Effector T cell interactions with meningeal vascular structures in nascent autoimmune CNS lesions (original) (raw)
Wekerle, H., Linington, C., Lassmann, H. & Meyermann, R. Cellular immune reactivity within the CNS. Trends Neurosci.9, 271–277 (1986) Article Google Scholar
Ben-Nun, A., Wekerle, H. & Cohen, I. R. The rapid isolation of clonable antigen-specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis. Eur. J. Immunol.11, 195–199 (1981) ArticleCAS Google Scholar
Flügel, A., Willem, M., Berkowicz, T. & Wekerle, H. Gene transfer into CD4+ T lymphocytes: Green fluorescent protein engineered, encephalitogenic T cells used to illuminate immune responses in the brain. Nature Med.5, 843–847 (1999) Article Google Scholar
Odoardi, F., Kawakami, N., Klinkert, W. E. F., Wekerle, H. & Flügel, A. Blood-borne soluble protein antigen intensifies T cell activation in autoimmune CNS lesions and exacerbates clinical disease. Proc. Natl Acad. Sci. USA104, 18625–18630 (2007) ArticleADSCAS Google Scholar
Traugott, U. & Raine, C. S. Acute experimental allergic encephalomyelitis. Myelin basic protein-reactive T cells in the circulation and in meningeal infiltrates. J. Neurol. Sci.42, 331–336 (1979) ArticleCAS Google Scholar
Tsuchida, M. et al. Identification of CD4-CD8- αβ T cells in the subarachnoid space of rats with experimental autoimmune encephalomyelitis. A possible route by which effector cells invade the lesions. Immunology81, 420–427 (1994) CASPubMedPubMed Central Google Scholar
Auffray, C. et al. Monitoring of blood vessels and tissues by a population of monocytes with patrolling behavior. Science317, 666–670 (2007) ArticleADSCAS Google Scholar
Phillipson, M. et al. Intraluminal crawling of neutrophils to emigration sites: a molecularly distinct process from adhesion in the recruitment cascade. J. Exp. Med.203, 2569–2575 (2006) ArticleCAS Google Scholar
Geissmann, F. et al. Intravascular immune surveillance by CXCR6+ NKT cells patrolling liver sinusoids. PLoS Biol.3, e113 (2005) Article Google Scholar
Flügel, A. et al. Migratory activity and functional changes of green fluorescent effector T cells before and during experimental autoimmune encephalomyelitis. Immunity14, 547–560 (2001) Article Google Scholar
Vajkoczy, P., Laschinger, M. & Engelhardt, B. α4-integrin-VCAM binding mediates G protein independent capture of encephalitogenic T cell blasts to CNS white matter microvessels. J. Clin. Invest.108, 557–565 (2001) ArticleCAS Google Scholar
Kawakami, N. et al. Autoimmune CD4+ T cell memory: Lifelong persistence of encephalitogenic T cell clones in healthy immune repertoires. J. Immunol.175, 69–81 (2005) ArticleCAS Google Scholar
Wolf, K. et al. Compensation mechanism in tumor cell migration: mesenchymal–amoeboid transition after blocking of pericellular proteolysis. J. Cell Biol.160, 267–277 (2003) ArticleCAS Google Scholar
Yednock, T. A. et al. Prevention of experimental autoimmune encephalomyelitis by antibodies against α4β1 integrin. Nature356, 63–66 (1992) ArticleADSCAS Google Scholar
Schenkel, A. R., Mamdouh, Z. & Muller, W. A. Locomotion of monocytes on endothelium is a critical step during extravasation. Nature Immunol.5, 393–400 (2004) ArticleCAS Google Scholar
Carman, C. V. et al. Transcellular diapedesis is initiated by invasive podosomes. Immunity26, 784–797 (2007) ArticleCAS Google Scholar
Walther, M. et al. Exogenous antigen containing perivascular phagocytes induce a non-encephalitogenic extravasation of primed lymphocytes. J. Neuroimmunol.117, 30–42 (2001) ArticleCAS Google Scholar
Hickey, W. F., Vass, K. & Lassmann, H. Bone marrow derived elements in the central nervous system: an immunohistochemical and ultrastructural survey of rat chimeras. J. Neuropathol. Exp. Neurol.51, 246–256 (1992) ArticleCAS Google Scholar
