A parallel circuit of LIF signalling pathways maintains pluripotency of mouse ES cells (original) (raw)
Niwa, H., Burdon, T., Chambers, I. & Smith, A. Self-renewal of pluripotent embryonic stem cells is mediated via activation of STAT3. Genes Dev.12, 2048–2060 (1998) ArticleCAS Google Scholar
Matsuda, T. et al. STAT3 activation is sufficient to maintain an undifferentiated state of mouse embryonic stem cells. EMBO J.18, 4261–4269 (1999) ArticleCAS Google Scholar
Niwa, H. How is pluripotency determined and maintained? Development134, 635–646 (2007) ArticleCAS Google Scholar
Jaenisch, R. & Young, R. Stem cells, the molecular circuitry of pluripotency and nuclear reprogramming. Cell132, 567–582 (2008) ArticleCAS Google Scholar
Burdon, T., Smith, A. & Savatier, P. Signalling, cell cycle and pluripotency in embryonic stem cells. Trends Cell Biol.12, 432–438 (2002) ArticleCAS Google Scholar
Mitsui, K. et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell113, 631–642 (2003) ArticleCAS Google Scholar
Chambers, I. et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell113, 643–655 (2003) ArticleCAS Google Scholar
Sharov, A. A. et al. Identification of Pou5f1, Sox2, and Nanog downstream target genes with statistical confidence by applying a novel algorithm to time course microarray and genome-wide chromatin immunoprecipitation data. BMC Genomics9, 269 (2008) Article Google Scholar
Toyooka, Y., Shimosato, D., Murakami, K., Takahashi, K. & Niwa, H. Identification and characterization of subpopulations in undifferentiated ES cell culture. Development135, 909–918 (2008) ArticleCAS Google Scholar
Takahashi, K. & Yamanaka, S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell126, 663–676 (2006) ArticleCAS Google Scholar
Li, Y. et al. Murine embryonic stem cell differentiation is promoted by SOCS-3 and inhibited by the zinc finger transcription factor Klf4. Blood105, 635–637 (2005) ArticleCAS Google Scholar
Nakatake, Y. et al. Klf4 cooperates with Oct3/4 and Sox2 to activate the Lefty1 core promoter in embryonic stem cells. Mol. Cell. Biol.26, 7772–7782 (2006) ArticleCAS Google Scholar
Ivanova, N. et al. Dissecting self-renewal in stem cells with RNA interference. Nature442, 533–538 (2006) ArticleADSCAS Google Scholar
Niwa, H., Masui, S., Chambers, I., Smith, A. G. & Miyazaki, J. Phenotypic complementation establishes requirements for specific POU domain and generic transactivation function of Oct-3/4 in embryonic stem cells. Mol. Cell. Biol.22, 1526–1536 (2002) ArticleCAS Google Scholar
Auernhammer, C. J., Bousquet, C. & Melmed, S. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc. Natl Acad. Sci. USA96, 6964–6969 (1999) ArticleADSCAS Google Scholar
Niwa, H., Miyazaki, J. & Smith, A. G. Quantitative expression of Oct-3/4 defines differentiation, dedifferentiation or self-renewal of ES cells. Nature Genet.24, 372–376 (2000) ArticleCAS Google Scholar
Masui, S. et al. Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells. Nature Cell Biol.9, 625–635 (2007) ArticleCAS Google Scholar
Pan, G., Li, J., Zhou, Y., Zheng, H. & Pei, D. A negative feedback loop of transcription factors that controls stem cell pluripotency and self-renewal. FASEB J.20, 1730–1732 (2006) ArticleCAS Google Scholar
Paling, N. R., Wheadon, H., Bone, H. K. & Welham, M. J. Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. J. Biol. Chem.279, 48063–48070 (2004) ArticleCAS Google Scholar
Takahashi, K., Murakami, M. & Yamanaka, S. Role of the phosphoinositide 3-kinase pathway in mouse embryonic stem (ES) cells. Biochem. Soc. Trans.33, 1522–1525 (2005) ArticleCAS Google Scholar
Watanabe, S. et al. Activation of Akt signaling is sufficient to maintain pluripotency in mouse and primate embryonic stem cells. Oncogene25, 2697–2707 (2006) ArticleCAS Google Scholar
Storm, M. P. et al. Regulation of Nanog expression by phosphoinositide 3-kinase-dependent signalling in murine embryonic stem cells. J. Biol. Chem.282, 6265–6273 (2007) ArticleCAS Google Scholar
Ying, Q. L. et al. The ground state of embryonic stem cell self-renewal. Nature453, 519–523 (2008) ArticleADSCAS Google Scholar
Katz, J. P. et al. The zinc-finger transcription factor Klf4 is required for terminal differentiation of goblet cells in the colon. Development129, 2619–2628 (2002) CASPubMedPubMed Central Google Scholar
Davenport, T. G., Jerome-Majewska, L. A. & Papaioannou, V. E. Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome. Development130, 2263–2273 (2003) ArticleCAS Google Scholar
Chambers, I. et al. Nanog safeguards pluripotency and mediates germline development. Nature450, 1230–1234 (2007) ArticleADSCAS Google Scholar
Ema, M. et al. Kruppel-like factor 5 is essential for blastocyst development and the normal self-renewal of mouse ESCs. Cell Stem Cell3, 555–567 (2008) ArticleCAS Google Scholar
Tesar, P. J. et al. New cell lines from mouse epiblast share defining features with human embryonic stem cells. Nature448, 196–199 (2007) ArticleADSCAS Google Scholar
Vallier, L. et al. Activin/Nodal signalling maintains pluripotency by controlling Nanog expression. Development136, 1339–1349 (2009) ArticleCAS Google Scholar
Ogawa, K. et al. Activin-Nodal signaling is involved in propagation of mouse embryonic stem cells. J. Cell Sci.120, 55–65 (2007) ArticleCAS Google Scholar