Critical role for the p110α phosphoinositide-3-OH kinase in growth and metabolic regulation (original) (raw)

• Shayesteh, L. et al. PIK3CA is implicated as an oncogene in ovarian cancer. Nature Genet. 21, 99–102 (1999)
  Article CAS PubMed Google Scholar
• Samuels, Y. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science 304, 554 (2004)
  Article CAS PubMed Google Scholar
• Vanhaesebroeck, B., Ali, K., Bilancio, A., Geering, B. & Foukas, L. C. Signalling by PI3K isoforms: Insights from gene-targeted mice. Trends Biochem. Sci. 30, 194–204 (2005)
  Article CAS PubMed Google Scholar
• Bi, L., Okabe, I., Bernard, D. J., Wynshaw-Boris, A. & Nussbaum, R. L. Proliferative defect and embryonic lethality in mice homozygous for a deletion in the p110α subunit of phosphoinositide 3-kinase. J. Biol. Chem. 274, 10963–10968 (1999)
  Article CAS PubMed Google Scholar
• Bi, L., Okabe, I., Bernard, D. J. & Nussbaum, R. L. Early embryonic lethality in mice deficient in the p110β catalytic subunit of PI 3-kinase. Mamm. Genome 13, 169–172 (2002)
  CAS PubMed Google Scholar
• Brachmann, S. M., Ueki, K., Engelman, J. A., Kahn, R. C. & Cantley, L. C. Phosphoinositide 3-kinase catalytic subunit deletion and regulatory subunit deletion have opposite effects on insulin sensitivity in mice. Mol. Cell. Biol. 25, 1596–1607 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Fruman, D. A. et al. Hypoglycemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α. Nature Genet. 26, 379–382 (2000)
  Article CAS PubMed Google Scholar
• Dupont, J. & Holzenberger, M. Biology of insulin-like growth factors in development. Birth Defects Res. C Embryo Today 69, 257–271 (2003)
  Article CAS PubMed Google Scholar
• Lawlor, M. A. et al. Essential role of PDK1 in regulating cell size and development in mice. EMBO J. 21, 3728–3738 (2002)
  Article CAS PubMed PubMed Central Google Scholar
• Kozma, S. C. & Thomas, G. Regulation of cell size in growth development and human disease: PI3K, PKB and S6K. Bioessays 24, 65–71 (2002)
  Article CAS PubMed Google Scholar
• Choudhury, A. I. et al. The role of insulin receptor substrate 2 in hypothalamic and β cell function. J. Clin. Invest. 115, 940–950 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Bouret, S. G., Draper, S. J. & Simerly, R. B. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 304, 108–110 (2004)
  Article ADS CAS PubMed Google Scholar
• White, M. F. Insulin signaling in health and disease. Science 302, 1710–1711 (2003)
  Article ADS CAS PubMed Google Scholar
• Niswender, K. D. et al. Intracellular signalling: Key enzyme in leptin-induced anorexia. Nature 413, 794–795 (2001)
  Article ADS CAS PubMed Google Scholar
• Niswender, K. D. et al. Insulin activation of phosphatidylinositol 3-kinase in the hypothalamic arcuate nucleus: A key mediator of insulin-induced anorexia. Diabetes 52, 227–231 (2003)
  Article CAS PubMed Google Scholar
• Xu, A. W. et al. PI3K integrates the action of insulin and leptin on hypothalamic neurons. J. Clin. Invest. 115, 951–958 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Withers, D. J. Insulin receptor substrate proteins and neuroendocrine function. Biochem. Soc. Trans. 29, 525–529 (2001)
  Article CAS PubMed Google Scholar
• Cho, H. et al. Insulin resistance and a diabetes mellitus-like syndrome in mice lacking the protein kinase Akt2 (PKBβ). Science 292, 1728–1731 (2001)
  Article ADS CAS PubMed Google Scholar
• Wang, Q., Bilan, P. J., Tsakiridis, T., Hinek, A. & Klip, A. Actin filaments participate in the relocalization of phosphatidylinositol 3-kinase to glucose transporter-containing compartments and in the stimulation of glucose uptake in 3T3–L1 adipocytes. Biochem. J. 331, 917–928 (1998)
  Article CAS PubMed PubMed Central Google Scholar
• Asano, T. et al. p110β is up-regulated during differentiation of 3T3–L1 cells and contributes to the highly insulin-responsive glucose transport activity. J. Biol. Chem. 275, 17671–17676 (2000)
  Article CAS PubMed Google Scholar
• Roche, S., Downward, J., Raynal, P. & Courtneidge, S. A. A function for phosphatidylinositol 3-kinase β (p85α-p110β) in fibroblasts during mitogenesis: Requirement for insulin- and lysophosphatidic acid-mediated signal transduction. Mol. Cell. Biol. 18, 7119–7129 (1998)
  Article CAS PubMed PubMed Central Google Scholar
• Hooshmand-Rad, R. et al. The PI 3-kinase isoforms p110α and p110β have differential roles in PDGF- and insulin-mediated signaling. J. Cell Sci. 113, 207–214 (2000)
  CAS PubMed Google Scholar
• Jackson, S. P. et al. PI 3-kinase p110β: A new target for antithrombotic therapy. Nature Med. 11, 507–514 (2005)
  Article CAS PubMed Google Scholar
• Beeton, C. A., Chance, E. M., Foukas, L. C. & Shepherd, P. R. Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110α and p110β catalytic subunits of class-Ia phosphoinositide 3-kinases. Biochem. J. 350, 353–359 (2000)
  Article CAS PubMed PubMed Central Google Scholar
• Kurosu, H. et al. Heterodimeric phosphoinositide 3-kinase consisting of p85 and p110β is synergistically activated by the βγ subunits of G proteins and phosphotyrosyl peptide. J. Biol. Chem. 272, 24252–24256 (1997)
  Article CAS PubMed Google Scholar
• Kubo, H., Hazeki, K., Takasuga, S. & Hazeki, O. Specific role of p85/p110β in GTP-binding protein-mediated activation of Akt. Biochem. J. 392, 607–614 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Pollak, M. N., Schernhammer, E. S. & Hankinson, S. E. Insulin-like growth factors and neoplasia. Nature Rev. Cancer 4, 505–518 (2004)
  Article CAS Google Scholar
• Drees, B. E., Mills, G. B., Rommel, C. & Prestwich, G. D. Therapeutic potential of phosphoinositide 3-kinase inhibitors. Expert Opin. Ther. Patents 14, 703–732 (2004)
  Article CAS Google Scholar
• Amaravadi, R. & Thompson, C. B. The survival kinases Akt and Pim as potential pharmacological targets. J. Clin. Invest. 115, 2618–2624 (2005)
  Article CAS PubMed PubMed Central Google Scholar
• Klippel, A., Escobedo, J. A., Hirano, M. & Williams, L. T. The interaction of small domains between the subunits of phosphatidylinositol 3-kinase determines enzyme activity. Mol. Cell. Biol. 14, 2675–2685 (1994)
  Article CAS PubMed PubMed Central Google Scholar