Matyszak, M. K. & Perry, V. H. The potential role of dendritic cells in immune-mediated inflammatory diseases in the central nervous system. Neuroscience74, 599–608 (1996) ArticleCAS Google Scholar
McMenamin, P. G., Wealthall, R. J., Deverall, M., Cooper, S. J. & Griffin, B. Macrophages and dendritic cells in the rat meninges and choroid plexus: three-dimensional localisation by environmental scanning electron microscopy and confocal microscopy. Cell Tissue Res.313, 259–269 (2003) Article Google Scholar
Kivisäkk, P. et al. Localizing central nervous system immune surveillance: Meningeal antigen-presenting cells activate T cells during experimental autoimmune encephalomyelitis. Ann. Neurol.65, 457–469 (2009) Article Google Scholar
Reboldi, A. et al. C-C chemokine receptor 6–regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE. Nature Immunol.10, 514–523 (2009) ArticleCAS Google Scholar
Becher, B., Bechmann, I. & Greter, M. Antigen presentation in autoimmunity and CNS inflammation: how T lymphocytes recognize the brain. J. Mol. Med.84, 532–543 (2006) ArticleCAS Google Scholar
Bechmann, I., Galea, I. & Perry, V. H. What is the blood-brain barrier (not)? Trends Immunol.28, 5–11 (2007) ArticleCAS Google Scholar
Hinrichs, D. J., Wegmann, K. W. & Dietsch, G. N. Transfer of experimental allergic encephalomyelitis to bone marrow chimeras: endothelial cells are not the restricting element. J. Exp. Med.166, 1906–1911 (1987) ArticleCAS Google Scholar
Hickey, W. F. & Kimura, H. Perivascular microglial cells of the CNS are bone-marrow derived and present antigen in vivo . Science239, 290–292 (1988) ArticleADSCAS Google Scholar
Lois, C., Hong, I. J., Pease, S., Brown, E. J. & Baltimore, D. Germline transmission and tissue-specific expression of transgenes delivered by lentiviral vectors. Science295, 868–872 (2002) ArticleADSCAS Google Scholar
Kawakami, N. et al. Live imaging of effector cell trafficking and autoantigen recognition within the unfolding autoimmune encephalomyelitis lesion. J. Exp. Med.201, 1805–1814 (2005) ArticleCAS Google Scholar
Kawakami, N. et al. The activation status of neuroantigen-specific T cells in the target organ determines the clinical outcome of autoimmune encephalomyelitis. J. Exp. Med.199, 185–197 (2004) ArticleCAS Google Scholar
Hadjantonakis, A.-K., Gertsenstein, M., Ikawa, M., Okabe, M. & Nagy, A. Generating green fluorescent mice by germline transmission of green fluorescent ES cells. Mech. Dev.76, 79–90 (1998) ArticleCAS Google Scholar
Eylar, E. H., Kniskern, P. J. & Jackson, J. J. Myelin basic proteins. Methods Enzymol.32, 323–341 (1974) ArticleCAS Google Scholar
Odoardi, F. et al. Instant effect of soluble antigen on effector T cells in peripheral immune organs during immunotherapy of autoimmune encephalomyelitis. Proc. Natl Acad. Sci. USA104, 920–925 (2007) ArticleADSCAS Google Scholar
Kuchroo, V. K. et al. Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor Vβ usage. J. Immunol.148, 3776–3782 (1992) CASPubMed Google Scholar
Tamatani, T., Kotani, M. & Miyasaka, M. Characterization of the rat leukocyte integrin, CD11/CD18, by the use of LFA-1 subunit specific monoclonal antibodies. Eur. J. Immunol.21, 627–633 (1991) ArticleCAS Google Scholar
Issekutz, T. B. Dual inhibition of VLA-4 and LFA-1 maximally inhibits cutaneous delayed-type hypersensitivity-induced inflammation. Am. J. Pathol.143, 1286–1293 (1993) CASPubMedPubMed Central Google Scholar
Kornack, D. R. & Rakic, P. Changes in cell-cycle kinetics during the development and evolution of primate neocortex. Proc. Natl Acad. Sci. USA95, 1242–1246 (1998) ArticleADSCAS Google Scholar