Calcium triggers exit from meiosis II by targeting the APC/C inhibitor XErp1 for degradation (original) (raw)

References

  1. Tunquist, B. J. & Maller, J. L. Under arrest: cytostatic factor (CSF)-mediated metaphase arrest in vertebrate eggs. Genes Dev. 17, 683–710 (2003)
    Article CAS Google Scholar
  2. Masui, Y. & Markert, C. L. Cytoplasmic control of nuclear behaviour during meiotic maturation of frog oocytes. J. Exp. Zool. 177, 129–145 (1971)
    Article CAS Google Scholar
  3. King, R. W. et al. A 20S complex containing CDC27 and CDC15 catalyzes the mitosis-specific conjugation of ubiquitin to cyclin B. Cell 81, 279–288 (1995)
    Article CAS Google Scholar
  4. Sudakin, V. et al. The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol. Biol. Cell 6, 185–197 (1995)
    Article CAS Google Scholar
  5. Salah, S. M. & Nasmyth, K. Destruction of the securin Pds1p occurs at the onset of anaphase during both meiotic divisions in yeast. Chromosoma 109, 27–34 (2000)
    Article CAS Google Scholar
  6. Busa, W. B. & Nuccitelli, R. An elevated free cytosolic Ca2+ wave follows fertilization in eggs of the frog, Xenopus laevis. J. Cell Biol. 100, 1325–1329 (1985)
    Article CAS Google Scholar
  7. Lorca, T. et al. Degradation of the proto-oncogene product p39mos is not necessary for cyclin proteolysis and exit from meiotic metaphase: requirement for a Ca(2 + )-calmodulin dependent event. EMBO J. 10, 2087–2093 (1991)
    Article CAS Google Scholar
  8. Lorca, T. et al. Calmodulin-dependent protein kinase II mediates inactivation of MPF and CSF upon fertilization of Xenopus eggs. Nature 366, 270–273 (1993)
    Article ADS CAS Google Scholar
  9. Schmidt, A. et al. Xenopus polo-like kinase Plx1 regulates XErp1, a novel inhibitor of APC/C activity. Genes Dev. 19, 502–513 (2005)
    Article CAS Google Scholar
  10. Fuchs, S. Y., Spiegelman, V. S. & Kumar, K. G. The many faces of beta-TrCP E3 ubiquitin ligases: reflections in the magic mirror of cancer. Oncogene 23, 2028–2036 (2004)
    Article CAS Google Scholar
  11. Descombes, P. & Nigg, E. A. The polo-like kinase Plx1 is required for M phase exit and destruction of mitotic regulators in Xenopus egg extracts. EMBO J. 17, 1328–1335 (1998)
    Article CAS Google Scholar
  12. Elia, A. E., Cantley, L. C. & Yaffe, M. B. Proteomic screen finds pSer/pThr-binding domain localizing Plk1 to mitotic substrates. Science 299, 1228–1231 (2003)
    Article ADS CAS Google Scholar
  13. Elia, A. E. et al. The molecular basis for phosphodependent substrate targeting and regulation of Plks by the Polo-box domain. Cell 115, 83–95 (2003)
    Article CAS Google Scholar
  14. Holloway, S. L., Glotzer, M., King, R. W. & Murray, A. W. Anaphase is initiated by proteolysis rather than by the inactivation of maturation-promoting factor. Cell 73, 13393–13402 (1993)
    Article Google Scholar
  15. Stemmann, O., Zou, H., Gerber, S. A., Gygi, S. P. & Kirschner, M. W. Dual inhibition of sister chromatid separation at metaphase. Cell 107, 715–726 (2001)
    Article CAS Google Scholar
  16. Colbran, R. J., Fong, Y. L., Schworer, C. M. & Soderling, T. R. Regulatory interactions of the calmodulin-binding, inhibitory, and autophosphorylation domains of Ca2+/calmodulin-dependent protein kinase II. J. Biol. Chem. 263, 18145–18151 (1988)
    CAS PubMed Google Scholar
  17. Zachariae, W. Emi1 and Erp1: who can stop these eggs? Dev. Cell 8, 301–303 (2005)
    Article CAS Google Scholar
  18. Ohsumi, K., Koyanagi, A., Yamamoto, T. M., Gotoh, T. & Kishimoto, T. Emi1-mediated M-phase arrest in Xenopus eggs is distinct from cytostatic factor arrest. Proc. Natl Acad. Sci. USA 101, 12531–12536 (2004)
    Article ADS CAS Google Scholar
  19. Tung, J. J. et al. A role for the anaphase-promoting complex inhibitor Emi2/XErp1, a homolog of early mitotic inhibitor 1, in cytostatic factor arrest of Xenopus eggs. Proc. Natl Acad. Sci. USA 102, 4318–4323 (2005)
    Article ADS CAS Google Scholar
  20. Murray, A. W. Cell cycle extracts. Methods Cell Biol. 36, 581–605 (1991)
    Article CAS Google Scholar
  21. Desai, A., Murray, A., Mitchison, T. J. & Walczak, C. E. The use of Xenopus egg extracts to study mitotic spindle assembly and function in vitro. Methods Cell Biol. 61, 385–412 (1999)
    Article CAS Google Scholar
  22. Funabiki, H. & Murray, A. W. The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell 102, 411–424 (2000)
    Article CAS Google Scholar

Download references