p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload (original) (raw)

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Acknowledgements

We thank E. Fujita, R. Kobayashi and M. Ikeda for technical support. This work was supported by a Grant-in-Aid for Scientific Research on Priority Areas and for Exploratory Research, Ministry of Education, Culture, Sports, Science and Technology; Health and Labour Sciences Research Grants; Research on Measures for Intractable Diseases; Grants from Goho Life Sciences International Fund; an Academic Award of the Mochida Memorial Foundation and Uehara Memorial Foundation (to I.K.); and grants from the Suzuken Memorial Foundation, the NOVARTIS Foundation and the Ministry of Education, Culture, Sports, Science and Technology of Japan (to T.M.).

Author Contributions M.S., T.M., H.T., H.M., M.O., Y.Q., H.A., K.T., Y.K., M.H., I.S. and Y.Z. performed the experiments. T.A., H.H., S.T. and J.D.M. provided reagents or mice. M.S., T.M. and I.K. designed and prepared the manuscript. I.K. planned and supervised the project.

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Author notes

  1. Masanori Sano and Tohru Minamino: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiovascular Science and Medicine, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba 260-8670, Japan,
    Masanori Sano, Tohru Minamino, Haruhiro Toko, Hideyuki Miyauchi, Masayuki Orimo, Yingjie Qin, Hiroshi Akazawa, Kaoru Tateno, Yosuke Kayama, Mutsuo Harada, Ippei Shimizu & Issei Komuro
  2. Stem Cell Translational Research, Kobe Institute of Biomedical Research and Innovation/RIKEN Center for Developmental Biology, 2-2 Minatojima-Minamimachi, Chuo-ku, Kobe 650-0047, Japan,
    Takayuki Asahara
  3. Department of Molecular Medicine, Sapporo Medical University, S1 W17, Chuo-ku, Sapporo 060-8556, Japan,
    Hirofumi Hamada
  4. Division of Experimental Immunology, Institute for Genome Research, University of Tokushima, 3-18-15 Kuramoto, Tokushima 770-8503, Japan,
    Shuhei Tomita
  5. Department of Pediatrics, Division of Molecular Cardiovascular Biology, Children’s Hospital Medical Center, 3333 Burnet Avenue, Cincinnati, Ohio 45229-3039, USA,
    Jeffrey D. Molkentin
  6. Shanghai Institute of Cardiovascular Diseases, Zhongshan Hospital and Institutes of Biomedical Sciences, Fudan University, 180 Feng Lin Road, Shanghai 200032, China,
    Yunzeng Zou

Authors

  1. Masanori Sano
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  2. Tohru Minamino
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  3. Haruhiro Toko
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  4. Hideyuki Miyauchi
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  5. Masayuki Orimo
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  6. Yingjie Qin
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  7. Hiroshi Akazawa
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  8. Kaoru Tateno
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  9. Yosuke Kayama
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  10. Mutsuo Harada
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  11. Ippei Shimizu
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  12. Takayuki Asahara
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  13. Hirofumi Hamada
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  14. Shuhei Tomita
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  15. Jeffrey D. Molkentin
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  16. Yunzeng Zou
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  17. Issei Komuro
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Corresponding author

Correspondence toIssei Komuro.

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Supplementary information

Supplementary Information

This file contains Supplementary Figures 1–11 with Legends, Supplementary Methods describing all reagents used as well as detailed protocols and additional references. (PDF 1083 kb)

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Sano, M., Minamino, T., Toko, H. et al. p53-induced inhibition of Hif-1 causes cardiac dysfunction during pressure overload.Nature 446, 444–448 (2007). https://doi.org/10.1038/nature05602

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