HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites (original) (raw)

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Acknowledgements

We thank M. Dybul for providing primary isolates pi102, pi104, pi202 and pi204; M. A. Gawinowisc for matrix-assisted laser desorption/ionization–time of flight analysis; Z. Moodie and A. Palmer for help with error analysis; A. Fauci, S. Harrison, A. Miranker, R. Seder and L. Shapiro for discussions; and D. Dimitrov, B. Kwong, N. Letvin, J. Mascola, G. Nabel and Q. Sattentau for comments. This work was supported by grants from the National Institutes of Health and by a Center for AIDS Research grant to the Dana-Farber Cancer Institute. The Dana-Farber Cancer Institute is also the recipient of a Cancer Center Grant from the National Institutes of Health. Columbia University is a participant in a Center for AIDS Research. R.W. was a fellow of the American Foundation for AIDS Research and P.D.K. was a recipient of a Burroughs Wellcome Career Development award.

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Author notes

1. Michael L. Doyle & Wayne A. Hendrickson
   Present address: Biopharmaceuticals Department H13-07, Bristol-Myers Squibb PRI, Pharmaceutical Research Institute, P.O. Box 4000, Princeton, New Jersey, 08543-4000, USA

Authors and Affiliations

1. Vaccine Research Center, National Institutes of Health, Bethesda, Maryland, 20892, USA
   Peter D. Kwong, Shahzad Majeed, Miro Venturi & Richard Wyatt
2. National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, 20892, USA
   Claudia Cicala, Tavis D. Steenbeke & James Arthos
3. Department of Biochemistry and Molecular Biophysics, Columbia University, New York, New York, 10032, USA
   Peter D. Kwong, Shahzad Majeed & Wayne A. Hendrickson
4. Howard Hughes Medical Institute, Columbia University, USA, New York, 10032, New York
   Wayne A. Hendrickson
5. Department of Structural Biology, GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania, 19406, USA
   Michael L. Doyle & David J. Casper
6. Department of Biology, Johns Hopkins University, Baltimore, Maryland, 21218, USA
   Stephanie A. Leavitt & Ernesto Freire
7. Department of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, 19104, USA
   Irwin Chaiken & Donald Van Ryk
8. Cell Biology, Tanox, Houston, Texas, 77025, USA
   Michael Fung
9. Institute for Applied Microbiology, University of Agriculture and Forestry, A-1190, Vienna, Austria
   Hermann Katinger
10. Departments of Immunology and Molecular Biology, Scripps Research Institute, La Jolla, California, 92037, USA
    Paul W. I. H. Parren & Dennis R. Burton
11. Department of Pediatrics, Tulane University Medical Center, New Orleans, Louisiana, 70112, USA
    James Robinson
12. Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, and Department of Pathology, Division of AIDS, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Liping Wang, Richard Wyatt & Joseph Sodroski
13. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, 02115, USA
    Joseph Sodroski

Authors

1. Peter D. Kwong
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2. Michael L. Doyle
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3. David J. Casper
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4. Claudia Cicala
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5. Stephanie A. Leavitt
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6. Shahzad Majeed
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7. Tavis D. Steenbeke
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8. Miro Venturi
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9. Irwin Chaiken
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10. Michael Fung
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11. Hermann Katinger
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12. Paul W. I. H. Parren
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13. James Robinson
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14. Donald Van Ryk
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15. Liping Wang
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16. Dennis R. Burton
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17. Ernesto Freire
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18. Richard Wyatt
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19. Joseph Sodroski
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20. Wayne A. Hendrickson
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21. James Arthos
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Correspondence toPeter D. Kwong.

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Kwong, P., Doyle, M., Casper, D. et al. HIV-1 evades antibody-mediated neutralization through conformational masking of receptor-binding sites.Nature 420, 678–682 (2002). https://doi.org/10.1038/nature01188

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• Received: 28 May 2002
• Accepted: 23 September 2002
• Issue Date: 12 December 2002
• DOI: https://doi.org/10.1038/nature01188