Seventy-five genetic loci influencing the human red blood cell (original) (raw)

Accession codes

Data deposits

Summary statistics from the genome-wide association study are available from the European Genome‐Phenome Archive (EGA, http://www.ebi.ac.uk/ ega) under accession number EGAS00000000132.

Change history

Footnote symbols in the Table 1 legend were corrected.

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Acknowledgements

A detailed list of acknowledgements is provided in the Supplementary Material.

Author information

Author notes

  1. Pim van der Harst, Weihua Zhang, Irene Mateo Leach, Augusto Rendon, Niek Verweij, Joban Sehmi, Dirk S. Paul, Ulrich Elling, Andrew A. Hicks, Josef Martin Penninger, Christian Gieger, Jaspal S. Kooner, Willem H. Ouwehand, Nicole Soranzo and John C. Chambers: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Pim van der Harst, Irene Mateo Leach, Niek Verweij, Rudolf A. de Boer, Herman H. W. Silljé, Wiek H. van Gilst & Dirk J. van Veldhuisen
  2. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Pim van der Harst, Lude Franke & Harm-Jan Westra
  3. Department of Epidemiology and Biostatistics, Imperial College London, London, W2 1PG, UK
    Weihua Zhang, Abtehale Al-Hussani, Paul F. O’Reilly, Paul Elliott, Marjo-Riitta Jarvelin & John C. Chambers
  4. Ealing Hospital NHS Trust, Middlesex, UB1 3HW, UK
    Weihua Zhang, Joban Sehmi, Sian-Tsung Tan, Kathy Miller, Jaspal S. Kooner & John C. Chambers
  5. Department of Haematology, University of Cambridge, Cambridge, CB2 0XY, UK
    Augusto Rendon, Aparna Radhakrishnan, Katrin Voss, Cornelis A. Albers, Antony Attwood, Stephen F. Garner, Jennifer Jolley, Heather Lloyd-Jones, Stuart Meacham, Jennifer Sambrook, Jonathan Stephens & Willem H. Ouwehand
  6. NHS Blood and Transplant, Cambridge, CB2 0PT, UK
    Augusto Rendon, Aparna Radhakrishnan, Katrin Voss, Cornelis A. Albers, Antony Attwood, Stephen F. Garner, Jennifer Jolley, Heather Lloyd-Jones, Stuart Meacham, Jennifer Sambrook, Jonathan Stephens & Willem H. Ouwehand
  7. MRC Biostatistics Unit, Institute of Public Health, Cambridge, CB2 2SR, UK
    Augusto Rendon
  8. NIHR Cambridge Biomedical Research Centre, Cambridge, CB2 0QQ, UK
    Augusto Rendon, Aparna Radhakrishnan, Katrin Voss, Antony Attwood, Stephen F. Garner, Jennifer Jolley, Heather Lloyd-Jones, Stuart Meacham, Jennifer Sambrook, Jonathan Stephens & Willem H. Ouwehand
  9. National Heart and Lung Institute, Imperial College London, London, W12 0NN, UK
    Joban Sehmi, Sian-Tsung Tan, William O. Cookson, Miriam F. Moffatt, James Scott & Jaspal S. Kooner
  10. Wellcome Trust Sanger Institute, Hinxton, Cambridge, CB10 1SA, UK
    Dirk S. Paul, Aparna Radhakrishnan, Cornelis A. Albers, Stavroula Kanoni, So-Youn Shin, Antony Attwood, Stuart Meacham, Yasin Memari, Ramiro Ramirez-Solis, Panos Deloukas, Willem H. Ouwehand & Nicole Soranzo
  11. Institute of Molecular Biotechnology of the Austrian Academy of Sciences, Vienna, 1030, Austria
    Ulrich Elling, Maria Novatchkova, Ursula Puc, Gerald Wirnsberger & Josef Martin Penninger
  12. Department of Preventive Medicine, University of Southern California Keck School of Medicine, Los Angeles, 90033, California, USA
    Hooman Allayee & Jaana Hartiala
  13. Institute of Clinical Sciences, Imperial College London, London, W12 0NN, UK
    Xinzhong Li
  14. NIHR Cardiovascular Biomedical Research Unit, Royal Brompton and Harefield NHS Foundation Trust and Imperial College London, London, SW3 6NP, UK
    Xinzhong Li & John C. Chambers
  15. Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, 39100, Italy
