Caspase signalling controls microglia activation and neurotoxicity (original) (raw)

• Hanisch, U. K. & Kettenmann, H. Microglia: active sensor and versatile effector cells in the normal and pathologic brain. Nature Neurosci. 10, 1387–1394 (2007)
  Article CAS Google Scholar
• Block, M. L., Zecca, L. & Hong, J. S. Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nature Rev. Neurosci. 8, 57–69 (2007)
  Article CAS Google Scholar
• Chao, C. C., Hu, S., Molitor, T. W., Shaskan, E. G. & Peterson, P. K. Activated microglia mediate neuronal cell injury via a nitric oxide mechanism. J. Immunol. 149, 2736–2741 (1992)
  CAS PubMed Google Scholar
• Castano, A., Herrera, A. J., Cano, J. & Machado, A. Lipopolysaccharide intranigral injection induces inflammatory reaction and damage in nigrostriatal dopaminergic system. J. Neurochem. 70, 1584–1592 (1998)
  Article CAS Google Scholar
• Saijo, K. et al. A Nurr1/CoREST pathway in microglia and astrocytes protects dopaminergic neurons from inflammation-induced death. Cell 137, 47–59 (2009)
  Article CAS Google Scholar
• Zhao, J. et al. IRF-8/interferon (IFN) consensus sequence-binding protein is involved in Toll-like receptor (TLR) signaling and contributes to the cross-talk between TLR and IFN-gamma signaling pathways. J. Biol. Chem. 281, 10073–10080 (2006)
  Article CAS Google Scholar
• Car, B. D. et al. Interferon gamma receptor deficient mice are resistant to endotoxic shock. J. Exp. Med. 179, 1437–1444 (1994)
  Article CAS Google Scholar
• Jin, J. J., Kim, H. D., Maxwell, J. A., Li, L. & Fukuchi, K. Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer’s disease. J. Neuroinflammation 5, 23 (2008)
  Article Google Scholar
• Balistreri, C. R. et al. Association between the polymorphisms of TLR4 and CD14 genes and Alzheimer’s disease. Curr. Pharm. Des. 14, 2672–2677 (2008)
  Article CAS Google Scholar
• Walter, S. et al. Role of the toll-like receptor 4 in neuroinflammation in Alzheimer’s disease. Cell. Physiol. Biochem. 20, 947–956 (2007)
  Article CAS Google Scholar
• Nicholson, D. W. et al. Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis. Nature 376, 37–43 (1995)
  Article ADS CAS Google Scholar
• Cohen, G. M. Caspases: the executioners of apoptosis. Biochem. J. 326, 1–16 (1997)
  Article CAS Google Scholar
• Keller, M., Ruegg, A., Werner, S. & Beer, H. D. Active caspase-1 is a regulator of unconventional protein secretion. Cell 132, 818–831 (2008)
  Article CAS Google Scholar
• Schulz, J. B. et al. Extended therapeutic window for caspase inhibition and synergy with MK-801 in the treatment of cerebral histotoxic hypoxia. Cell Death Differ. 5, 847–857 (1998)
  Article ADS CAS Google Scholar
• Braun, J. S. et al. Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nature Med. 5, 298–302 (1999)
  Article CAS Google Scholar
• Cutillas, B., Espejo, M., Gil, J., Ferrer, I. & Ambrosio, S. Caspase inhibition protects nigral neurons against 6-OHDA-induced retrograde degeneration. Neuroreport 10, 2605–2608 (1999)
  Article CAS Google Scholar
• Depino, A. M. et al. Microglial activation with atypical proinflammatory cytokine expression in a rat model of Parkinson’s disease. Eur. J. Neurosci. 18, 2731–2742 (2003)
  Article Google Scholar
• Kawai, T. & Akira, S. Signaling to NF-κB by Toll-like receptors. Trends Mol. Med. 13, 460–469 (2007)
  Article CAS Google Scholar
• Gibbons, H. M. & Dragunow, M. Microglia induce neural cell death via a proximity-dependent mechanism involving nitric oxide. Brain Res. 1084, 1–15 (2006)
  Article CAS Google Scholar
• Schumann, R. R. et al. Lipopolysaccharide activates caspase-1 (interleukin-1-converting enzyme) in cultured monocytic and endothelial cells. Blood 91, 577–584 (1998)
  CAS Google Scholar
• Li, P. et al. Mice deficient in IL-1β-converting enzyme are defective in production of mature IL-1β and resistant to endotoxic shock. Cell 80, 401–411 (1995)
  Article CAS Google Scholar
• Friedlander, R. M. et al. Expression of a dominant negative mutant of interleukin-1β converting enzyme in transgenic mice prevents neuronal cell death induced by trophic factor withdrawal and ischemic brain injury. J. Exp. Med. 185, 933–940 (1997)
  Article CAS Google Scholar
• Fernandes-Alnemri, T. et al. In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains. Proc. Natl Acad. Sci. USA 93, 7464–7469 (1996)
  Article ADS CAS Google Scholar
