Resistance to therapy caused by intragenic deletion in BRCA2 (original) (raw)
Farmer, H. et al. Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy. Nature434, 917–921 (2005) ArticleCASADS Google Scholar
Bryant, H. E. et al. Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase. Nature434, 913–917 (2005) ArticleCASADS Google Scholar
Tutt, A. et al. Mutation in Brca2 stimulates error-prone homology-directed repair of DNA double-strand breaks occurring between repeated sequences. EMBO J.20, 4704–4716 (2001) ArticleCAS Google Scholar
Moynahan, M. E., Pierce, A. J. & Jasin, M. BRCA2 is required for homology-directed repair of chromosomal breaks. Mol. Cell7, 263–272 (2001) ArticleCAS Google Scholar
Domchek, S. M. & Weber, B. L. Clinical management of BRCA1 and BRCA2 mutation carriers. Oncogene25, 5825–5831 (2006) ArticleCAS Google Scholar
Gudmundsdottir, K. & Ashworth, A. The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability. Oncogene25, 5864–5874 (2006) ArticleCAS Google Scholar
Davies, O. R. & Pellegrini, L. Interaction with the BRCA2 C terminus protects RAD51-DNA filaments from disassembly by BRC repeats. Nat. Struct. Mol. Biol.14, 475–483 (2007) Article Google Scholar
Esashi, F., Galkin, V. E., Yu, X., Egelman, E. H. & West, S. C. Stabilization of RAD51 nucleoprotein filaments by the C-terminal region of BRCA2. Nat. Struct. Mol. Biol.14, 468–474 (2007) ArticleCAS Google Scholar
Ratnam, K. & Low, J. A. Current development of clinical inhibitors of poly(ADP-ribose) polymerase in oncology. Clin. Cancer Res.13, 1383–1388 (2007) ArticleCAS Google Scholar
Goggins, M. et al. Germline BRCA2 gene mutations in patients with apparently sporadic pancreatic carcinomas. Cancer Res.56, 5360–5364 (1996) CASPubMed Google Scholar
Yang, H. et al. BRCA2 function in DNA binding and recombination from a BRCA2–DSS1-ssDNA structure. Science297, 1837–1848 (2002) ArticleCASADS Google Scholar
Spain, B. H., Larson, C. J., Shihabuddin, L. S., Gage, F. H. & Verma, I. M. Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations. Proc. Natl Acad. Sci. USA96, 13920–13925 (1999) ArticleCASADS Google Scholar
Abaji, C., Cousineau, I. & Belmaaza, A. BRCA2 regulates homologous recombination in response to DNA damage: implications for genome stability and carcinogenesis. Cancer Res.65, 4117–4125 (2005) ArticleCAS Google Scholar
McCabe, N. et al. BRCA2-deficient CAPAN-1 cells are extremely sensitive to the inhibition of poly(ADP-ribose) polymerase: an issue of potency. Cancer Biol. Ther.4, 934–936 (2005) ArticleCAS Google Scholar
Tutt, A. N. et al. Exploiting the DNA repair defect in BRCA mutant cells in the design of new therapeutic strategies for cancer. Cold Spring Harb. Symp. Quant. Biol.70, 139–148 (2005) ArticleCAS Google Scholar
Furuta, T. et al. Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes. J. Biol. Chem.278, 20303–20312 (2003) ArticleCAS Google Scholar
Weinstock, D. M., Elliott, B. & Jasin, M. A model of oncogenic rearrangements: differences between chromosomal translocation mechanisms and simple double-strand break repair. Blood107, 777–780 (2006) ArticleCAS Google Scholar
Saeki, H. et al. Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions. Proc. Natl Acad. Sci. USA103, 8768–8773 (2006) ArticleCASADS Google Scholar
Cass, I. et al. Improved survival in women with BRCA-associated ovarian carcinoma. Cancer97, 2187–2195 (2003) ArticleCAS Google Scholar
Pal, T., Permuth-Wey, J., Kapoor, R., Cantor, A. & Sutphen, R. Improved survival in BRCA2 carriers with ovarian cancer. Fam. Cancer6, 113–119 (2007) ArticleCAS Google Scholar
Wang, D. & Lippard, S. J. Cellular processing of platinum anticancer drugs. Nature Rev. Drug Discov.4, 307–320 (2005) ArticleCAS Google Scholar
Hirschhorn, R. In vivo reversion to normal of inherited mutations in humans. J. Med. Genet.40, 721–728 (2003) ArticleCAS Google Scholar
Xia, B. et al. Fanconi anemia is associated with a defect in the BRCA2 partner PALB2. Nature Genet.39, 159–161 (2007) ArticleCAS Google Scholar
Daniels, M. J., Wang, Y., Lee, M. & Venkitaraman, A. R. Abnormal cytokinesis in cells deficient in the breast cancer susceptibility protein BRCA2. Science306, 876–879 (2004) ArticleCASADS Google Scholar
Vichai, V. & Kirtikara, K. Sulforhodamine B colorimetric assay for cytotoxicity screening. Nature Protocols1, 1112–1116 (2006) ArticleCAS Google Scholar
Gudmundsdottir, K., Lord, C. J., Witt, E., Tutt, A. N. & Ashworth, A. DSS1 is required for RAD51 focus formation and genomic stability in mammalian cells. EMBO Rep.5, 989–993 (2004) ArticleCAS Google Scholar
Reis-Filho, J. S. et al. Pleomorphic lobular carcinoma of the breast: role of comprehensive molecular pathology in characterization of an entity. J. Pathol.207, 1–13 (2005) ArticleCAS Google Scholar
Poch, G. & Pancheva, S. N. Calculating slope and ED50 of additive dose–response curves, and application of these tabulated parameter values. J. Pharmacol. Toxicol. Methods33, 137–145 (1995) ArticleCAS Google Scholar
Bertwistle, D. et al. Nuclear location and cell cycle regulation of the BRCA2 protein. Cancer Res.57, 5485–5488 (1997) CASPubMed Google Scholar
Lambros, M. B. et al. Unlocking pathology archives for molecular genetic studies: a reliable method to generate probes for chromogenic and fluorescent in situ hybridization. Lab. Invest.86, 398–408 (2006) ArticleCAS Google Scholar