    Christian X. Weichenberger, Martin Gögele, Francisco S. Domingues, Aude Saint-Pierre, Peter P. Pramstaller & Andrew A. Hicks
  16. Department of Cardiology, Division Heart and Lungs, University Medical Center Utrecht, Utrecht, 3508, The Netherlands
    Folkert W. Asselbergs & Vinicius Tragante
  17. Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, 3508, The Netherlands
    Folkert W. Asselbergs, Paul I. W. de Bakker & Ale Algra
  18. Department of Medical Genetics, Biomedical Genetics, University Medical Center Utrecht, Utrecht, 3508, The Netherlands
    Folkert W. Asselbergs & Paul I. W. de Bakker
  19. Institute of Genetics and Biophysics “Adriano Buzzati-Traverso”-CNR, Naples, 80131, Italy
    Marina Ciullo, Evelin Mihailov, Teresa Nutile, Daniela Ruggiero & Rossella Sorice
  20. Dipartimento di Scienze Biomediche e Biotecnologie - Università di Cagliari, Clinica Pediatrica 2a, Ospedale Regionale Microcitemie ASL8, 09121 Cagliari, Italy.,
    Fabrice Danjou, Franco Anni & Renzo Galanello
  21. Institut National de la Santé et de la Recherche Médicale (INSERM) Unité Mixte de Recherche (UMR) 1087, BP 70721 44007 Nantes cedex, 1 Nantes, France.,
    Christian Dina
  22. Centre National de la Recherche Scientifique (CNRS) UMR 6291, BP 70721 44007 Nantes cedex 1, Nantes, France ,
    Christian Dina
  23. School of Medecine, Nantes University, Nantes, 44000, France
    Christian Dina
  24. Estonian Genome Center of University of Tartu, Tartu, 51010, Estonia
    Tõnu Esko, Krista Fischer & Andres Metspalu
  25. Institute of Molecular and Cell Biology, University of Tartu, Tartu, 51010, Estonia
    Tõnu Esko & Andres Metspalu
  26. MRC Centre for Causal Analyses in Translational Epidemiology, School of Social and Community Medicine, University of Bristol, Bristol, BS8 2BN, UK
    David M. Evans, John P. Kemp & George Davey Smith
  27. Department of Medical Genetics, University of Lausanne, Lausanne, CH-1005, Switzerland
    Micha Hersch & Jacques S. Beckmann
  28. Swiss Institute of Bioinformatics, Lausanne, CH-1015, Switzerland
    Micha Hersch
  29. deCODE genetics, Reykjavik, 101, Iceland
    Hilma Holm, Daniel Fannar Gudbjartsson, Patrick Sulem, Unnur Thorsteinsdottir & Kari Stefansson
  30. Department of Biological Psychology, VU University, Amsterdam, 1081 BT, The Netherlands
    Jouke-Jan Hottenga, Abdel Abdellaoui, Eco J. C. de Geus, Marleen H. de Moor, Gonneke Willemsen & Dorret I. Boomsma
  31. Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, D-68167, Germany
    Marcus E. Kleber, Bernd Genser & Winfried Maerz
  32. LURIC Study nonprofit LLC, Freiburg, D-79098, Germany
    Marcus E. Kleber
  33. Radcliffe Department of Medicine, Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, UK
    Vasiliki Lagou & Inga Prokopenko
  34. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, UK
    Vasiliki Lagou & Inga Prokopenko
  35. MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke’s Hospital, Cambridge, CB2 0QQ, UK
    Claudia Langenberg, Jing Hua Zhao, Ruth J. F. Loos & Nicholas J. Wareham
  36. Department of Psychology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK
    Lorna M. Lopez & Ian J. Deary
  37. Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, EH8 9JZ, UK
    Lorna M. Lopez, Sarah E. Harris, John M. Starr, Ian J. Deary & Peter M. Visscher
  38. Department of Clinical Chemistry, Fimlab Laboratories, Tampere University Hospital, Tampere, FIN-33521, Finland
    Leo-Pekka Lyytikäinen & Terho Lehtimäki
  39. Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, FIN-33521, Finland
    Leo-Pekka Lyytikäinen & Terho Lehtimäki
