Complex landscapes of somatic rearrangement in human breast cancer genomes (original) (raw)

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Acknowledgements

We are grateful to M. Lambros, F. Geyer and R. Vatcheva for their assistance in the FISH experiments. We would like to acknowledge the support of the Kay Kendall Leukaemia Fund under Grant KKL282, Human Frontiers Award reference LT000561/2009-L, the Dana-Farber/Harvard SPORE in breast cancer under NCI grant reference CA089393, Breakthrough Breast Cancer, the Research Council of Norway Grants no. 155218 and 175240, and the Wellcome Trust under grant reference 077012/Z/05/Z.

Author Contributions M.R.S., P.A.F., P.J.C. and P.J.S. designed the experiment. S.E., D.J.M., P.J.S., M-L.L., I.V., L.J.M., J.B., M.A.Q., H.S., C.C., R.N., A.M.S., A.L., J.W.M.M. and C.Latimer carried out laboratory analyses. J.A.F., J.S.R.-F., L.v.V., A.L.R. D.P.S. and A.-L.B.-D. provided clinical samples. P.J.S., D.J.M., I.V., M.-L.L., E.D.P., J.T.S., L.A.S., C.Leroy, C.D.G., M.J., J.W.T., K.W.L., P.J.C., P.A.F., J.S.R.-F., J.W.M.M., A.M.S., J.A.F., M.R.S., H.E.G.R., A.L.R., A.-L.B.-D., L.v.V., A.L., P.J.C. and P.A.F. performed data analysis, informatics and statistics. M.R.S. wrote the manuscript with comments from P.J.S., P.A.F., P.J.C., A.-L.B.-D., J.S.R.-F., J.A.F., A.L.R., D.P.S. and L.v.V.

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Authors and Affiliations

1. Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK ,
   Philip J. Stephens, David J. McBride, Meng-Lay Lin, Ignacio Varela, Erin D. Pleasance, Jared T. Simpson, Lucy A. Stebbings, Catherine Leroy, Sarah Edkins, Laura J. Mudie, Chris D. Greenman, Mingming Jia, Calli Latimer, Jon W. Teague, King Wai Lau, John Burton, Michael A. Quail, Harold Swerdlow, Carol Churcher, Peter J. Campbell, P. Andrew Futreal & Michael R. Stratton
2. Molecular Pathology Laboratory, The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, 237 Fulham Road, London SW3 6JB, UK ,
   Rachael Natrajan & Jorge S. Reis-Filho
3. Department of Medical Oncology, Josephine Nefkens Institute, Erasmus University Medical Center, PO Box 2040, 3000 CA, Rotterdam, The Netherlands,
   Anieta M. Sieuwerts, John W. M. Martens & John A. Foekens
4. Department of Cancer Biology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA,
   Daniel P. Silver & Andrea L. Richardson
5. Department of Genetics, Norwegian Radium Hospital, Oslo University Hospital, Montebello, N-0310 Oslo, Norway,
   Anita Langerød, Hege E. G. Russnes & Anne-Lise Børresen-Dale
6. The Netherlands Cancer Institute, 121 Plesmanlaan, 1066 CX Amsterdam, The Netherlands ,
   Laura van ’t Veer
7. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA,
   Andrea L. Richardson
8. Department of Genetics, Institute for Cancer Research, Oslo University Hospital Radiumhospitalet, Montebello, 0310 Oslo, Norway,
   Anne-Lise Børresen-Dale
9. Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK. ,
   Michael R. Stratton

Authors

1. Philip J. Stephens
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2. David J. McBride
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3. Meng-Lay Lin
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4. Ignacio Varela
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5. Erin D. Pleasance
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6. Jared T. Simpson
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7. Lucy A. Stebbings
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8. Catherine Leroy
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9. Sarah Edkins
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10. Laura J. Mudie
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11. Chris D. Greenman
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12. Mingming Jia
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13. Calli Latimer
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14. Jon W. Teague
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15. King Wai Lau
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16. John Burton
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17. Michael A. Quail
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18. Harold Swerdlow
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19. Carol Churcher
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20. Rachael Natrajan
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21. Anieta M. Sieuwerts
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22. John W. M. Martens
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23. Daniel P. Silver
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24. Anita Langerød
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25. Hege E. G. Russnes
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26. John A. Foekens
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27. Jorge S. Reis-Filho
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28. Laura van ’t Veer
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29. Andrea L. Richardson
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30. Anne-Lise Børresen-Dale
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31. Peter J. Campbell
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32. P. Andrew Futreal
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33. Michael R. Stratton
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Corresponding authors

Correspondence toP. Andrew Futreal or Michael R. Stratton.

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The authors declare no competing financial interests.

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Stephens, P., McBride, D., Lin, ML. et al. Complex landscapes of somatic rearrangement in human breast cancer genomes.Nature 462, 1005–1010 (2009). https://doi.org/10.1038/nature08645

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• Received: 20 July 2009
• Accepted: 05 November 2009
• Issue Date: 24 December 2009
• DOI: https://doi.org/10.1038/nature08645