Tbx18 and the fate of epicardial progenitors (original) (raw)

Nature volume 458, pages E8–E9 (2009)Cite this article

Abstract

Arising from: C.-L. Cai et al. Nature 454, 104–108 (2008)10.1038/nature06969; Cai et al. reply

Uncovering the origins of myocardial cells is important for understanding and treating heart diseases1,2. Cai et al.3 suggest that _Tbx18_-expressing epicardium provides a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Here we show that the T-box transcription factor gene 18 (Tbx18) itself is expressed in the myocardium, showing that their genetic lineage tracing system does not allow conclusions of an epicardial origin of cardiomyocytes in vivo to be drawn.

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Authors and Affiliations

  1. * Department of Anatomy & Embryology, Heart Failure Research Center, Academic Medical Center, University of Amsterdam, Meibergdreef 15 L2-108, 1105 AZ Amsterdam, The Netherlands,
    Vincent M. Christoffels & Mathilda T. M. Mommersteeg
  2. † Institut für Molekularbiologie, OE5250, Medizinische Hochschule Hannover, Carl-Neuberg-Str. 1, 30625 Hannover, Germany. kispert.andreas@mh-hannover.de ,
    Thomas Grieskamp, Julia Norden, Carsten Rudat & Andreas Kispert

Authors

  1. Vincent M. Christoffels
  2. Thomas Grieskamp
  3. Julia Norden
  4. Mathilda T. M. Mommersteeg
  5. Carsten Rudat
  6. Andreas Kispert

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Christoffels, V., Grieskamp, T., Norden, J. et al. Tbx18 and the fate of epicardial progenitors.Nature 458, E8–E9 (2009). https://doi.org/10.1038/nature07916

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