  40. Department of Clinical Sciences, Lund University, 02Malmö, SE-205, Sweden
    Olle Melander, Gunnar Engström, Bo Hedblad & J. Gustav Smith
  41. Institute of Population Genetics, National Research Council of Italy, Sassari, 07100, Italy
    Federico Murgia, Laura Portas & Mario Pirastu
  42. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Ilja M. Nolte & Harold Snieder
  43. Institute of Cardiovascular and Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, G12 8QQ, United Kingdom
    Sandosh Padmanabhan, Claire E. Hastie & Anna F. Dominiczak
  44. University of Maryland School of Medicine, Baltimore, 21201, Maryland, USA
    Afshin Parsa, Quince D. Gibson, Braxton D. Mitchell & Alan R. Shuldiner
  45. Institute for Maternal and Child Health–IRCCS “Burlo Garofolo”–Trieste, University of Trieste, 34137 Trieste, Italy.,
    Nicola Pirastu, Giorgia Girotto, Antonietta Robino, Adamo Pio d’Adamo & Paolo Gasparini
  46. Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, c/o Cittadella Universitaria di Monserrato, Monserrato, Cagliari 09042, Italy.,
    Eleonora Porcu, Lucia Perseu, Francesco Cucca, Serena Sanna & Manuela Uda
  47. Institute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany
    Janina S. Ried & Christian Gieger
  48. Queensland Institute of Medical Research, Brisbane, 4006, Queensland, Australia
    Clara S. Tang, Beben Benyamin, Sarah E. Medland, John B. Whitfield, Nicholas G. Martin, Grant W. Montgomery, Peter M. Visscher & Manuel A. Ferreira
  49. Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, D-17487, Germany
    Alexander Teumer & Uwe Völker
  50. Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, 20132, Italy
    Michela Traglia, Giorgio Pistis, Cinzia Sala & Daniela Toniolo
  51. Institute for Maternal and Child Health - IRCCS “Burlo Garofolo”- Trieste, Trieste, 34137, Italy
    Sheila Ulivi
  52. University of Queensland Diamantina Institute, The University of Queensland, Princess Alexandra Hospital, Brisbane, 4102, Queensland, Australia
    Jian Yang & Peter M. Visscher
  53. Inserm, CESP Centre for research in Epidemiology and Population Health, U1018, Villejuif F-94807, France.,
    Beverley Balkau
  54. University Paris Sud 11, UMRS 1018, Villejuif, F-94807, France
    Beverley Balkau
  55. Geriatric Unit, Azienda Sanitaria Firenze, Florence, 50125, Italy
    Stefania Bandinelli
  56. Centre Hospitalier Universitaire Vaudois, Lausanne, CH-1011, Switzerland
    François Bastardot & Peter Vollenweider
  57. Department of Internal Medicine, University of Lausanne, Lausanne, CH-1011, Switzerland
    François Bastardot & Peter Vollenweider
  58. Queensland Brain Institute, The University of Queensland, Brisbane, 4072, Queensland, Australia
    Beben Benyamin & Peter M. Visscher
  59. Division of Endocrinology and Diabetes, Department of Medicine, University Hospital, Ulm, D-89075, Germany
    Bernhard O. Boehm
  60. The Hatter Cardiovascular Institute, University College London, London, WC1E 6HX, UK
    Debashish Das
  61. Division of Genetics, Brigham and Women’s Hospital, Harvard Medical School, Boston, 02115, Massachusetts, USA
    Paul I. W. de Bakker
  62. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, 02142, Massachusetts, USA
    Paul I. W. de Bakker
  63. Nutrition and Dietetics, Harokopio University, Athens, 17671, Kallithea, Greece
    Maria Dimitriou & George V. Dedoussis
  64. Institute of Epidemiology I and Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany
    Angela Döring
  65. The Laboratory in Mjodd, Reykjavik, 108, Iceland
    Gudmundur Ingi Eyjolfsson
