Tumours with PI3K activation are resistant to dietary restriction (original) (raw)
Moreschi, C. Beziehung zwischen Ernahrung und Tumorwachstum. Zeitschrift f. Immunitätsforsch. Originale2, 651–675 (1909) Google Scholar
Rous, P. The influence of diet on transplanted and spontaneous tumors. J. Exp. Med.20, 351–413 (1914) Google Scholar
McCay, C. M., Crowell, M. F. & Maynard, L. A. The effect of retarded growth upon the length of life span and upon the ultimate body size. J. Nutr.10, 63–79 (1935) ArticleCAS Google Scholar
Tannenbaum, A. & Silverstone, H. The influence of the degree of caloric restriction on the formation of skin tumors and hepatomas in mice. Cancer Res.9, 724–727 (1949) CASPubMed Google Scholar
Tannenbaum, A. & Silverstone, H. Effect of limited food intake on survival of mice bearing spontaneous mammary carcinoma and on the incidence of lung metastases. Cancer Res.13, 532–536 (1953) CASPubMed Google Scholar
Cheney, K. E. et al. Survival and disease patterns in C57BL/6J mice subjected to undernutrition. Exp. Gerontol.15, 237–258 (1980) ArticleCAS Google Scholar
Weindruch, R. & Walford, R. L. Dietary restriction in mice beginning at 1 year of age: effect on life-span and spontaneous cancer incidence. Science215, 1415–1418 (1982) ArticleADSCAS Google Scholar
Klurfeld, D. M., Welch, C. B., Davis, M. J. & Kritchevsky, D. Determination of degree of energy restriction necessary to reduce DMBA-induced mammary tumorigenesis in rats during the promotion phase. J. Nutr.119, 286–291 (1989) ArticleCAS Google Scholar
Zhu, Z., Haegele, A. D. & Thompson, H. J. Effect of caloric restriction on pre-malignant and malignant stages of mammary carcinogenesis. Carcinogenesis18, 1007–1012 (1997) ArticleCAS Google Scholar
Kritchevsky, D. Caloric restriction and cancer. J. Nutr. Sci. Vitaminol. (Tokyo)47, 13–19 (2001) ArticleCAS Google Scholar
Thompson, H. J., Zhu, Z. & Jiang, W. Dietary energy restriction in breast cancer prevention. J. Mammary Gland Biol. Neoplasia8, 133–142 (2003) Article Google Scholar
Sell, C. Caloric restriction and insulin-like growth factors in aging and cancer. Horm. Metab. Res.35, 705–711 (2003) ArticleCAS Google Scholar
Cheney, K. E. et al. The effect of dietary restriction of varying duration on survival, tumor patterns, immune function, and body temperature in B10C3F1 female mice. J. Gerontol.38, 420–430 (1983) ArticleCAS Google Scholar
Pugh, T. D., Oberley, T. D. & Weindruch, R. Dietary intervention at middle age: caloric restriction but not dehydroepiandrosterone sulfate increases lifespan and lifetime cancer incidence in mice. Cancer Res.59, 1642–1648 (1999) CASPubMed Google Scholar
Ruggeri, B. A., Klurfeld, D. M., Kritchevsky, D. & Furlanetto, R. W. Caloric restriction and 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in rats: alterations in circulating insulin, insulin-like growth factors I and II, and epidermal growth factor. Cancer Res.49, 4130–4134 (1989) CASPubMed Google Scholar
Breese, C. R., Ingram, R. L. & Sonntag, W. E. Influence of age and long-term dietary restriction on plasma insulin-like growth factor-1 (IGF-1), IGF-1 gene expression, and IGF-1 binding proteins. J. Gerontol.46, B180–B187 (1991) ArticleCAS Google Scholar
Miller, F. R., Santner, S. J., Tait, L. & Dawson, P. J. MCF10DCIS.com xenograft model of human comedo ductal carcinoma in situ . J. Natl. Cancer Inst.92, 1185–1186 (2000) ArticleCAS Google Scholar
Manning, B. D. & Cantley, L. C. AKT/PKB signaling: navigating downstream. Cell129, 1261–1274 (2007) ArticleCAS Google Scholar
Engelman, J. A., Luo, J. & Cantley, L. C. The evolution of phosphatidylinositol 3-kinases as regulators of growth and metabolism. Nature Rev. Genet.7, 606–619 (2006) ArticleCAS Google Scholar
Salmena, L., Carracedo, A. & Pandolfi, P. P. Tenets of PTEN tumor suppression. Cell133, 403–414 (2008) ArticleCAS Google Scholar
Samuels, Y. et al. Mutant PIK3CA promotes cell growth and invasion of human cancer cells. Cancer Cell7, 561–573 (2005) ArticleCAS Google Scholar
Kang, S., Bader, A. G. & Vogt, P. K. Phosphatidylinositol 3-kinase mutations identified in human cancer are oncogenic. Proc. Natl Acad. Sci. USA102, 802–807 (2005) ArticleADSCAS Google Scholar
Saal, L. H. et al. PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma. Cancer Res.65, 2554–2559 (2005) ArticleCAS Google Scholar
Zhao, J. J. et al. The oncogenic properties of mutant p110α and p110β phosphatidylinositol 3-kinases in human mammary epithelial cells. Proc. Natl Acad. Sci. USA102, 18443–18448 (2005) ArticleADSCAS Google Scholar
Samuels, Y. et al. High frequency of mutations of the PIK3CA gene in human cancers. Science304, 554 (2004) ArticleCAS Google Scholar
Rodriguez-Viciana, P. et al. Phosphatidylinositol-3-OH kinase as a direct target of Ras. Nature370, 527–532 (1994) ArticleADSCAS Google Scholar
Gupta, S. et al. Binding of ras to phosphoinositide 3-kinase p110α is required for ras-driven tumorigenesis in mice. Cell129, 957–968 (2007) ArticleCAS Google Scholar
Radu, A., Neubauer, V., Akagi, T., Hanafusa, H. & Georgescu, M. M. PTEN induces cell cycle arrest by decreasing the level and nuclear localization of cyclin D1. Mol. Cell. Biol.23, 6139–6149 (2003) ArticleCAS Google Scholar
Wang, S. et al. Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer Cell4, 209–221 (2003) ArticleCAS Google Scholar
Johnson, L. et al. Somatic activation of the K-ras oncogene causes early onset lung cancer in mice. Nature410, 1111–1116 (2001) ArticleADSCAS Google Scholar
Ventura, A. et al. Restoration of p53 function leads to tumour regression in vivo . Nature445, 661–665 (2007) ArticleCAS Google Scholar
Fu, Z. & Tindall, D. J. FOXOs, cancer and regulation of apoptosis. Oncogene27, 2312–2319 (2008) ArticleCAS Google Scholar
Kim, D. H. et al. mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery. Cell110, 163–175 (2002) ArticleCAS Google Scholar
Kalaany, N. Y. et al. LXRs regulate the balance between fat storage and oxidation. Cell Metab.1, 231–244 (2005) ArticleCAS Google Scholar
Wapnir, I. L., Wartenberg, D. E. & Greco, R. S. Three dimensional staging of breast cancer. Breast Cancer Res. Treat.41, 15–19 (1996) ArticleCAS Google Scholar
Carpenter, A. E. et al. CellProfiler: image analysis software for identifying and quantifying cell phenotypes. Genome Biol.7, R100 (2006) Article Google Scholar
Lamprecht, M. R., Sabatini, D. M. & Carpenter, A. E. CellProfiler: free, versatile software for automated biological image analysis. Biotechniques42, 71–75 (2007) ArticleCAS Google Scholar