- Munger, J. S. et al. The integrin αvβ6 binds and activates latent TGFβ1: a mechanism for regulating pulmonary inflammation and fibrosis. Cell 96, 319–328 (1999)
Article CAS Google Scholar
- Pittet, J. F. et al. TGF-β is a critical mediator of acute lung injury. J. Clin. Invest. 107, 1537–1544 (2001)
Article CAS Google Scholar
- Kaminski, N. et al. Global analysis of gene expression in pulmonary fibrosis reveals distinct programs regulating lung inflammation and fibrosis. Proc. Natl Acad. Sci. USA 97, 1778–1783 (2000)
Article ADS CAS Google Scholar
- Werb, Z. & Gordon, S. Elastase secretion by stimulated macrophages. Characterization and regulation. J. Exp. Med. 142, 361–377 (1975)
Article CAS Google Scholar
- Shapiro, S. D. et al. Molecular cloning, chromosomal localization, and bacterial expression of a murine macrophage metalloelastase. J. Biol. Chem. 267, 4664–4671 (1992)
CAS PubMed Google Scholar
- Belaaouaj, A. et al. Human macrophage metalloelastase. Genomic organization, chromosomal location, gene linkage, and tissue-specific expression. J. Biol. Chem. 270, 14568–14575 (1995)
Article CAS Google Scholar
- Hautamaki, R. D., Kobayashi, D. K., Senior, R. M. & Shapiro, S. D. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277, 2002–2004 (1997)
Article CAS Google Scholar
- Agrez, M., Chen, A., Cone, R. I., Pytela, R. & Sheppard, D. The αvβ6 integrin promotes proliferation of colon carcinoma cells through a unique region of the beta 6 cytoplasmic domain. J. Cell Biol. 127, 547–556 (1994)
Article CAS Google Scholar
- Huang, X. Z., Chen, A., Agrez, M. & Sheppard, D. A point mutation in the integrin β6 subunit abolishes both αvβ6 binding to fibronectin and receptor localization to focal contacts. Am. J. Respir. Cell. Mol. Biol. 13, 245–251 (1995)
Article CAS Google Scholar
- Huang, X., Wu, J., Zhu, W., Pytela, R. & Sheppard, D. Expression of the human integrin β6 subunit in alveolar type II cells and bronchiolar epithelial cells reverses lung inflammation in β6 knockout mice. Am. J. Respir. Cell. Mol. Biol. 19, 636–642 (1998)
Article CAS Google Scholar
- Feinberg, M. W. et al. Transforming growth factor-β 1 inhibits cytokine-mediated induction of human metalloelastase in macrophages. J. Biol. Chem. 275, 25766–25773 (2000)
Article CAS Google Scholar
- Werner, F. et al. Transforming growth factor-β 1 inhibition of macrophage activation is mediated via Smad3. J. Biol. Chem. 275, 36653–36658 (2000)
Article CAS Google Scholar
- Huang, X. Z. et al. Inactivation of the integrin β6 subunit gene reveals a role of epithelial integrins in regulating inflammation in the lung and skin. J. Cell Biol. 133, 921–928 (1996)
Article CAS Google Scholar
- Wang, Z. et al. Interferon gamma induction of pulmonary emphysema in the adult murine lung. J. Exp. Med. 192, 1587–1600 (2000)
Article CAS Google Scholar
- Fujita, M. et al. Overexpression of tumour necrosis factor-α produces an increase in lung volumes and pulmonary hypertension. Am. J. Physiol. Lung Cell Mol. Physiol. 280, L39–L49 (2001)
Article CAS Google Scholar
- Zheng, T. et al. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. J. Clin. Invest. 106, 1081–1093 (2000)
Article CAS Google Scholar
- Wert, S. E. et al. Increased metalloproteinase activity, oxidant production, and emphysema in surfactant protein D gene-inactivated mice. Proc. Natl Acad. Sci. USA 97, 5972–5977 (2000)
Article ADS CAS Google Scholar
- Leco, K. J. et al. Spontaneous air space enlargement in the lungs of mice lacking tissue inhibitor of metalloproteinases-3 (TIMP-3). J. Clin. Invest. 108, 817–829 (2001)
Article CAS Google Scholar
- Kasahara, Y. et al. Inhibition of VEGF receptors causes lung cell apoptosis and emphysema. J. Clin. Invest. 106, 1311–1319 (2000)
Article CAS Google Scholar
- Niewoehner, D. E., Kleinerman, J. & Rice, D. B. Pathologic changes in the peripheral airways of young cigarette smokers. N. Engl. J. Med. 291, 755–758 (1974)
Article CAS Google Scholar
- Silverman, E. K. et al. Genetic epidemiology of severe, early-onset chronic obstructive pulmonary disease. Risk to relatives for airflow obstruction and chronic bronchitis. Am. J. Respir. Crit. Care Med. 157, 1770–1778 (1998)
Article CAS Google Scholar
- Wikenheiser, K. A., Clark, J. C., Linnoila, R. I., Stahlman, M. T. & Whitsett, J. A. Simian virus 40 large T antigen directed by transcriptional elements of the human surfactant protein C gene produces pulmonary adenocarcinomas in transgenic mice. Cancer Res. 52, 5342–5352 (1992)
CAS PubMed Google Scholar
- Cone, R. I., Weinacker, A., Chen, A. & Sheppard, D. Effects of beta subunit cytoplasmic domain deletions on the recruitment of the integrin αvβ6 to focal contacts. Cell Adhes. Commun. 2, 101–113 (1994)
Article CAS Google Scholar
- Clark, J. C. et al. FGF-10 disrupts lung morphogenesis and causes pulmonary adenomas in vivo. Am. J. Physiol. Lung. Cell. Mol. Physiol. 280, L705–L715 (2001)
Article ADS CAS Google Scholar
- Liu, X. et al. Conditional epidermal expression of TGF beta 1 blocks neonatal lethality but causes a reversible hyperplasia and alopecia. Proc. Natl Acad. Sci. USA 98, 9139–9144 (2001)
Article ADS CAS Google Scholar
- Dolganov, G. M. et al. A novel method of gene transcript profiling in airway biopsy homogenates reveals increased expression of a Na+-K+-Cl- cotransporter (NKCC1) in asthmatic subjects. Genome Res. 11, 1473–1483 (2001)
Article CAS Google Scholar
- Dunnill, M. S. Quantitative methods in the study of pulmonary pathology. Thorax 17, 320–328 (1962)
Article CAS Google Scholar