  66. Clinical Research Branch, National Institute on Aging, Baltimore, 21250, Maryland, USA
    Luigi Ferrucci & Toshiko Tanaka
  67. Instituto de Saúde Coletiva, Federal University of Bahia, Salvador, 40110-040, Bahia, Brazil
    Quince D. Gibson
  68. Medical Genetics Section, The University of Edinburgh, Edinburgh, EH4 2XU, UK
    Sarah E. Harris
  69. Institute of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, FIN-90220, Finland
    Anna-Liisa Hartikainen
  70. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany
    Thomas Illig
  71. Hannover Unified Biobank, Hannover Medical School, Hannover, D-30625, Germany
    Thomas Illig
  72. Department of Clinical Physiology, Tampere University Hospital, Tampere, FIN-33521, Finland
    Mika Kähönen
  73. Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, FIN-33521, Finland
    Mika Kähönen
  74. Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Ido P. Kema & L. Joost van Pelt
  75. Department of Epidemiology, Department of Biostatistics, Harvard School of Public Health, Cambridge, Massachusetts 02115, USA.,
    Liming Liang
  76. Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, D-85764, Germany
    Christa Meisinger
  77. Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK
    Yasin Memari
  78. Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, D-17475, Germany
    Matthias Nauck
  79. Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, 101, Iceland
    Isleifur Olafsson
  80. Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
    Pall T. Onundarson
  81. Laboratory of Hematology and Coagulation Disorder Center, Landspitali University Hospital, Reykjavik, 101, Iceland
    Pall T. Onundarson
  82. Genetic Park of Ogliastra, Perdasdefogu, Sardinia, Italy
    Debora Parracciani
  83. Department of Psychiatry/EMGO Institute/Neuroscience Campus, VU University Medical Centre, Amsterdam, 1081 BT, The Netherlands
    Brenda W. Penninx & Johannes H. Smit
  84. Department of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Brenda W. Penninx
  85. Department of Psychiatry, Leiden University Medical Centre, Leiden, 2333, The Netherlands
    Brenda W. Penninx
  86. Division of Pediatrics and Thalassemia Centre, Department of Clinical and Biological Sciences, University of Torino, Turin, 10043, Orbassano, Italy
    Antonio Piga
  87. Institute of Health Sciences, University of Oulu, Oulu, FIN-90220, Finland
    Anneli Pouta & Marjo-Riitta Jarvelin
  88. National Institute of Health and Welfare, Aapistie 1, P.O. Box 310, FIN-90101 Oulu, Finland.,
    Anneli Pouta
  89. Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, FIN-20521, Finland
    Olli Raitakari
  90. Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, FIN-20521, Finland
    Olli Raitakari
  91. The School of Social and Community Medicine, University of Bristol, Bristol, BS8 2PS,, UK
    Susan M. Ring
  92. Institute of Diagnostics, University of Oulu, Oulu, FIN-90014, Finland
    Aimo Ruokonen
  93. Competence Centre on Reproductive Medicine and Biology, Tartu, 50410, Estonia
    Andres Salumets
  94. Institute of General and Molecular Pathology, University of Tartu, Tartu, 51014, Estonia
    Andres Salumets
  95. Department of Experimental Hematology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Hein Schepers
  96. Department of Stem Cell Biology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Hein Schepers
  97. Institute for Community Medicine, University Medicine Greifswald, Greifswald, D-17475, Germany
    Carsten Oliver Schmidt
  98. Departments of Human Genetics and Medicine, Faculty of Medicine, McGill University, Montreal, Quebec, H3A 1B1, Canada
