A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity (original) (raw)

• Wakeland, E., Liu, K., Graham, R. & Behrens, T. Delineating the genetic basis of systemic lupus erythematosus. Immunity 15, 397–408 (2001)
  Article CAS Google Scholar
• Mills, D. M. & Cambier, J. C. B lymphocyte activation during cognate interactions with CD4 + T lymphocytes: molecular dynamics and immunologic consequences. Semin. Immunol. 15, 325–329 (2003)
  Article CAS Google Scholar
• Tafuri, A. et al. ICOS is essential for effective T-helper-cell responses. Nature 409, 105–109 (2001)
  Article ADS CAS Google Scholar
• McAdam, A. J. et al. ICOS is critical for CD40-mediated antibody class switching. Nature 409, 102–105 (2001)
  Article ADS CAS Google Scholar
• Dong, C. et al. ICOS co-stimulatory receptor is essential for T-cell activation and function. Nature 409, 97–101 (2001)
  Article ADS CAS Google Scholar
• Dong, C., Temann, U. A. & Flavell, R. A. Cutting edge: critical role of inducible costimulator in germinal center reactions. J. Immunol. 166, 3659–3662 (2001)
  Article CAS Google Scholar
• Mak, T. W. et al. Costimulation through the inducible costimulator ligand is essential for both T helper and B cell functions in T cell-dependent B cell responses. Nature Immunol. 4, 765–772 (2003)
  Article CAS Google Scholar
• Wong, S. C., Oh, E., Ng, C. H. & Lam, K. P. Impaired germinal center formation and recall T-cell-dependent immune responses in mice lacking the costimulatory ligand B7–H2. Blood 102, 1381–1388 (2003)
  Article CAS Google Scholar
• Parrish-Novak, J. et al. Interleukin 21 and its receptor are involved in NK cell expansion and regulation of lymphocyte function. Nature 408, 57–63 (2000)
  Article ADS CAS Google Scholar
• Ozaki, K. et al. A critical role for IL-21 in regulating immunoglobulin production. Science 298, 1630–1634 (2002)
  Article ADS CAS Google Scholar
• MacLennan, I. C. Germinal centers. Annu. Rev. Immunol. 12, 117–139 (1994)
  Article CAS Google Scholar
• Walker, L. S., Gulbranson-Judge, A., Flynn, S., Brocker, T. & Lane, P. J. Co-stimulation and selection for T-cell help for germinal centres: the role of CD28 and OX40. Immunol. Today 21, 333–337 (2000)
  Article CAS Google Scholar
• Hutloff, A. et al. ICOS is an inducible T-cell co-stimulator structurally and functionally related to CD28. Nature 397, 263–266 (1999)
  Article ADS CAS Google Scholar
• Lohning, M. et al. Expression of ICOS in vivo defines CD4 + effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J. Exp. Med. 197, 181–193 (2003)
  Article CAS Google Scholar
• Moser, B., Schaerli, P. & Loetscher, P. CXCR5+ T cells: follicular homing takes center stage in T-helper-cell responses. Trends Immunol. 23, 250–254 (2002)
  Article CAS Google Scholar
• Chtanova, T. et al. T follicular helper cells express a distinctive transcriptional profile, reflecting their role as non-Th1/Th2 effector cells that provide help for B cells. J. Immunol. 173, 68–78 (2004)
  Article CAS Google Scholar
• Kim, C. H. et al. Unique gene expression program of human germinal center T helper cells. Blood 104, 1952–1960 (2004)
  Article CAS Google Scholar
• Grimbacher, B. et al. Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. Nature Immunol. 4, 261–268 (2003)
  Article CAS Google Scholar
• Toellner, K. M. et al. T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching. J. Exp. Med. 187, 1193–1204 (1998)
  Article CAS Google Scholar
• Jun, J. et al. Identifying the MAGUK protein Carma-1 as a central regulator of humoral immune responses and atopy by genome-wide mouse mutagenesis. Immunity 18, 751–762 (2003)
  Article CAS Google Scholar
• Akkaraju, S. et al. A range of CD4 T cell tolerance: partial inactivation to organ-specific antigen allows nondestructive thyroiditis or insulitis. Immunity 7, 255–271 (1997)
  Article CAS Google Scholar
• Lesage, S. et al. Failure to censor forbidden clones of CD4 T cells in autoimmune diabetes. J. Exp. Med. 196, 1175–1188 (2002)
  Article CAS Google Scholar
• Liston, A., Lesage, S., Wilson, J., Peltonen, L. & Goodnow, C. Aire regulates negative selection of organ-specific T cells. Nature Immunol. 4, 350–354 (2003)
  Article CAS Google Scholar
• Bouillet, P. et al. BH3-only Bcl-2 family member Bim is required for apoptosis of autoreactive thymocytes. Nature 415, 922–926 (2002)
  Article ADS CAS Google Scholar
• Scherer, M. T., Ignatowicz, L., Pullen, A., Kappler, J. & Marrack, P. The use of mammary tumor virus (Mtv)-negative and single-Mtv mice to evaluate the effects of endogenous viral superantigens on the T cell repertoire. J. Exp. Med. 182, 1493–1504 (1995)
  Article CAS Google Scholar
