Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes (original) (raw)

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Primary accessions

ArrayExpress

Gene Expression Omnibus

Data deposits

The patient and cell line expression data were deposited with the Gene Expression Omnibus and Array Express under accession numbers GSE17895 and E-TABM-770, respectively.

References

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Acknowledgements

We would like to acknowledge the Wellcome Trust for support under grant reference 077012/Z/05/Z and the Hauenstein and Gerber Foundations for support for the microarray expression work. We also thank S. Martin, W. McLaughlin and S. Noyes for administrative support and F. Brasseur for providing the matched-pair ccRCC cell lines.

Author Contributions G.L.D. directed the analytical aspects of the study. K.F., K.J.D. and L.C. performed the expression analyses. C.G. contributed statistical analyses. G.B., H.D., S.E., C.H., J.T., A.B., Je.A., S.B., D.B., G.B., P.J.C., S.F., M.J., D.J., H.K., C.Y.K., C.L., M.-L.L., D.J.M., M.M., S.M., K.M., A.M., T.M., Le.M., La.M., S.O., E.P., A.R., Re.S., Ra.S., L.S., P.S., G.T., P.S.T. and K.T. performed the sequencing, copy number, data analyses and provided comments on the manuscript. Jo.A., R.J.K., S.K.K., D.P., B.W. and B.T.T. contributed samples, data and comments on the manuscript. M.R.S. and P.A.F. conceived and directed the study and wrote the manuscript.

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Authors and Affiliations

1. Cancer Genome Project, Wellcome Trust Sanger Institute, Hinxton CB10 1SA, UK
   Gillian L. Dalgliesh, Chris Greenman, Lina Chen, Graham Bignell, Adam Butler, Helen Davies, Sarah Edkins, Claire Hardy, Calli Latimer, Jon Teague, Jenny Andrews, Syd Barthorpe, Dave Beare, Gemma Buck, Peter J. Campbell, Simon Forbes, Mingming Jia, David Jones, Henry Knott, Chai Yin Kok, King Wai Lau, Catherine Leroy, Meng-Lay Lin, David J. McBride, Mark Maddison, Simon Maguire, Kirsten McLay, Andrew Menzies, Tatiana Mironenko, Lee Mulderrig, Laura Mudie, Sarah O’Meara, Erin Pleasance, Arjunan Rajasingham, Rebecca Shepherd, Raffaella Smith, Lucy Stebbings, Philip Stephens, Gurpreet Tang, Patrick S. Tarpey, Kelly Turrell, Michael R. Stratton & P. Andrew Futreal
2. Laboratory of Computational Biology,,
   Kyle Furge, Karl J. Dykema & Bill Wondergem
3. Laboratory of Cancer Genertics, Van Andel Research Institute, Grand Rapids, Michigan 49503, USA ,
   Sok Kean Khoo, David Petillo & Bin Tean Teh
4. Department of Urology, Spectrum Health Hospital, Grand Rapids, Michigan 49503, USA,
   John Anema & Richard J. Kahnoski
5. NCCS-VARI Translational Cancer Research Laboratory, National Cancer Centre, 169610, Singapore
   Bin Tean Teh
6. Institute of Cancer Research, Sutton, Surrey SM2 5NG, UK ,
   Michael R. Stratton

Authors

1. Gillian L. Dalgliesh
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2. Kyle Furge
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3. Chris Greenman
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4. Lina Chen
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5. Graham Bignell
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6. Adam Butler
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7. Helen Davies
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8. Sarah Edkins
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9. Claire Hardy
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10. Calli Latimer
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11. Jon Teague
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12. Jenny Andrews
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13. Syd Barthorpe
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14. Dave Beare
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15. Gemma Buck
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16. Peter J. Campbell
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17. Simon Forbes
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18. Mingming Jia
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19. David Jones
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20. Henry Knott
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21. Chai Yin Kok
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22. King Wai Lau
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23. Catherine Leroy
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24. Meng-Lay Lin
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25. David J. McBride
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26. Mark Maddison
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27. Simon Maguire
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28. Kirsten McLay
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29. Andrew Menzies
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30. Tatiana Mironenko
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31. Lee Mulderrig
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32. Laura Mudie
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33. Sarah O’Meara
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34. Erin Pleasance
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35. Arjunan Rajasingham
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36. Rebecca Shepherd
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37. Raffaella Smith
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38. Lucy Stebbings
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39. Philip Stephens
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40. Gurpreet Tang
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41. Patrick S. Tarpey
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42. Kelly Turrell
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43. Karl J. Dykema
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44. Sok Kean Khoo
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45. David Petillo
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46. Bill Wondergem
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47. John Anema
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48. Richard J. Kahnoski
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49. Bin Tean Teh
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50. Michael R. Stratton
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51. P. Andrew Futreal
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Corresponding authors

Correspondence toBin Tean Teh, Michael R. Stratton or P. Andrew Futreal.

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Dalgliesh, G., Furge, K., Greenman, C. et al. Systematic sequencing of renal carcinoma reveals inactivation of histone modifying genes.Nature 463, 360–363 (2010). https://doi.org/10.1038/nature08672

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• Received: 20 July 2009
• Accepted: 11 November 2009
• Published: 06 January 2010
• Issue Date: 21 January 2010
• DOI: https://doi.org/10.1038/nature08672