    Rob Sladek
  99. Geriatric Medicine Unit, The University of Edinburgh, Western General Hospital, Edinburgh EH4 2XU, UK.,
    John M. Starr
  100. Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
    Unnur Thorsteinsdottir & Kari Stefansson
  101. ClinPhenomics Study Center, Frankfurt, D-60594, Germany
    Bernhard R. Winkelmann
  102. Department of Neurology and Neurosurgery, Utrecht Stroke Center, Rudolf Magnus Institute of Neuroscience, University Medical Center Utrecht, Utrecht, 3584 CG, The Netherlands
    Ale Algra
  103. Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, 07100, Italy
    Francesco Cucca
  104. Department of Public Health and Primary Care, University of Cambridge, Cambridge, CB1 8RN, UK
    John Danesh & Carmel Moore
  105. MRC-HPA Centre for Environment and Health, Imperial College London, London, W2 1PG, UK
    Paul Elliott & Marjo-Riitta Jarvelin
  106. Department of Cancer Biology, Thomas Jefferson University Jefferson Medical College, Philadelphia, 19107, Pennsylvania, USA
    Paolo Fortina
  107. Dipartimento di Medicina Molecolare, Università La Sapienza, Roma, 00161, Italy
    Paolo Fortina
  108. Centre National de la Recherche Scientifique (CNRS)-Unité mixte de recherche (UMR) 8199, Lille Pasteur Institute, Lille, 59100, France
    Philippe Froguel
  109. Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, W2 1PG, UK
    Philippe Froguel
  110. Institute for Immunology and Transfusion Medicine, University Medicine Greifswald, Greifswald, D-17487, Germany
    Andreas Greinacher
  111. Department of Cell Biology, Center for Cardiovascular Diagnostics and Prevention, Lerner Research Institute, Cleveland Clinic, Cleveland, 44195, Ohio, USA
    Stanley L. Hazen & W. H. Wilson Tang
  112. Department of Lifecourse snd Service, National Institute for Health and Welfare, Oulu, FIN-90101, Finland
    Marjo-Riitta Jarvelin
  113. Biocenter Oulu, University of Oulu, Oulu, FIN-90220, Finland
    Marjo-Riitta Jarvelin
  114. Clinical Gerontology Unit, Box 251, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK.,
    Kay Tee Khaw
  115. Synlab Academy, D-68165 Mannheim, Germany.,
    Winfried Maerz
  116. Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Gerjan Navis
  117. Department of Neurology, General Central Hospital, Bolzano, 39100, Italy
    Peter P. Pramstaller
  118. Department of Neurology, University of Lübeck, D-23538 Lübeck, Germany.,
    Peter P. Pramstaller
  119. Institute for Genomics and Multiscale Biology, Mount Sinai School of Medicine, New York, 10029-6574, USA
    Eric Schadt
  120. Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, 21201, Maryland, USA
    Alan R. Shuldiner
  121. Department of Cardiology, Lund University, Lund, 22185, Sweden
    J. Gustav Smith
  122. Department of Twin Research and Genetic Epidemiology, Kings College London, London, SE1 7EH, UK
    Tim D. Spector
  123. Department of Medicine, University of Leipzig, Liebigstr. 18, D-04103 Leipzig, Germany.,
    Michael Stumvoll & Anke Tönjes
  124. University of Leipzig, IFB AdiposityDiseases, Leipzig, D-04103, Germany
    Michael Stumvoll & Anke Tönjes
  125. Insitute of Molecular Genetics, CNR, 27100 Pavia, Italy.,
    Daniela Toniolo
  126. Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, 9700 RB, The Netherlands
    Bruce H. R. Wolffenbuttel
  127. Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois, Lausanne, 1011, Switzerland
    Jacques S. Beckmann
  128. Imperial College Healthcare NHS Trust, London, W12 0HS, UK
    Jaspal S. Kooner & John C. Chambers

