A SUMOylation-dependent pathway mediates transrepression of inflammatory response genes by PPAR-γ (original) (raw)

• Lehmann, J. M. et al. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ). J. Biol. Chem. 270, 12953–12956 (1995)
  Article CAS Google Scholar
• Spiegelman, B. M. PPARγ: adipogenic regulator and thiazolidinedione receptor. Diabetes 47, 507–514 (1998)
  Article CAS Google Scholar
• Willson, T. M., Lambert, M. H. & Kliewer, S. A. Peroxisome proliferator-activated receptor γ and metabolic disease. Annu. Rev. Biochem. 70, 341–367 (2001)
  Article CAS Google Scholar
• Haffner, S. M. et al. Effect of rosiglitazone treatment on nontraditional markers of cardiovascular disease in patients with type 2 diabetes mellitus. Circulation 106, 679–684 (2002)
  Article CAS Google Scholar
• Li, A. et al. Peroxisome proliferator-activated receptor γ ligands inhibit development of atherosclerosis in LDL receptor-deficient mice. J. CIin. Invest. 106, 523–531 (2000)
  Article CAS Google Scholar
• Chen, J. D. & Evans, R. M. A transcriptional co-repressor that interacts with nuclear hormone receptors. Nature 377, 454–457 (1995)
  Article ADS CAS Google Scholar
• Horlein, A. J. et al. Ligand-independent repression by the thyroid hormone receptor mediated by a nuclear receptor co-repressor. Nature 377, 397–404 (1995)
  Article ADS CAS Google Scholar
• Glass, C. K. & Rosenfeld, M. G. The coregulator exchange in transcriptional functions of nuclear receptors. Genes Dev. 14, 121–141 (2000)
  CAS Google Scholar
• Guenther, M., Lane, W., Fischle, W., Verdin, E. & Lazar, M. A Core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness. Genes Dev. 14, 1048–1057 (2000)
  CAS PubMed PubMed Central Google Scholar
• Li, J. et al. Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3. EMBO J. 19, 4342–4350 (2000)
  Article CAS Google Scholar
• Zhang, J., Kalkum, M., Chait, B. T. & Roeder, R. G. The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2. Mol. Cell 9, 611–623 (2002)
  Article CAS Google Scholar
• Yoon, H. G. et al. Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1. EMBO J. 22, 1336–1346 (2003)
  Article CAS Google Scholar
• Perissi, V., Aggarwal, A., Glass, C. K., Rose, D. W. & Rosenfeld, M. G. A corepressor/coactivator exchange complex required for transcriptional activation by nuclear receptors and other regulated transcription factors. Cell 116, 511–526 (2004)
  Article CAS Google Scholar
• Ogawa, S. et al. A nuclear receptor corepressor transcriptional checkpoint controlling activator protein 1-dependent gene networks required for macrophage activation. Proc. Natl Acad. Sci. USA 101, 14461–14466 (2004)
  Article ADS CAS Google Scholar
• Hoberg, J. E., Yeung, F. & Mayo, M. W. SMRT derepression by the IκB kinase α: A prerequisite to NF-κB transcription and survival. Mol. Cell 16, 245–255 (2004)
  Article CAS Google Scholar
• Lowenstein, C. J. et al. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon γ and lipopolysaccharide. Proc. Natl Acad. Sci. USA 90, 9730–9734 (1993)
  Article ADS CAS Google Scholar
• Ricote, M., Li, A. C., Willson, T. M., Kelly, C. J. & Glass, C. K. The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation. Nature 391, 79–82 (1998)
  Article ADS CAS Google Scholar
• Oberfield, J. L. et al. A peroxisome proliferator-activated receptor γ ligand inhibits adipocyte differentiation. Proc. Natl Acad. Sci. USA 96, 6102–6106 (1999)
  Article ADS CAS Google Scholar
• Tontonoz, P., Nagy, L., Alvarez, J. G. A., Thomazy, V. A. & Evans, R. M. PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell 93, 241–252 (1998)
  Article CAS Google Scholar
• Li, M., Pascual, G. & Glass, C. Peroxisome proliferator-activated receptor γ-dependent repression of the inducible nitric oxide synthase gene. Mol. Cell. Biol. 20, 4699–4707 (2000)
  Article CAS Google Scholar
• Liu, B. et al. Inhibition of Stat1-mediated gene activation by PIAS1. Proc. Natl Acad. Sci. USA 95, 10626–10631 (1998)
  Article ADS CAS Google Scholar
• Jackson, P. K. A new RING for SUMO: wrestling transcriptional responses into nuclear bodies with PIAS family E3 SUMO ligases. Genes Dev. 15, 3053–3058 (2001)
  Article CAS Google Scholar
• Tallec, L. P. et al. Protein inhibitor of activated signal transducer and activator of transcription 1 interacts with the N-terminal domain of mineralocorticoid receptor and represses its transcriptional activity: implication of small ubiquitin-related modifier 1 modification. Mol. Endocrinol. 17, 2529–2542 (2003)
  Article Google Scholar
• Janne, O. A. et al. Androgen-receptor-interacting nuclear proteins. Biochem. Soc. Trans. 28, 401–405 (2000)
  Article CAS Google Scholar
• Tan, J. et al. Protein inhibitor of activated STAT-1 (signal transducer and activator of transcription-1) is a nuclear receptor coregulator expressed in human testis. Mol. Endocrinol. 14, 14–26 (2000)
  Article CAS Google Scholar
• Kotaja, N., Karvonen, U., Janne, O. A. & Palvimo, J. J. PIAS proteins modulate transcription factors by functioning as SUMO-1 ligases. Mol. Cell. Biol. 22, 5222–5234 (2002)
  Article CAS Google Scholar
• Ling, Y. et al. Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription. Nucleic Acids Res. 32, 598–610 (2004)
  Article CAS Google Scholar
• Nishida, T. & Yasuda, H. PIAS1 and PIASxα function as SUMO-E3 ligases toward androgen receptor and repress androgen receptor-dependent transcription. J. Biol. Chem. 277, 41311–41317 (2002)
  Article CAS Google Scholar
• Ohshima, T., Koga, H. & Shimotohno, K. Transcriptional activity of peroxisome proliferator-activated receptor γ Is modulated by SUMO-1 modification. J. Biol. Chem. 279, 29551–29557 (2004)
  Article CAS Google Scholar
• Muller, S., Hoege, C., Pyrowolakis, G. & Jentsch, S. SUMO, ubiquitin's mysterious cousin. Nature Rev. Mol. Cell Biol. 2, 202–210 (2001)
  Article CAS Google Scholar