–Xrs2 complex in telomerase-mediated lengthening of Saccharomyces cerevisiae telomeres. Curr. Biol. 11, 1328–1335 (2001)
  Article CAS Google Scholar
• Merino, S. T., Cummings, W. J., Acharya, S. N. & Zolan, M. E. Replication-dependent early meiotic requirement for Spo11 and Rad50. Proc. Natl Acad. Sci. USA 97, 10477–10482 (2000)
  Article ADS CAS Google Scholar
• Hartsuiker, E., Vaessen, E., Carr, A. M. & Kohli, J. Fission yeast Rad50 stimulates sister chromatid recombination and links cohesion with repair. EMBO J. 20, 6660–6671 (2001)
  Article CAS Google Scholar
• Hopfner, K. P. et al. Structural biochemistry and interaction architecture of the DNA double-strand break repair Mre11 nuclease and Rad50-ATPase. Cell 105, 473–485 (2001)
  Article CAS Google Scholar
• Petrini, J. H. The Mre11 complex and ATM: collaborating to navigate S phase. Curr. Opin. Cell Biol. 12, 293–296 (2000)
  Article CAS Google Scholar
• Huang, J. & Dynan, W. S. Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction. Nucleic Acids Res. 30, 667–674 (2002)
  Article CAS Google Scholar
• Furuse, M. et al. Distinct roles of two separable in vitro activities of yeast Mre11 in mitotic and meiotic recombination. Embo J 17, 6412–6425 (1998)
  Article CAS Google Scholar
• Paull, T. T. & Gellert, M. The 3′ to 5′ exonuclease activity of Mre 11 facilitates repair of DNA double-strand breaks. Mol. Cell 1, 969–979 (1998)
  Article CAS Google Scholar
• Connelly, J. C., de Leau, E. S. & Leach, D. R. DNA cleavage and degradation by the SbcCD protein complex from Escherichia coli. Nucleic Acids Res. 27, 1039–1046 (1999)
  Article CAS Google Scholar
• Hopfner, K. P. et al. Mre11 and Rad50 from Pyrococcus furiosus: cloning and biochemical characterization reveal an evolutionarily conserved multiprotein machine. J. Bacteriol. 182, 6036–6041 (2000)
  Article CAS Google Scholar
• Trujillo, K. M. & Sung, P. DNA structure-specific nuclease activities in the Saccharomyces cerevisiae Rad50/Mre11 complex. J. Biol. Chem. 276, 35458–35464 (2001)
  Article CAS Google Scholar
• Lobachev, K. S., Gordenin, D. A. & Resnick, M. A. The Mre11 complex is required for repair of hairpin-capped double-strand breaks and prevention of chromosome rearrangements. Cell 108, 183–193 (2002)
  Article CAS Google Scholar
• Xiao, Y. & Weaver, D. T. Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells. Nucleic Acids Res. 25, 2985–2991 (1997)
  Article CAS Google Scholar
• Luo, G. et al. Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation. Proc. Natl Acad. Sci. USA 96, 7376–7381 (1999)
  Article ADS CAS Google Scholar
• Zhu, J., Petersen, S., Tessarollo, L. & Nussenzweig, A. Targeted disruption of the Nijmegen breakage syndrome gene NBS1 leads to early embryonic lethality in mice. Curr. Biol. 11, 105–109 (2001)
  Article CAS Google Scholar
• de Jager, M. et al. Human Rad50/Mre11 is a flexible complex that can tether DNA ends. Mol. Cell 8, 1129–1135 (2001)
  Article CAS Google Scholar
• Chen, L., Trujillo, K., Ramos, W., Sung, P. & Tomkinson, A. E. Promotion of Dnl4-catalyzed DNA end-joining by the Rad50/Mre11/Xrs2 and Hdf1/Hdf2 complexes. Mol. Cell 8, 1105–1115 (2001)
  Article CAS Google Scholar
• Hopfner, K. P. et al. Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily. Cell 101, 789–800 (2000)
  Article CAS Google Scholar
• Connelly, J. C., Kirkham, L. A. & Leach, D. R. The SbcCD nuclease of Escherichia coli is a structural maintenance of chromosomes (SMC) family protein that cleaves hairpin DNA. Proc. Natl Acad. Sci. USA 95, 7969–7974 (1998)
  Article ADS CAS Google Scholar
• Anderson, D. E., Trujillo, K. M., Sung, P. & Erickson, H. P. Structure of the Rad50 × Mre11 DNA repair complex from Saccharomyces cerevisiae by electron microscopy. J. Biol. Chem. 276, 37027–37033 (2001)
  Article CAS Google Scholar
• Sharples, G. J. & Leach, D. R. Structural and functional similarities between the SbcCD proteins of Escherichia coli and the RAD50 and MRE11 (RAD32) recombination and repair proteins of yeast. Mol. Microbiol. 17, 1215–1217 (1995)
  Article CAS Google Scholar
• Hirano, T. SMC-mediated chromosome mechanics: a conserved scheme from bacteria to vertebrates? Genes Dev. 13, 11–19 (1999)
  Article CAS Google Scholar
• Wu, X. & McMurray, C. T. Calmodulin kinase II attenuation of gene transcription by preventing cAMP response element-binding protein (CREB) dimerization and binding of the CREB-binding protein. J. Biol. Chem. 276, 1735–1741 (2001)
  Article CAS Google Scholar
• Brunger, A. T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905–921 (1998)
  Article CAS Google Scholar
• Bressan, D. A., Olivares, H. A., Nelms, B. E. & Petrini, J. H. Alteration of N-terminal phosphoesterase signature motifs inactivates Saccharomyces cerevisiae Mre11. Genetics 150, 591–600 (1998)
  CAS PubMed PubMed Central Google Scholar
• Usui, T., Ogawa, H. & Petrini, J. H. A DNA damage response pathway controlled by Tel1 and the Mre11 complex. Mol. Cell 7, 1255–1266 (2001)
  Article CAS Google Scholar