Authors

  1. Pim van der Harst
  2. Weihua Zhang
  3. Irene Mateo Leach
  4. Augusto Rendon
  5. Niek Verweij
  6. Joban Sehmi
  7. Dirk S. Paul
  8. Ulrich Elling
  9. Hooman Allayee
  10. Xinzhong Li
  11. Aparna Radhakrishnan
  12. Sian-Tsung Tan
  13. Katrin Voss
  14. Christian X. Weichenberger
  15. Cornelis A. Albers
  16. Abtehale Al-Hussani
  17. Folkert W. Asselbergs
  18. Marina Ciullo
  19. Fabrice Danjou
  20. Christian Dina
  21. Tõnu Esko
  22. David M. Evans
  23. Lude Franke
  24. Martin Gögele
  25. Jaana Hartiala
  26. Micha Hersch
  27. Hilma Holm
  28. Jouke-Jan Hottenga
  29. Stavroula Kanoni
  30. Marcus E. Kleber
  31. Vasiliki Lagou
  32. Claudia Langenberg
  33. Lorna M. Lopez
  34. Leo-Pekka Lyytikäinen
  35. Olle Melander
  36. Federico Murgia
  37. Ilja M. Nolte
  38. Paul F. O’Reilly
  39. Sandosh Padmanabhan
  40. Afshin Parsa
  41. Nicola Pirastu
  42. Eleonora Porcu
  43. Laura Portas
  44. Inga Prokopenko
  45. Janina S. Ried
  46. So-Youn Shin
  47. Clara S. Tang
  48. Alexander Teumer
  49. Michela Traglia
  50. Sheila Ulivi
  51. Harm-Jan Westra
  52. Jian Yang
  53. Jing Hua Zhao
  54. Franco Anni
  55. Abdel Abdellaoui
  56. Antony Attwood
  57. Beverley Balkau
  58. Stefania Bandinelli
  59. François Bastardot
  60. Beben Benyamin
  61. Bernhard O. Boehm
  62. William O. Cookson
  63. Debashish Das
  64. Paul I. W. de Bakker
  65. Rudolf A. de Boer
  66. Eco J. C. de Geus
  67. Marleen H. de Moor
  68. Maria Dimitriou
  69. Francisco S. Domingues
  70. Angela Döring
  71. Gunnar Engström
  72. Gudmundur Ingi Eyjolfsson
  73. Luigi Ferrucci
  74. Krista Fischer
  75. Renzo Galanello
  76. Stephen F. Garner
  77. Bernd Genser
  78. Quince D. Gibson
  79. Giorgia Girotto
  80. Daniel Fannar Gudbjartsson
  81. Sarah E. Harris
  82. Anna-Liisa Hartikainen
  83. Claire E. Hastie
  84. Bo Hedblad
  85. Thomas Illig
  86. Jennifer Jolley
  87. Mika Kähönen
  88. Ido P. Kema
  89. John P. Kemp
  90. Liming Liang
  91. Heather Lloyd-Jones
  92. Ruth J. F. Loos
  93. Stuart Meacham
  94. Sarah E. Medland
  95. Christa Meisinger
  96. Yasin Memari
  97. Evelin Mihailov
  98. Kathy Miller
  99. Miriam F. Moffatt
  100. Matthias Nauck
  101. Maria Novatchkova
  102. Teresa Nutile
  103. Isleifur Olafsson
  104. Pall T. Onundarson
  105. Debora Parracciani
  106. Brenda W. Penninx
  107. Lucia Perseu
  108. Antonio Piga
  109. Giorgio Pistis
  110. Anneli Pouta
  111. Ursula Puc
  112. Olli Raitakari
  113. Susan M. Ring
  114. Antonietta Robino
  115. Daniela Ruggiero
  116. Aimo Ruokonen
  117. Aude Saint-Pierre
  118. Cinzia Sala
  119. Andres Salumets
  120. Jennifer Sambrook
  121. Hein Schepers
  122. Carsten Oliver Schmidt
  123. Herman H. W. Silljé
  124. Rob Sladek
  125. Johannes H. Smit
  126. John M. Starr
  127. Jonathan Stephens
  128. Patrick Sulem
  129. Toshiko Tanaka
  130. Unnur Thorsteinsdottir
  131. Vinicius Tragante
  132. Wiek H. van Gilst
  133. L. Joost van Pelt
  134. Dirk J. van Veldhuisen
  135. Uwe Völker
  136. John B. Whitfield
  137. Gonneke Willemsen
  138. Bernhard R. Winkelmann
  139. Gerald Wirnsberger
  140. Ale Algra
  141. Francesco Cucca
  142. Adamo Pio d’Adamo
  143. John Danesh
  144. Ian J. Deary
  145. Anna F. Dominiczak
  146. Paul Elliott
  147. Paolo Fortina
  148. Philippe Froguel
  149. Paolo Gasparini
  150. Andreas Greinacher
  151. Stanley L. Hazen
  152. Marjo-Riitta Jarvelin
  153. Kay Tee Khaw
  154. Terho Lehtimäki
  155. Winfried Maerz
  156. Nicholas G. Martin
  157. Andres Metspalu
  158. Braxton D. Mitchell
  159. Grant W. Montgomery
  160. Carmel Moore
  161. Gerjan Navis
  162. Mario Pirastu
  163. Peter P. Pramstaller
  164. Ramiro Ramirez-Solis
  165. Eric Schadt
  166. James Scott
  167. Alan R. Shuldiner
  168. George Davey Smith
  169. J. Gustav Smith
  170. Harold Snieder
  171. Rossella Sorice
  172. Tim D. Spector
  173. Kari Stefansson
  174. Michael Stumvoll
  175. W. H. Wilson Tang
  176. Daniela Toniolo
  177. Anke Tönjes
  178. Peter M. Visscher
  179. Peter Vollenweider
  180. Nicholas J. Wareham
  181. Bruce H. R. Wolffenbuttel
  182. Dorret I. Boomsma
  183. Jacques S. Beckmann
  184. George V. Dedoussis
  185. Panos Deloukas
  186. Manuel A. Ferreira
  187. Serena Sanna
  188. Manuela Uda
  189. Andrew A. Hicks
  190. Josef Martin Penninger
  191. Christian Gieger
  192. Jaspal S. Kooner
  193. Willem H. Ouwehand
  194. Nicole Soranzo
  195. John C. Chambers

