Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-α (original) (raw)

References

  1. Rodríguez de Fonseca, F. et al. An anorexic lipid mediator regulated by feeding. Nature 414, 209–212 (2001)
    Article ADS Google Scholar
  2. Gaetani, S., Oveisi, F. & Piomelli, D. Modulation of meal pattern in the rat by the anorexic lipid mediator oleoylethanolamide. Neuropsychopharmacology 28, 1311–1316 (2003)
    Article CAS Google Scholar
  3. Göttlicher, M., Widmark, E., Li, Q. & Gustafsson, J. A. Fatty acids activate a chimera of the clofibric acid-activated receptor and the glucocorticoid receptor. Proc. Natl Acad. Sci. USA 89, 4653–4657 (1992)
    Article ADS Google Scholar
  4. Kliewer, S. A. et al. Fatty acids and eicosanoids regulate gene expression through direct interactions with peroxisome proliferator-activated receptors α and γ. Proc. Natl Acad. Sci. USA 94, 4318–4323 (1997)
    Article ADS CAS Google Scholar
  5. Forman, B. M., Chen, J. & Evans, R. M. Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors α and δ. Proc. Natl Acad. Sci. USA 94, 4312–4317 (1997)
    Article ADS CAS Google Scholar
  6. Desvergne, B. & Wahli, W. Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr. Rev. 20, 649–688 (1999)
    CAS PubMed Google Scholar
  7. Chawla, A., Repa, J. J., Evans, R. M. & Mangelsdorf, D. J. Nuclear receptors and lipid physiology: opening the X-files. Science 294, 1866–1870 (2001)
    Article ADS CAS Google Scholar
  8. Berger, J. & Moller, D. E. The mechanisms of action of PPARs. Annu. Rev. Med. 53, 409–435 (2002)
    Article CAS Google Scholar
  9. Lazennec, G., Canaple, L., Saugy, D. & Wahli, W. Activation of peroxisome proliferator-activated receptors (PPARs) by their ligands and protein kinase A activators. Mol. Endocrinol. 14, 1962–1975 (2000)
    Article CAS Google Scholar
  10. Devane, W. A. et al. Isolation and structure of a brain constituent that binds to the cannabinoid receptor. Science 258, 1946–1949 (1992)
    Article ADS CAS Google Scholar
  11. Willson, T. M., Brown, P. J., Sternbach, D. D. & Henke, B. R. The PPARs: from orphan receptors to drug discovery. J. Med. Chem. 43, 527–550 (2000)
    Article CAS Google Scholar
  12. Brown, P. J. et al. Chemical compounds as selective activators of PPAR-α. PCT Int. Appl. 32 (2000)
  13. Lee, S. S. et al. Targeted disruption of the α isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators. Mol. Cell. Biol. 15, 3012–3022 (1995)
    Article CAS Google Scholar
  14. Butler, A. A. & Cone, R. D. Knockout models resulting in the development of obesity. Trends Genet. 17, S50–S54 (2001)
    Article CAS Google Scholar
  15. Oliver, W. R. Jr et al. A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport. Proc. Natl Acad. Sci. USA 98, 5306–5311 (2001)
    Article ADS CAS Google Scholar
  16. Chang, A. Y., Wyse, B. M., Gilchrist, B. J., Peterson, T. & Diani, A. R. Ciglitazone, a new hypoglycemic agent. I. Studies in ob/ob and db/db mice, diabetic Chinese hamsters, and normal and streptozotocin-diabetic rats. Diabetes 32, 830–838 (1983)
    Article CAS Google Scholar
  17. Martin, G., Schoonjans, K., Lefebvre, A. M., Staels, B. & Auwerx, J. Coordinate regulation of the expression of the fatty acid transport protein and acyl-CoA synthetase genes by PPARα and PPARγ activators. J. Biol. Chem. 272, 28210–28217 (1997)
    Article CAS Google Scholar
  18. Escher, P. et al. Rat PPARs: quantitative analysis in adult rat tissues and regulation in fasting and refeeding. Endocrinology 142, 4195–4202 (2001)
    Article CAS Google Scholar
  19. Motojima, K., Passilly, P., Peters, J. M., González, F. J. & Latruffe, N. Expression of putative fatty acid transporter genes are regulated by peroxisome proliferator-activated receptor α and γ activators in a tissue- and inducer-specific manner. J. Biol. Chem. 273, 16710–16714 (1998)
    Article CAS Google Scholar
  20. Colville-Nash, P. R., Qureshi, S. S. & Willoughby, D. A. Inhibition of inducible nitric oxide synthase by peroxisome proliferator-activated receptor agonist: correlation of induction of heme oxygenase 1. J. Immunol. 161, 978–984 (1998)
    CAS PubMed Google Scholar
  21. Best, J. D. & Jenkins, A. J. Novel agents for managing dyslipidaemia. Expert Opin. Invest. Drugs 10, 1901–1911 (2001)
    Article CAS Google Scholar
  22. Cleary, M. P., Kasiske, B., O'Donnell, M. P. & Keane, W. F. Effect of long-term clofibric acid treatment on serum and tissue lipid and cholesterol levels in obese Zucker rats. Atherosclerosis 66, 107–112 (1987)
    Article CAS Google Scholar
  23. Chaput, E., Saladin, R., Silvestre, M. & Edgar, A. D. Fenofibrate and rosiglitazone lower serum triglycerides with opposing effects on body weight. Biochem. Biophys. Res. Commun. 271, 445–450 (2000)
    Article CAS Google Scholar
  24. Akiyama, T. E. et al. Peroxisome proliferator-activated receptor-α regulates lipid homeostasis, but is not associated with obesity: studies with congenic mouse lines. J. Biol. Chem. 276, 39088–39093 (2001)
    Article CAS Google Scholar
  25. Sticker-krongrad, A., Beck, B. & Burlet, C. Nitric oxide mediates hyperphagia of obese Zucker rats: relation to specific changes in the microstructure of feeding behavior. Life Sci. 58, PL9–PL15 (1996)
    Google Scholar
  26. Janero, D. R. Nutritional aspects of nitric oxide: human health implication and therapeutic opportunities. Nutrition 17, 896–903 (2001)
    Article CAS Google Scholar
  27. Chao, E. Y.-H. et al. Thiazoles and oxazole derivatives and their pharmaceutical use. PCT Int. Appl. 83 (2001).
  28. Giuffrida, A., Rodríguez de Fonseca, F. & Piomelli, D. Quantification of bioactive acylethanolamides in rat plasma by electrospray mass spectrometry. Anal. Biochem. 280, 87–93 (2000)
    Article CAS Google Scholar
  29. Schmittgen, T. D. et al. Quantitative reverse transcription-polymerase chain reaction to study mRNA decay: comparison of endpoint and real-time methods. Anal. Biochem. 285, 194–204 (2000)
    Article CAS Google Scholar
  30. Gregoire, F. M. et al. Diet-induced obesity and hepatic gene expression alterations in C57BL/6J and ICAM-1-deficient mice. Am. J. Physiol. Endocrinol. Metab. 282, E703–E713 (2002)
    Article CAS Google Scholar

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