The CRAC channel consists of a tetramer formed by Stim-induced dimerization of Orai dimers (original) (raw)

• Liou, J. et al. STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx. Curr. Biol. 15, 1235–1241 (2005)
  Article CAS Google Scholar
• Roos, J. et al. STIM1, an essential and conserved component of store-operated Ca2+ channel function. J. Cell Biol. 169, 435–445 (2005)
  Article CAS Google Scholar
• Feske, S. et al. A mutation in Orai1 causes immune deficiency by abrogating CRAC channel function. Nature 441, 179–185 (2006)
  Article ADS CAS Google Scholar
• Zhang, S. L. et al. Genome-wide RNAi screen of Ca2+ influx identifies genes that regulate Ca2+ release-activated Ca2+ channel activity. Proc. Natl Acad. Sci. USA 103, 9357–9362 (2006)
  Article ADS CAS Google Scholar
• Vig, M. et al. CRACM1 is a plasma membrane protein essential for store-operated Ca2+ entry. Science 312, 1220–1223 (2006)
  Article ADS CAS Google Scholar
• Cahalan, M. D. et al. Molecular basis of the CRAC channel. Cell Calcium 42, 133–144 (2007)
  Article CAS Google Scholar
• Lewis, R. S. The molecular choreography of a store-operated calcium channel. Nature 446, 284–287 (2007)
  Article ADS CAS Google Scholar
• Zhang, S. L. et al. STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane. Nature 437, 902–905 (2005)
  Article ADS CAS Google Scholar
• Wu, M. M., Buchanan, J., Luik, R. M. & Lewis, R. S. Ca2+ store depletion causes STIM1 to accumulate in ER regions closely associated with the plasma membrane. J. Cell Biol. 174, 803–813 (2006)
  Article CAS Google Scholar
• Prakriya, M. et al. Orai1 is an essential pore subunit of the CRAC channel. Nature 443, 230–233 (2006)
  Article ADS CAS Google Scholar
• Vig, M. et al. CRACM1 multimers form the ion-selective pore of the CRAC channel. Curr. Biol. 16, 2073–2079 (2006)
  Article CAS Google Scholar
• Yeromin, A. V. et al. Molecular identification of the CRAC channel by altered ion selectivity in a mutant of Orai. Nature 443, 226–229 (2006)
  Article ADS CAS Google Scholar
• Muik, M. et al. Dynamic coupling of the putative coiled-coil domain of ORAI1 with STIM1 mediates ORAI1 channel activation. J. Biol. Chem. 283, 8014–8022 (2008)
  Article CAS Google Scholar
• Gwack, Y. et al. Biochemical and functional characterization of Orai proteins. J. Biol. Chem. 282, 16232–16243 (2007)
  Article CAS Google Scholar
• Mignen, O., Thompson, J. L. & Shuttleworth, T. J. Orai1 subunit stoichiometry of the mammalian CRAC channel pore. J. Physiol. (Lond.) 586, 419–425 (2008)
  Article CAS Google Scholar
• Hoenderop, J. G. et al. Homo- and heterotetrameric architecture of the epithelial Ca2+ channels TRPV5 and TRPV6. EMBO J. 22, 776–785 (2003)
  Article CAS Google Scholar
• Kedei, N. et al. Analysis of the native quaternary structure of vanilloid receptor 1. J. Biol. Chem. 276, 28613–28619 (2001)
  Article CAS Google Scholar
• Raab-Graham, K. F. & Vandenberg, C. A. Tetrameric subunit structure of the native brain inwardly rectifying potassium channel Kir 2.2. J. Biol. Chem. 273, 19699–19707 (1998)
  Article CAS Google Scholar
• Ramjeesingh, M., Huan, L. J., Garami, E. & Bear, C. E. Novel method for evaluation of the oligomeric structure of membrane proteins. Biochem. J. 342, 119–123 (1999)
  Article CAS Google Scholar
• Huang, G. N. et al. STIM1 carboxyl-terminus activates native SOC, I crac and TRPC1 channels. Nature Cell Biol. 8, 1003–1010 (2006)
  Article CAS Google Scholar
• Zhang, S. L. et al. Store-dependent and -independent modes regulating CRAC channel activity of human Orai1 and Orai3. J. Biol. Chem. 283, 17662–17671 (2008)
  Article CAS Google Scholar
• Yeromin, A. V., Roos, J., Stauderman, K. A. & Cahalan, M. D. A store-operated calcium channel in Drosophila S2 cells. J. Gen. Physiol. 123, 167–182 (2004)
  Article CAS Google Scholar
• Ulbrich, M. H. & Isacoff, E. Y. Subunit counting in membrane-bound proteins. Nature Methods 4, 319–321 (2007)
  Article CAS Google Scholar
• Ji, W. et al. Functional stoichiometry of the unitary calcium-release-activated calcium channel. Proc. Natl Acad. Sci. USA doi: 10.1073/pnas.0806499105 (29 August 2008)
• Zacharias, D. A., Violin, J. D., Newton, A. C. & Tsien, R. Y. Partitioning of lipid-modified monomeric GFPs into membrane microdomains of live cells. Science 296, 913–916 (2002)
  Article ADS CAS Google Scholar
• Newbolt, A. et al. Membrane topology of an ATP-gated ion channel (P2X receptor). J. Biol. Chem. 273, 15177–15182 (1998)
  Article CAS Google Scholar
• Nielsen, P. A. et al. Molecular cloning, functional expression, and tissue distribution of a novel human gap junction-forming protein, connexin-31.9. Interaction with zona occludens protein-1. J. Biol. Chem. 277, 38272–38283 (2002)
  Article CAS Google Scholar
• Aschrafi, A., Sadtler, S., Niculescu, C., Rettinger, J. & Schmalzing, G. Trimeric architecture of homomeric P2X2 and heteromeric P2X1+2 receptor subtypes. J. Mol. Biol. 342, 333–343 (2004)
  Article CAS Google Scholar
• Demuro, A. & Parker, I. Optical single-channel recording: imaging Ca2+ flux through individual ion channels with high temporal and spatial resolution. J. Biomed. Opt. 10, 11002 (2005)
  Article Google Scholar
• Parker, I., Gundersen, C. B. & Miledi, R. A transient inward current elicited by hyperpolarization during serotonin activation in Xenopus oocytes. Proc. R. Soc. Lond. B 223, 279–292 (1985)
  Article ADS CAS Google Scholar
• Dargan, S. L., Demuro, A. & Parker, I. Imaging Ca2+ signals in Xenopus oocytes. Methods Mol. Biol. 322, 103–119 (2006)
  Article CAS Google Scholar