Crystal structure of a bacterial homologue of Na+/Cl--dependent neurotransmitter transporters (original) (raw)
References
Vanhatalo, S. & Soinila, S. The concept of chemical neurotransmission — variations on the theme. Ann. Med.19, 151–158 (1998) Article Google Scholar
Masson, J., Sagne, C., Hamon, M. & Mestikawy, S. E. Neurotransmitter transporters in the central nervous system. Pharm. Rev.51, 439–464 (1999) CASPubMed Google Scholar
Hahn, M. K. & Blakely, R. D. Monoamine transporter gene structure and polymorphisms in relation to psychiatric and other complex disorders. Pharmacogenomics J.2, 217–235 (2002) ArticleCAS Google Scholar
Richerson, G. B. & Wu, Y. Role of the GABA transporter in epilepsy. Adv. Exp. Med. Biol.548, 76–91 (2004) ArticleCAS Google Scholar
Amara, S. G. & Sonders, M. S. Neurotransmitter transporters as molecular targets for addictive drugs. Drug Alcohol Depend.51, 87–96 (1998) ArticleCAS Google Scholar
Krogsgaard-Larsen, P., Frolund, B. & Frydenvang, K. GABA uptake inhibitors. Design, molecular pharmacology and therapeutic aspects. Curr. Pharm. Des.6, 1193–1209 (2000) ArticleCAS Google Scholar
Barker, E. L. & Blakely, R. D. in Psychopharmacology—the Fourth Generation of Progress (eds Bloom, F. E. & Kupfer, D. J.) (Raven Press, New York, 2000) Google Scholar
Guastella, J. et al. Cloning and expression of a rat brain GABA transporter. Science249, 1303–1306 (1990) ArticleADSCAS Google Scholar
Nelson, N. The family of Na+/Cl--dependent neurotransmitter transporters. J. Neurochem.71, 1785–1803 (1998) ArticleCAS Google Scholar
Torres, G. E., Gainetdinov, R. R. & Caron, M. G. Plasma membrane monoamine transporters: structure, regulation, and function. Nature Rev. Neurosci.4, 13–25 (2003) ArticleCAS Google Scholar
Chen, J. G., Liu-Chen, S. & Rudnick, G. Determination of external loop topology in the serotonin transporter by site-directed chemical labeling. J. Biol. Chem.273, 12675–12681 (1998) ArticleCAS Google Scholar
Bismuth, Y., Kavanaugh, M. P. & Kanner, B. I. Tyrosine 140 of the γ-aminobutyric acid transporter GAT-1 plays a critical role in neurotransmitter recognition. J. Biol. Chem.272, 16096–16102 (1997) ArticleCAS Google Scholar
Chen, J. G., Sachpatzidis, A. & Rudnick, G. The third transmembrane domain of the serotonin transporter contains residues associated with substrate and cocaine binding. J. Biol. Chem.272, 28321–28327 (1997) ArticleCAS Google Scholar
Cao, Y., Li, M., Mager, S. & Lester, H. A. Amino acid residues that control pH modulation of transport-associated current in mammalian serotonin transporters. J. Neurosci.18, 7739–7749 (1998) ArticleCAS Google Scholar
Rudnick, G. in Neurotransmitter Transporters: Structure, Function, and Regulation (ed. Reith, E. A.) 25–52 (Humana Press, Totowa, New Jersey, 2002) Book Google Scholar
Kavanaugh, M. P., Arriza, J. L., North, R. A. & Amara, S. G. Electrogenic uptake of γ-aminobutyric acid by a cloned transporter expressed in Xenopus oocytes. J. Biol. Chem.267, 22007–22009 (1992) CASPubMed Google Scholar
Roux, M. & Supplisson, S. Neuronal and glial glycine transporters have different stoichiometries. Neuron25, 373–383 (2000) ArticleCAS Google Scholar
Androutsellis-Theotokis, A. et al. Characterization of a functional bacterial homologue of sodium-dependent neurotransmitter transporters. J. Biol. Chem.278, 12703–12709 (2003) ArticleCAS Google Scholar
Hendrickson, W. A. Determination of macromolecular structures from anomalous diffraction of synchrotron radiation. Science254, 51–58 (1991) ArticleADSCAS Google Scholar
Murata, K. et al. Structural determinants of water permeation through aquaporin-1. Nature407, 599–605 (2000) ArticleADSCAS Google Scholar
Hirai, T. et al. Three-dimensional structure of a bacterial oxalate transporter. Nature Struct. Biol.9, 597–600 (2002) CASPubMed Google Scholar
Chen, J. G., Liu-Chen, S. & Rudnick, G. External cysteine residues in the serotonin transporter. Biochemistry36, 1479–1486 (1997) ArticleCAS Google Scholar
Wang, J. B., Moriwaki, A. & Uhl, G. R. Dopamine transporter cysteine mutants: second extracellular loop cysteines are required for transporter expression. J. Neurochem.64, 1416–1419 (1995) ArticleCAS Google Scholar
Just, H., Sitte, H. H., Schmid, J. A., Freissmuth, M. & Kudlacek, O. Identification of an additional interaction domain in transmembrane domains 11 and 12 that supports oligomer formation in the human serotonin transporter. J. Biol. Chem.279, 6650–6657 (2004) ArticleCAS Google Scholar
Sitte, H. H., Farhan, H. & Javitch, J. A. Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking. Mol. Interv.4, 38–47 (2004) ArticleCAS Google Scholar
Ponce, J., Biton, B., Benavides, J., Avenet, P. & Aragon, C. Transmembrane domain III plays an important role in ion binding and permeation in the glycine transporter GLYT2. J. Biol. Chem.275, 13856–13862 (2000) ArticleCAS Google Scholar
