Structural basis for AMP binding to mammalian AMP-activated protein kinase (original) (raw)

• Kahn, B. B., Alquier, T., Carling, D. & Hardie, D. G. AMP-activated protein kinase: Ancient energy gauge provides clues to modern understanding of metabolism. Cell Metab. 1, 15–25 (2005)
  Article CAS Google Scholar
• Hardie, D. G., Carling, D. & Carlson, M. The AMP-activated/SNF1 protein kinase subfamily: metabolic sensors of the eukaryotic cell? Annu. Rev. Biochem. 67, 821–855 (1998)
  Article CAS Google Scholar
• Hardie, D. G. & Carling, D. The AMP-activated protein kinase: Fuel gauge of the mammalian cell. Eur. J. Biochem. 246, 259–273 (1997)
  Article CAS Google Scholar
• Yeh, L., Lee, K. & Kim, K. Regulation of rat liver acetyl-CoA carboxylase. Regulation of phosphorylation and inactivation of acetyl-CoA carboxylase by adenylate energy charge. J. Biol. Chem. 255, 2308–2314 (1980)
  CAS PubMed Google Scholar
• Hardie, D. G., Carling, D. & Sim, A. T. R. The AMP-activated protein kinase-a multisubstrate regulator of lipid metabolism. Trends Biochem. Sci. 14, 20–23 (1989)
  Article CAS Google Scholar
• Minokoshi, Y. et al. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 428, 569–574 (2004)
  Article ADS CAS Google Scholar
• Viollet, B. et al. The AMP-activated protein kinase α2 catalytic subunit controls whole body insulin sensitivity. J. Clin. Invest. 111, 91–98 (2003)
  Article CAS Google Scholar
• Zong, H. et al. AMP kinase is required for mitochondrial biogenesis in skeletal muscle in response to chronic energy deprivation. Proc. Natl Acad. Sci. USA 99, 15983–15987 (2002)
  Article ADS CAS Google Scholar
• Minokoshi, Y. et al. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 415, 339–343 (2002)
  Article ADS CAS Google Scholar
• Yamauchi, T. et al. Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nature Med. 8, 1288–1295 (2002)
  Article CAS Google Scholar
• Watt, M. J. et al. CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK. Nature Med. 12, 541–548 (2006)
  Article CAS Google Scholar
• Zhou, G. et al. Role of AMP-activated protein kinase in mechanism of metformin action. J. Clin. Invest. 108, 1167–1174 (2001)
  Article CAS Google Scholar
• Shaw, R. J. et al. The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin. Science 310, 1642–1646 (2005)
  Article ADS CAS Google Scholar
• Sanders, M. J., Grondin, P. O., Hegarty, B. D., Snowden, M. A. & Carling, D. Investigating the mechanism for AMP activation of the AMP-activated protein kinase cascade. Biochem. J. 403, 139–148 (2007)
  Article CAS Google Scholar
• Carling, D. The AMP-activated protein kinase cascade—a unifying system for energy control. Trends Biochem. Sci. 29, 18–24 (2004)
  Article CAS Google Scholar
• Woods, A. et al. Characterization of AMP-activated protein kinase β subunit and γ subunit—assembly of the heterotrimeric complex in vitro. J. Biol. Chem. 271, 10282–10290 (1996)
  Article CAS Google Scholar
• Hudson, E. R. et al. A novel domain in AMP-activated protein kinase causes glycogen storage bodies similar to those seen in hereditary cardiac arrhythmias. Curr. Biol. 13, 861–866 (2003)
  Article CAS Google Scholar
• Iseli, T. J. et al. AMP-activated protein kinase β subunit tethers α and γ subunits by its C-terminal sequence (186–270). J. Biol. Chem. 280, 13395–13400 (2005)
  Article CAS Google Scholar
• Townley, R. & Shapiro, L. Crystal structures of the adenylate sensor from fission yeast AMP-activated protein kinase. Science 315, 1726–1729 (2007)
