Genome-wide phenotype analysis in ES cells by regulated disruption of Bloom's syndrome gene (original) (raw)

• German, J. Bloom's syndrome. Dermatol. Clin. 13, 7–18 (1995)
  Article CAS Google Scholar
• Groden, J., Nakamura, Y. & German, J. Molecular evidence that homologous recombination occurs in proliferating human somatic cells. Proc. Natl Acad. Sci. USA 87, 4315–4319 (1990)
  Article ADS CAS Google Scholar
• Luo, G. et al. Cancer predisposition caused by elevated mitotic recombination in Bloom mice. Nature Genet. 26, 424–429 (2000)
  Article CAS Google Scholar
• Kyba, M. & Daley, G. Q. Hematopoiesis from embryonic stem cells: lessons from and for ontogeny. Exp. Hematol. 31, 994–1006 (2003)
  Article CAS Google Scholar
• Kim, J. H. et al. Dopamine neurons derived from embryonic stem cells function in an animal model of Parkinson's disease. Nature 418, 50–56 (2002)
  Article ADS CAS Google Scholar
• Parisi, S. et al. Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells. J. Cell Biol. 163, 303–314 (2003)
  Article CAS Google Scholar
• Reubinoff, B. E., Pera, M. F., Fong, C. Y., Trounson, A. & Bongso, A. Embryonic stem cell lines from human blastocysts: somatic differentiation in vitro. Nature Biotechnol. 18, 399–404 (2000)
  Article CAS Google Scholar
• Thomson, J. A. et al. Embryonic stem cell lines derived from human blastocysts. Science 282, 1145–1147 (1998)
  Article ADS CAS Google Scholar
• Bond, C. T. et al. Respiration and parturition affected by conditional overexpression of the Ca2+-activated K+ channel subunit, SK3. Science 289, 1942–1946 (2000)
  Article ADS CAS Google Scholar
• Sonoda, E. et al. Sister chromatid exchanges are mediated by homologous recombination in vertebrate cells. Mol. Cell. Biol. 19, 5166–5169 (1999)
  Article CAS Google Scholar
• Koike, H. et al. Efficient biallelic mutagenesis with Cre/_loxP_-mediated inter-chromosomal recombination. EMBO Rep. 3, 433–437 (2002)
  Article CAS Google Scholar
• Luria, S. E. & Delbruck, M. Mutation of bacteria from virus sensitivity to virus resistance. Genetics 28, 491–510 (1943)
  CAS PubMed PubMed Central Google Scholar
• Lefebvre, L., Dionne, N., Karaskova, J., Squire, J. A. & Nagy, A. Selection for transgene homozygosity in embryonic stem cells results in extensive loss of heterozygosity. Nature Genet. 27, 257–258 (2001)
  Article CAS Google Scholar
• Chen, Y. et al. Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells. Nature Genet. 24, 314–317 (2000)
  Article CAS Google Scholar
• Hong, Y. et al. Requirement of _N_-glycan on GPI-anchored proteins for efficient binding of aerolysin but not Clostridium septicum α-toxin. EMBO J. 21, 5047–5056 (2002)
  Article CAS Google Scholar
• Kawagoe, K., Takeda, J., Endo, Y. & Kinoshita, T. Molecular cloning of murine pig-a, a gene for GPI-anchor biosynthesis, and demonstration of interspecies conservation of its structure, function, and genetic locus. Genomics 23, 566–574 (1994)
  Article CAS Google Scholar
• Kondoh, G. et al. Tissue-inherent fate of GPI revealed by GPI-anchored GFP transgenesis. FEBS Lett. 458, 299–303 (1999)
  Article CAS Google Scholar
• Liu, P., Jenkins, N. A. & Copeland, N. G. Efficient Cre–_loxP_-induced mitotic recombination in mouse embryonic stem cells. Nature Genet. 30, 66–72 (2002)
  Article CAS Google Scholar
• Gupta, R. S., Chan, D. Y. & Siminovitch, L. Evidence for functional hemizygosity at the Emtr locus in CHO cells through segregation analysis. Cell 14, 1007–1013 (1978)
  Article CAS Google Scholar
• Hanada, K. et al. Molecular machinery for non-vesicular trafficking of ceramide. Nature 426, 803–809 (2003)
  Article ADS CAS Google Scholar
• Nakamura, N. et al. Expression cloning of PIG-L, a candidate _N_-acetylglucosaminyl-phosphatidylinositol deacetylase. J. Biol. Chem. 272, 15834–15840 (1997)
  Article CAS Google Scholar
• Munroe, R. J. et al. Mouse mutants from chemically mutagenized embryonic stem cells. Nature Genet. 24, 318–321 (2000)
  Article CAS Google Scholar
• Chambers, I. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell 113, 643–655 (2003)
  Article CAS Google Scholar
• Kitamura, T. et al. Retrovirus-mediated gene transfer and expression cloning: powerful tools in functional genomics. Exp. Hematol. 31, 1007–1014 (2003)
  Article MathSciNet CAS Google Scholar
• Eggan, K. et al. Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation. Proc. Natl Acad. Sci. USA 98, 6209–6214 (2001)
  Article ADS CAS Google Scholar
• Friedrich, G. & Soriano, P. Promoter traps in embryonic stem cells: a genetic screen to identify and mutate developmental genes in mice. Genes Dev. 5, 1513–1523 (1991)
  Article CAS Google Scholar
• Guo, G., Wang, W. & Bradley, A. Mismatch repair genes identified using genetic screens in Blm-deficient embryonic stem cells. Nature (this issue)