Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz (original) (raw)

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Data deposits

Newly derived SIVcpz sequences have been deposited in the GenBank database under accession numbers FJ895381–FJ895405.

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Acknowledgements

We thank the field staff at the Gombe Stream Research Centre for collecting behavioural data as well as urine and faecal samples from wild chimpanzees; E. Kaaya for help with necropsies; A. Collins for logistical support; the Tanzania Commission for Science and Technology, the Tanzania Wildlife Research Institute, and the Tanzania National Parks for permission to conduct research in Gombe; I. White for discussions; L. Lowenstine for histological consultation; M. Salazar and Y. Chen for technical assistance; and J. C. White for artwork and manuscript preparation. This work was supported by grants from the National Institutes of Health (R01 AI50529, R01 AI58715, U19 AI067854, T32 GM008111), the National Cancer Institute (contract HHSN266200400088C), the UAB Center for AIDS Research (P30 AI 27767), the Yerkes National Primate Research Center (RR-00165), the National Science Foundation (DBS-9021946, SBR-9319909, BSC-0452315, IIS-0431141, BSC-0648481), the Jane Goodall Institute, the Harris Steel Group, the University of Minnesota, the University of Illinois, the US Fish and Wildlife Service Great Ape Conservation Fund, the Windibrow, Arcus, Guthman and Davee Foundations, and the Lincoln Park Zoo. R.S.R. was funded by a Howard Hughes Medical Institute Med-into-Grad Fellowship. The content of this publication does not necessarily reflect the views or policies of the US Department of Health and Human Services, nor does mention of trade names, commercial products, or organizations imply endorsement by the US Government.

Author Contributions All authors contributed to the acquisition, analysis and interpretation of the data; B.F.K., A.E.P., J.G., G.M.S., P.M.S. and B.H.H. initiated and conceived the study; B.F.K., R.S.R., Y.L. and E.W. performed non-invasive SIVcpz screening and genetic analyses; J.H.J., J.S.-S., M.L.W. and A.E.P. analysed chimpanzee fertility and mortality; K.A.T., M.J.K., J.R., D.A.T. and T.M. performed necropsies; K.A.T. and J.D.E performed immunohistochemistry and in situ hybridization studies; G.H.L. and P.M.S. performed phylogenetic analyses; J.H.J., T.M.B. and P.M.S. performed statistical analyses; M.L.W., A.M., S.K., E.V.L. and D.A.T. conducted and supervised all fieldwork. J.G.E. and G.S. provided data on captive sooty mangabeys; and B.F.K., A.E.P., P.M.S., G.M.S. and B.H.H. coordinated the contributions of all authors and wrote the paper. B.F.K., J.H.J., K.A.T., J.D.E., R.S.R. and M.L.W. contributed equally to this paper.

Author information

Author notes

  1. Brandon F. Keele
    Present address: Present address: The AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702, USA.,

Authors and Affiliations

  1. Department of Medicine,,
    Brandon F. Keele, Yingying Li, Gerald H. Learn, George M. Shaw & Beatrice H. Hahn
  2. Department of Microbiology,,
    Rebecca S. Rudicell & Beatrice H. Hahn
  3. Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA,
    T. Mark Beasley
  4. Department of Anthropology, Stanford University, Stanford, California 94305, USA,
    James Holland Jones
  5. University of Illinois Zoological Pathology Program, Maywood, Illinois 60153, USA ,
    Karen A. Terio & Michael J. Kinsel
  6. The AIDS and Cancer Virus Program, Science Applications International Corporation-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland 21702, USA ,
    Jacob D. Estes
  7. Department of Anthropology, University of Minnesota, Minneapolis, Minnesota 55455, USA,
    Michael L. Wilson
  8. Department of Ecology, Jane Goodall Institute’s Center for Primate Studies, Evolution and Behavior, University of Minnesota, St Paul, Minnesota 55108, USA,
    Michael L. Wilson, Joann Schumacher-Stankey, Emily Wroblewski & Anne E. Pusey
  9. Gombe Stream Research Centre, The Jane Goodall Institute, Kigoma, Tanzania
    Anna Mosser, Jane Raphael & Shadrack Kamenya
  10. The Lester E. Fisher Center for the Study and Conservation of Apes and,,
    Elizabeth V. Lonsdorf
  11. Department of Conservation and Science, Lincoln Park Zoo, Chicago, Illinois 60614, USA,
    Dominic A. Travis
  12. Tanzania National Parks, Arusha, Tanzania
    Titus Mlengeya
  13. Division of Animal Resources, Yerkes National Primate Research Center, Emory University, Atlanta, Georgia 30322, USA,
    James G. Else
  14. Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19107, USA,
    Guido Silvestri
  15. The Jane Goodall Institute, Arlington, Virginia 22203, USA ,
    Jane Goodall
  16. Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3JT, UK
    Paul M. Sharp

Authors

  1. Brandon F. Keele
  2. James Holland Jones
  3. Karen A. Terio
  4. Jacob D. Estes
  5. Rebecca S. Rudicell
  6. Michael L. Wilson
  7. Yingying Li
  8. Gerald H. Learn
  9. T. Mark Beasley
  10. Joann Schumacher-Stankey
  11. Emily Wroblewski
  12. Anna Mosser
  13. Jane Raphael
  14. Shadrack Kamenya
  15. Elizabeth V. Lonsdorf
  16. Dominic A. Travis
  17. Titus Mlengeya
  18. Michael J. Kinsel
  19. James G. Else
  20. Guido Silvestri
  21. Jane Goodall
  22. Paul M. Sharp
  23. George M. Shaw
  24. Anne E. Pusey
  25. Beatrice H. Hahn

Corresponding author

Correspondence toBeatrice H. Hahn.

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Keele, B., Jones, J., Terio, K. et al. Increased mortality and AIDS-like immunopathology in wild chimpanzees infected with SIVcpz.Nature 460, 515–519 (2009). https://doi.org/10.1038/nature08200

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