  Article ADS CAS Google Scholar
• Rudolph, M. J., Amodeo, G. A., Bai, Y. & Tong, L. Crystal structure of the protein kinase domain of yeast AMP-activated protein kinase Snf1. Biochem. Biophys. Res. Commun. 337, 1224–1228 (2005)
  Article CAS Google Scholar
• Corkey, B. E., Duszynski, J., Rich, T. L., Matschinsky, B. & Williamson, J. R. Regulation of free and bound magnesium in rat hepatocytes and isolated mitochondria. J. Biol. Chem. 261, 2567–2574 (1986)
  CAS PubMed Google Scholar
• Scott, J. W. et al. CBS domains form energy-sensing modules whose binding of adenosine ligands is disrupted by disease mutations. J. Clin. Invest. 113, 274–284 (2004)
  Article CAS Google Scholar
• Chen, Z. et al. AMPK signaling in contracting human skeletal muscle: acetyl-CoA carboxylase and NO synthase phosphorylation. Am. J. Physiol. Endocrinol. Metab. 279, 1202–1206 (2000)
  Article Google Scholar
• Fujii, N. et al. Exercise induces isoform-specific increase in 5′AMP-activated protein kinase activity in human skeletal muscle. Biochem. Biophys. Res. Commun. 273, 1150–1155 (2000)
  Article CAS Google Scholar
• McConell, G. K. et al. Short-term exercise training in humans reduces AMPK signalling during prolonged exercise independent of muscle glycogen. J. Physiol. 568, 665–676 (2005)
  Article CAS Google Scholar
• Fryer, L. G., Parbu-Patel, A. & Carling, D. The anti-diabetic drugs rosiglitazone and metformin stimulate AMP-activated protein kinase through distinct signaling pathways. J. Biol. Chem. 277, 25226–25232 (2002)
  Article CAS Google Scholar
• Gollob, M. H. et al. Identification of a gene responsible for familial Wolff–Parkinson–White syndrome. N. Engl. J. Med. 344, 1823–1831 (2001)
  Article CAS Google Scholar
• Arad, M. et al. Constitutively active AMP kinase mutations cause glycogen storage disease mimicking hypertrophic cardiomyopathy. J. Clin. Invest. 109, 357–362 (2002)
  Article CAS Google Scholar
• Blair, E., Redwood, C., Ashrafian, H., Ostman-Smith, I. & Watkins, H. Mutations in the γ2 subunit of AMP-activated protein kinase cause familial hypertrophic cardiomyopathy: evidence for the central role of energy compromise in disease pathogenesis. Hum. Mol. Genet. 10, 1215–1220 (2001)
  Article CAS Google Scholar
• Adams, J. et al. Intrasteric control of AMPK via the γ1 subunit AMP allosteric regulatory site. Protein Sci. 13, 155–165 (2004)
  Article CAS Google Scholar
• Neumann, D., Woods, A., Carling, D., Wallimann, T. & Schlattner, U. Mammalian AMP-activated protein kinase: functional, heterotrimeric complexes by co-expression of subunits in Escherichia coli. Protein Expr. Purif. 30, 230–237 (2003)
  Article CAS Google Scholar
• Otwinowski, Z. & Minor, W. in Data Collection and Processing (eds Sawyer, L., Isaacs, N. & Bailey, S.) 556–562 (SERC Daresbury Laboratory, Warrington, 1993)
  Google Scholar
• Navaza, J. AMoRe: an Automated Package for Molecular Replacement. Acta Crystallogr. A 50, 157–163 (1994)
  Article Google Scholar
• CCP4. The CCP4 suite: programs for protein crystallography. Acta Crystallogr. D 50, 760–763 (1994)
• Brunger, A. T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D 54, 905–921 (1998)
  Article CAS Google Scholar
• Jones, T. A., Zhou, J. Y., Cowan, S. W. & Kjeldgaard, M. Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A 47, 110–119 (1991)
  Article Google Scholar
• Jameson, D. M. & Eccleston, J. F. Fluorescent nucleotide analogs: synthesis and applications. Methods Enzymol. 278, 363–390 (1997)
  Article CAS Google Scholar