Keshet, G. I. et al. Glutamate-101 is critical for the function of the sodium and chloride-coupled GABA transporter GAT-1. FEBS Lett.371, 39–42 (1995) ArticleCAS Google Scholar
Nayal, M. & Di Cera, E. Valence screening of water in protein crystals reveals potential Na+ binding sites. J. Mol. Biol.256, 228–234 (1996) ArticleCAS Google Scholar
Harding, M. M. Metal-ligand geometry relevant to proteins and in proteins: sodium and potassium. Acta Crystallogr. D58, 872–874 (2002) Article Google Scholar
Mager, S. et al. Ion binding and permeation at the GABA transporter GAT1. J. Neurosci.16, 5405–5414 (1996) ArticleCAS Google Scholar
Penado, K. M., Rudnick, G. & Stephan, M. M. Critical amino acid residues in transmembrane span 7 of the serotonin transporter identified by random mutagenesis. J. Biol. Chem.273, 28098–28106 (1998) ArticleCAS Google Scholar
Chen, N. & Reith, M. E. Na+ and the substrate permeation pathway in dopamine transporters. Eur. J. Pharmacol.479, 213–221 (2003) ArticleCAS Google Scholar
Mari, S. A. et al. Aspartate 338 contributes to the cationic specificity and to driver-amino acid coupling in the insect cotransporter KAAT1. Cell. Mol. Life Sci.61, 243–256 (2004) ArticleCAS Google Scholar
Jardetzky, O. Simple allosteric model for membrane pumps. Nature211, 969–970 (1966) ArticleADSCAS Google Scholar
Pantanowitz, S., Bendahan, A. & Kanner, B. I. Only one of the charged amino acids located in the transmembrane alpha-helices of the γ-aminobutyric acid transporter (subtype A) is essential for its activity. J. Biol. Chem.268, 3222–3225 (1993) CASPubMed Google Scholar
Bennett, E. R., Su, H. & Kanner, B. I. Mutation of arginine 44 of GAT-1, a (Na+ + Cl-)-coupled γ-aminobutyric acid transporter from rat brain, impairs net flux but not exchange. J. Biol. Chem.275, 34106–34113 (2000) ArticleCAS Google Scholar
Loland, C. J., Granas, C., Javitch, J. A. & Gether, U. Identification of intracellular residues in the dopamine transporter critical for regulation of transporter conformation and cocaine binding. J. Biol. Chem.279, 3228–3238 (2004) ArticleCAS Google Scholar
Loland, C. J., Norregaard, L., Litman, T. & Gether, U. Generation of an activating Zn2+ switch in the dopamine transporter: mutation of an intracellular tyrosine constitutively alters the conformational equilibrium of the transport cycle. Proc. Natl Acad. Sci. USA99, 1683–1688 (2002) ArticleADSCAS Google Scholar
Toyoshima, C. & Nomura, H. Structural changes in the calcium pump accompanying the dissociation of calcium. Nature418, 605–611 (2002) ArticleADSCAS Google Scholar
Lopez-Corcuera, B., Nunez, E., Martinez-Maza, R., Geerlings, A. & Aragon, C. Substrate-induced conformational changes of extracellular loop 1 in the glycine transporter GLYT2. J. Biol. Chem.276, 43463–43470 (2001) ArticleCAS Google Scholar
Sato, Y., Zhang, Y. W., Androutsellis-Theotokis, A. & Rudnick, G. Analysis of transmembrane domain 2 of rat serotonin transporter by cysteine scanning mutagenesis. J. Biol. Chem.279, 22926–22933 (2004) ArticleCAS Google Scholar
Stephan, M. M., Chen, M. A., Penado, K. M. & Rudnick, G. An extracellular loop region of the serotonin transporter may be involved in the translocation mechanism. Biochemistry36, 1322–1328 (1997) ArticleCAS Google Scholar
Smicun, Y., Campbell, S. D., Chen, M. A., Gu, H. & Rudnick, G. The role of external loop regions in serotonin transport. J. Biol. Chem.274, 36058–36064 (1999) ArticleCAS Google Scholar
Yernool, D., Boudker, O., Jin, Y. & Gouaux, E. Structure of a glutamate transporter homologue from Pyrococcus horikoshii. Nature431, 811–818 (2004) ArticleADSCAS Google Scholar
Guerrero, S. A., Hecht, H. J., Hofmann, B., Biebl, H. & Singh, M. Production of selenomethionine-labelled proteins using simplified culture conditions and generally applicable host/vector systems. Appl. Microbiol. Biotechnol.56, 718–723 (2001) ArticleCAS Google Scholar
Terwilliger, T. C. & Berendzen, J. Automated MAD and MIR structure solution. Acta Crystallogr. D55, 849–861 (1999) ArticleCAS Google Scholar
Collaborative Computational Project, No. 4, The CCP4 suite: program for protein crystallography. Acta Crystallogr. D50, 760–763 (1994) Article Google Scholar
Perrakis, A., Morris, R. & Lamzin, V. S. Automated protein model building combined with iterative structure refinement. Nature Struct. Biol.6, 458–463 (1999) ArticleCAS Google Scholar
Brünger, A. T. et al. Crystallography & NMR system: a new software suite for maclomolecular structure determination. Acta Crystallogr. D54, 905–921 (1998) Article Google Scholar
Yernool, D., Boudker, O., Folta-Stogniew, E. & Gouaux, E. Trimeric subunit stoichiometry of the glutamate transporters from Bacillus caldotenax and Bacillus stearothermophilus. Biochemistry42, 12981–12988 (2003) ArticleCAS Google Scholar