• Chiang, Y. et al. Cbl-b regulates the CD28 dependence of T-cell activation. Nature 403, 216–220 (2000)
  Article ADS CAS Google Scholar
• Jeon, M. S. et al. Essential role of the E3 ubiquitin ligase Cbl-b in T cell anergy induction. Immunity 21, 167–177 (2004)
  Article CAS Google Scholar
• Peng, S. L., Gerth, A. J., Ranger, A. M. & Glimcher, L. NFATc1 and NFATc2 together control both T and B cell activation and differentiation. Immunity 14, 13–20 (2001)
  Article CAS Google Scholar
• Khattri, R., Cox, T., Yasayko, S. A. & Ramsdell, F. An essential role for Scurfin in CD4 + CD25 + T regulatory cells. Nature Immunol. 4, 337–342 (2003)
  Article CAS Google Scholar
• Fontenot, J. D., Gavin, M. A. & Rudensky, A. Y. Foxp3 programs the development and function of CD4 + CD25 + regulatory T cells. Nature Immunol. 4, 330–336 (2003)
  Article CAS Google Scholar
• Ozaki, K. et al. Regulation of B cell differentiation and plasma cell generation by IL-21, a novel inducer of Blimp-1 and Bcl-6. J. Immunol. 173, 5361–5371 (2004)
  Article CAS Google Scholar
• Yoshinaga, S. K. et al. T-cell co-stimulation through B7RP-1 and ICOS. Nature 402, 827–832 (1999)
  Article ADS CAS Google Scholar
• Blackshear, P. J. Tristetraprolin and other CCCH tandem zinc-finger proteins in the regulation of mRNA turnover. Biochem. Soc. Trans. 30, 945–952 (2002)
  Article CAS Google Scholar
• Barabino, S. M., Ohnacker, M. & Keller, W. Distinct roles of two Yth1p domains in 3′-end cleavage and polyadenylation of yeast pre-mRNAs. EMBO J. 19, 3778–3787 (2000)
  Article CAS Google Scholar
• Hudson, B., Martinez-Yamout, M., Dyson, H. & Wright, P. Recognition of the mRNA AU-rich element by the zinc finger domain of TIS11d. Nature Struct. Mol. Biol. 11, 257–264 (2004)
  Article CAS Google Scholar
• Morking, P. A. et al. TcZFP1: a CCCH zinc finger protein of Trypanosoma cruzi that binds poly-C oligoribonucleotides in vitro. Biochem. Biophys. Res. Commun. 319, 169–177 (2004)
  Article Google Scholar
• Anderson, P. & Kedersha, N. Stressful initiations. J. Cell Sci. 115, 3227–3234 (2002)
  CAS PubMed Google Scholar
• Iwai, H. et al. Involvement of inducible costimulator-B7 homologous protein costimulatory pathway in murine lupus nephritis. J. Immunol. 171, 2848–2854 (2003)
  Article CAS Google Scholar
• Hutloff, A. et al. Involvement of inducible costimulator in the exaggerated memory B cell and plasma cell generation in systemic lupus erythematosus. Arthritis Rheum. 50, 3211–3220 (2004)
  Article Google Scholar
• Greve, B. et al. The diabetes susceptibility locus Idd5.1 on mouse chromosome 1 regulates ICOS expression and modulates murine experimental autoimmune encephalomyelitis. J. Immunol. 173, 157–163 (2004)
  Article CAS Google Scholar
• King, C., Ilic, A., Koelsch, K. & Sarvetnick, N. Homeostatic expansion of T cells during immune insufficiency generates autoimmunity. Cell 117, 265–277 (2004)
  Article CAS Google Scholar
• Kearney, E. R., Pape, K. A., Loh, D. Y. & Jenkins, M. K. Visualization of peptide-specific T cell immunity and peripheral tolerance induction in vivo. Immunity 1, 327–339 (1994)
  Article CAS Google Scholar
• Fillatreau, S. & Gray, D. T cell accumulation in B cell follicles is regulated by dendritic cells and is independent of B cell activation. J. Exp. Med. 197, 195–206 (2003)
  Article CAS Google Scholar
• Brocker, T. et al. CD4 T cell traffic control: in vivo evidence that ligation of OX40 on CD4 T cells by OX40-ligand expressed on dendritic cells leads to the accumulation of CD4 T cells in B follicles. Eur. J. Immunol. 29, 1610–1616 (1999)
  Article CAS Google Scholar
• Zheng, N., Wang, P., Jeffrey, P. D. & Pavletich, N. P. Structure of a c-Cbl-UbcH7 complex: RING domain function in ubiquitin-protein ligases. Cell 102, 533–539 (2000)
  Article CAS Google Scholar
• Zheng, N. et al. Structure of the Cul1-Rbx1-Skp1-F boxSkp2 SCF ubiquitin ligase complex. Nature 416, 703–709 (2002)
  Article ADS CAS Google Scholar
• Wickens, M. & Goldstrohm, A. A place to die, a place to sleep. Science 300, 753–755 (2003)
  Article CAS Google Scholar
• Crotty, S., Kersh, E. N., Cannons, J., Schwartzberg, P. L. & Ahmed, R. SAP is required for generating long-term humoral immunity. Nature 421, 282–287 (2003)
  Article ADS CAS Google Scholar
• Okamoto, S. et al. Expression of the SH2D1A gene is regulated by a combination of transcriptional and post-transcriptional mechanisms. Eur. J. Immunol. 34, 3176–3186 (2004)
  Article CAS Google Scholar
• Laroia, G., Cuesta, R., Brewer, G. & Schneider, R. J. Control of mRNA decay by heat shock–ubiquitin–proteasome pathway. Science 284, 499–502 (1999)
  Article ADS CAS Google Scholar