• Nunez, G., Benedict, M. A., Hu, Y. & Inohara, N. Caspases: the proteases of the apoptotic pathway. Oncogene 17, 3237–3245 (1998)
  Article Google Scholar
• Slee, E. A., Adrain, C. & Martin, S. J. Serial killers: ordering caspase activation events in apoptosis. Cell Death Differ. 6, 1067–1074 (1999)
  Article CAS Google Scholar
• Aliprantis, A. O., Yang, R. B., Weiss, D. S., Godowski, P. & Zychlinsky, A. The apoptotic signaling pathway activated by Toll-like receptor-2. EMBO J. 19, 3325–3336 (2000)
  Article CAS Google Scholar
• Jung, D. Y. et al. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J. Immunol. 174, 6467–6476 (2005)
  Article CAS Google Scholar
• Kuno, R. et al. Autocrine activation of microglia by tumor necrosis factor-alpha. J. Neuroimmunol. 162, 89–96 (2005)
  Article CAS Google Scholar
• Storz, P., Doppler, H. & Toker, A. Protein kinase Cdelta selectively regulates protein kinase D-dependent activation of NF-κB in oxidative stress signaling. Mol. Cell. Biol. 24, 2614–2626 (2004)
  Article CAS Google Scholar
• Vancurova, I., Miskolci, V. & Davidson, D. NF-κB activation in tumor necrosis factor α-stimulated neutrophils is mediated by protein kinase Cδ. Correlation to nuclear IκBα. J. Biol. Chem. 276, 19746–19752 (2001)
  Article CAS Google Scholar
• Reyland, M. E., Anderson, S. M., Matassa, A. A., Barzen, K. A. & Quissell, D. O. Protein kinase Cδ is essential for etoposide-induced apoptosis in salivary gland acinar cells. J. Biol. Chem. 274, 19115–19123 (1999)
  Article CAS Google Scholar
• Czlonkowska, A., Kohutnicka, M., Kurkowska-Jastrzebska, I. & Czlonkowski, A. Microglial reaction in MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) induced Parkinson’s disease mice model. Neurodegeneration 5, 137–143 (1996)
  Article CAS Google Scholar
• Aarli, J. A. Role of cytokines in neurological disorders. Curr. Med. Chem. 10, 1931–1937 (2003)
  Article CAS Google Scholar
• Gonzalez-Scarano, F. & Baltuch, G. Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 22, 219–240 (1999)
  Article CAS Google Scholar
• Jordan, J., Segura, T., Brea, D., Galindo, M. F. & Castillo, J. Inflammation as therapeutic objective in stroke. Curr. Pharm. Des. 14, 3549–3564 (2008)
  Article CAS Google Scholar
• Lenzlinger, P. M., Morganti-Kossmann, M. C., Laurer, H. L. & McIntosh, T. K. The duality of the inflammatory response to traumatic brain injury. Mol. Neurobiol. 24, 169–181 (2001)
  Article CAS Google Scholar
• Allan, S. M. & Rothwell, N. J. Inflammation in central nervous system injury. Phil. Trans. R. Soc. Lond. B 358, 1669–1677 (2003)
  Article CAS Google Scholar
• Karatas, H. et al. A nanomedicine transports a peptide caspase-3 inhibitor across the blood-brain barrier and provides neuroprotection. J. Neurosci. 29, 13761–13769 (2009)
  Article CAS Google Scholar
• Bilsland, J. & Harper, S. Caspases and neuroprotection. Curr. Opin. Investig. Drugs 3, 1745–1752 (2002)
  CAS PubMed Google Scholar
• Friedlander, R. M. Apoptosis and caspases in neurodegenerative diseases. N. Engl. J. Med. 348, 1365–1375 (2003)
  Article CAS Google Scholar
• Le, D. A. et al. Caspase activation and neuroprotection in caspase-3-deficient mice after in vivo cerebral ischemia and in vitro oxygen glucose deprivation. Proc. Natl Acad. Sci. USA 99, 15188–15193 (2002)
  Article ADS CAS Google Scholar
• Joseph, B. et al. p57(Kip2) cooperates with Nurr1 in developing dopamine cells. Proc. Natl Acad. Sci. USA 100, 15619–15624 (2003)
  Article ADS CAS Google Scholar
• Bocchini, V. et al. An immortalized cell line expresses properties of activated microglial cells. J. Neurosci. Res. 31, 616–621 (1992)
  Article CAS Google Scholar
• Giulian, D. & Baker, T. J. Characterization of ameboid microglia isolated from developing mammalian brain. J. Neurosci. 6, 2163–2178 (1986)
  Article CAS Google Scholar
• Li, J. Y. et al. Lewy bodies in grafted neurons in subjects with Parkinson’s disease suggest host-to-graft disease propagation. Nature Med. 14, 501–503 (2008)
  Article ADS CAS Google Scholar
• Joseph, B. et al. Mitochondrial dysfunction is an essential step for killing of non-small cell lung carcinomas resistant to conventional treatment. Oncogene 21, 65–77 (2002)
  Article CAS Google Scholar
• Rite, I., Machado, A., Cano, J. & Venero, J. L. Blood-brain barrier disruption induces in vivo degeneration of nigral dopaminergic neurons. J. Neurochem. 101, 1567–1582 (2007)
  Article CAS Google Scholar