Regulation of myeloid leukaemia by the cell-fate determinant Musashi (original) (raw)

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Acknowledgements

We thank A. M. Pendergast, J. Chute, K. Itahana, L. Penalva and L. Grimes for advice and reagents; K.-i. Yamamura for the Msi2 gene-trap mice; T. Honjo for the Rbpj conditional mice; N. Gaiano for the TNR mice; D. Baltimore for the lentiviral shRNA constructs; and A. Means and B. Hogan for comments on the manuscript. We also thank M. Cook, B. Harvat and L. Martinek for cell sorting; M. Fereshteh for advice on analysis of patient samples; D. McDonnell and H. Wade for advice on ChIP experiments; S. W. Tian for help in collecting patient samples and A. Chen and S. Honeycutt for technical help. The BCR–ABL construct was a gift from W. Pear and the NUP98–HOXA9 construct a gift from G. Gilliland. T.I. is the recipient of a postdoctoral fellowship from the Astellas Foundation for Research on Metabolic Disorders, K.L.C. is the recipient of an American Heart Association predoctoral award, B.Z. received support from T32 GM007184-33 and T.R. is the recipient of a Leukemia and Lymphoma Society Scholar Award. This work was also supported by an LLS Translational Research grant and an ASH Junior Faculty Award to V.G.O., as well as NIH grants CA18029 to J.P.R., CA140371 to V.G.O., CA122206 to C.T.J. and DK63031, DK072234, AI067798, HL097767, DP1OD006430 and an Alexander and Margaret Stewart Fund grant to T.R. We are grateful for the support received from the Lisa Stafford Research Prize.

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Author notes

1. Takahiro Ito and Hyog Young Kwon: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, 27710, North Carolina, USA
   Takahiro Ito, Hyog Young Kwon, Bryan Zimdahl, Kendra L. Congdon, Jordan Blum, William E. Lento, Chen Zhao & Tannishtha Reya
2. Department of Pathology, Duke University Medical Center, Durham, 27710, North Carolina, USA
   Anand Lagoo
3. Department of Haematology, Imperial College London, Hammersmith Hospital, London, W12 0NN, UK
   Gareth Gerrard, Letizia Foroni & John Goldman
4. Division of Hematology, Seoul St Mary’s Hospital, The Catholic University of Korea, Seoul, Korea
   Harriet Goh, Soo-Hyun Kim & Dong-Wook Kim
5. Department of Haematology, Singapore General Hospital, Cancer and Stem Cell Biology Program, Duke-NUS Graduate Medical School, Singapore
   Charles Chuah
6. Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, 98109, Washington, USA
   Vivian G. Oehler & Jerald P. Radich
7. James P. Wilmot Cancer Center, University of Rochester School of Medicine, Rochester, 14642, New York, USA
   Craig T. Jordan

Authors

1. Takahiro Ito
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2. Hyog Young Kwon
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3. Bryan Zimdahl
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4. Kendra L. Congdon
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5. Jordan Blum
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6. William E. Lento
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7. Chen Zhao
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8. Anand Lagoo
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9. Gareth Gerrard
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10. Letizia Foroni
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11. John Goldman
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12. Harriet Goh
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13. Soo-Hyun Kim
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14. Dong-Wook Kim
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15. Charles Chuah
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16. Vivian G. Oehler
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17. Jerald P. Radich
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18. Craig T. Jordan
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19. Tannishtha Reya
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Contributions

T.I. and H.Y.K. designed the research, performed the majority of the experiments and helped write the paper. B.Z., K.L.C., J.B., W.E.L. and C.Z. provided experimental data and help; A.L. provided histopathological analysis; C.T.J., G.G., L.F., J.G., H.G., S.-H.K., D.-W.K. and C.C. provided human patient samples and experimental advice; T.I., H.Y.K., G.G. and B.Z. defined gene expression in patient samples by PCR; and V.G.O. and J.P.R. carried out all microarray and patient outcome analyses. T.R. conceived of the project, planned and guided the research, and wrote the paper.

Corresponding author

Correspondence toTannishtha Reya.

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Competing interests

T.I., H.Y.K., D.W.K., V.O., J.P.R. and T.R. are named inventors on a provisional patent application no. 61/178,370 titled ‘Diagnostic and treatment for chronic and acute myeloid leukemia’.

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Ito, T., Kwon, H., Zimdahl, B. et al. Regulation of myeloid leukaemia by the cell-fate determinant Musashi.Nature 466, 765–768 (2010). https://doi.org/10.1038/nature09171

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• Received: 07 August 2008
• Accepted: 13 May 2010
• Published: 18 July 2010
• Issue Date: 05 August 2010
• DOI: https://doi.org/10.1038/nature09171