The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins (original) (raw)

References

  1. Schmidt, J. V. & Bradfield, C. A. Ah receptor signaling pathways. Annu. Rev. Cell Dev. Biol. 12, 55–89 (1996)
    Article CAS Google Scholar
  2. Harper, P. A., Riddick, D. S. & Okey, A. B. Regulating the regulator: factors that control levels and activity of the aryl hydrocarbon receptor. Biochem. Pharmacol. 72, 267–279 (2006)
    Article CAS Google Scholar
  3. Schmidt, J. V., Su, G. H., Reddy, J. K., Simon, M. C. & Bradfield, C. A. Characterization of a murine Ahr null allele: involvement of the Ah receptor in hepatic growth and development. Proc. Natl Acad. Sci. USA 93, 6731–6736 (1996)
    Article ADS CAS Google Scholar
  4. Fernandez-Salguero, P. et al. Immune system impairment and hepatic fibrosis in mice lacking the dioxin-binding Ah receptor. Science 268, 722–726 (1995)
    Article ADS CAS Google Scholar
  5. Mimura, J. et al. Loss of teratogenic response to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in mice lacking the Ah (dioxin) receptor. Genes Cells 2, 645–654 (1997)
    Article CAS Google Scholar
  6. Ivanov, I. I. et al. The orphan nuclear receptor RORγt directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126, 1121–1133 (2006)
    Article CAS Google Scholar
  7. Dumoutier, L., Van Roost, E., Colau, D. & Renauld, J. C. Human interleukin-10-related T cell-derived inducible factor: molecular cloning and functional characterization as an hepatocyte-stimulating factor. Proc. Natl Acad. Sci. USA 97, 10144–10149 (2000)
    Article ADS CAS Google Scholar
  8. Zheng, Y. et al. Interleukin-22, a TH17 cytokine, mediates IL-23-induced dermal inflammation and acanthosis. Nature 445, 648–651 (2007)
    Article CAS Google Scholar
  9. Liang, S. C. et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J. Exp. Med. 203, 2271–2279 (2006)
    Article CAS Google Scholar
  10. Boniface, K. et al. IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes. J. Immunol. 174, 3695–3702 (2005)
    Article CAS Google Scholar
  11. Radaeva, S., Sun, R., Pan, H. N., Hong, F. & Gao, B. Interleukin 22 (IL-22) plays a protective role in T cell-mediated murine hepatitis: IL-22 is a survival factor for hepatocytes via STAT3 activation. Hepatology 39, 1332–1342 (2004)
    Article CAS Google Scholar
  12. Zenewicz, L. A. et al. Interleukin-22 but not interleukin-17 provides protection to hepatocytes during acute liver inflammation. Immunity 27, 647–659 (2007)
    Article CAS Google Scholar
  13. Rannug, A. & Fritsche, E. The aryl hydrocarbon receptor and light. Biol. Chem. 387, 1149–1157 (2006)
    Article CAS Google Scholar
  14. Hirota, K. et al. Preferential recruitment of CCR6-expressing Th17 cells to inflamed joints via CCL20 in rheumatoid arthritis and its animal model. J. Exp. Med. 204, 2803–2812 (2007)
    Article CAS Google Scholar
  15. Acosta-Rodriguez, E. V. et al. Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells. Nature Immunol. 8, 639–646 (2007)
    Article CAS Google Scholar
  16. Kerkvliet, N. I. Recent advances in understanding the mechanisms of TCDD immunotoxicity. Int. Immunopharmacol. 2, 277–291 (2002)
    Article CAS Google Scholar
  17. Funatake, C. J., Marshall, N. B., Steppan, L. B., Mourich, D. V. & Kerkvliet, N. I. Cutting edge: activation of the aryl hydrocarbon receptor by 2,3,7,8-tetrachlorodibenzo-p-dioxin generates a population of CD4+CD25+cells with characteristics of regulatory T cells. J. Immunol. 175, 4184–4188 (2005)
    Article CAS Google Scholar
  18. Minamimura, K., Gao, W. & Maki, T. CD4+ regulatory T cells are spared from deletion by antilymphocyte serum, a polyclonal anti-T cell antibody. J. Immunol. 176, 4125–4132 (2006)
    Article CAS Google Scholar
  19. Cox, A. L. et al. Lymphocyte homeostasis following therapeutic lymphocyte depletion in multiple sclerosis. Eur. J. Immunol. 35, 3332–3342 (2005)
    Article CAS Google Scholar
  20. Nguyen, L. P. & Bradfield, C. A. The search for endogenous activators of the aryl hydrocarbon receptor. Chem. Res. Toxicol. 21, 102–116 (2007)
    Article Google Scholar
  21. Katiyar, S. K., Matsui, M. S. & Mukhtar, H. Ultraviolet-B exposure of human skin induces cytochromes P450 1A1 and 1B1. J. Invest. Dermatol. 114, 328–333 (2000)
    Article CAS Google Scholar
  22. Uyttenhove, C. & Van Snick, J. Development of an anti-IL-17A auto-vaccine that prevents experimental auto-immune encephalomyelitis. Eur. J. Immunol. 36, 2868–2874 (2006)
    Article CAS Google Scholar
  23. Langrish, C. L. et al. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233–240 (2005)
    Article CAS Google Scholar
  24. Kebir, H. et al. Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation. Nature Med. 13, 1173–1175 (2007)
    Article CAS Google Scholar
  25. Kreymborg, K. et al. IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis. J. Immunol. 179, 8098–8104 (2007)
    Article CAS Google Scholar
  26. Okey, A. B. An aryl hydrocarbon receptor odyssey to the shores of toxicology: the Deichmann lecture, International Congress of Toxicology-XI. Toxicol. Sci. 98, 5–38 (2007)
    Article CAS Google Scholar
  27. Tian, Y., Rabson, A. B. & Gallo, M. A. Ah receptor and NF-κB interactions: mechanisms and physiological implications. Chem. Biol. Interact. 141, 97–115 (2002)
    Article CAS Google Scholar
  28. Hilliard, B., Samoilova, E. B., Liu, T. S., Rostami, A. & Chen, Y. Experimental autoimmune encephalomyelitis in NF-κB-deficient mice: roles of NF-κB in the activation and differentiation of autoreactive T cells. J. Immunol. 163, 2937–2943 (1999)
    CAS PubMed Google Scholar
  29. Denison, M. S., Fisher, J. M. & Whitlock, J. P. Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer. Proc. Natl Acad. Sci. USA 85, 2528–2532 (1988)
    Article ADS CAS Google Scholar
  30. Veldhoen, M., Hocking, R. J., Flavell, R. A. & Stockinger, B. Signals mediated by transforming growth factor-β initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nature Immunol. 7, 1151–1156 (2006)
    Article CAS Google Scholar

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