Contributions

Study organisation: J.C.C., C.G., P.v.d.H., J.S.K., W.H.O. and N.S. Manuscript preparation: H.A., J.S.B., J.C.C., G.V.D., P.D., C.G., P.v.d.H., A.A.Hicks, J.S.K., I.M.-L., W.H.O., A.Radhakrishnan, A.Rendon, S.S., J.Sehmi, N.S., D.S.P., M.U., N.V. and W.Z. All authors reviewed and had the opportunity to comment on the manuscript. Data collection and analysis in the participating genome-wide association, replication and phenotype cohorts: ALSPAC: D.M.E., J.P.K., S.M.R., G.D.S; AMISH: Q.D.G., B.D.M., A.Parsa, A.R.S.; Beta-thalassaemia: F.A., F.D., P.Fortina, R.G, L.Perseu, A.Piga, S.S., M.U.; CBR: A.Attwood, J.D., S.F.G., H.L.-J., C.Moore, W.H.O., J.Sambrook; CoLAUS: F.B., J.S.B., M.H., P.V.; DeCODE: G.I.E., D.F.G., H.H., I.O., P.T.O., K.S., P.S., U.T.; DESIR: B.Balkau, C.D., P.Froguel, R.Sladek; EGCUT: T.E., K.F., A.M., E.M., A.S.; EPIC: K.-T.K., C.L., R.J.F.L., N.J.W., J.-H.Z.; Genebank: H.A., J.H., S.L.H., W.H.W.T.; INGI CARL: P.G., G.G., N.P.; INGI CILENTO: M.C., T.N., D.R., R.Sorice.; INGI FVG: A.P.d.A., A.Robino, S.U.; INGI Val Borbera: G.P., C.S., D.T., M.T.; KORA: A.D., C.G., T.I., C.Meisinger, J.S.R.; LBC: I.J.D., S.E.H., L.M.L., J.M.S.; LIFELINES: R.A.d.B., I.P.K., I.M.-L., G.N., P.v.d.H., L.J.v.P., N.V., B.H.R.W.; LOLIPOP: A.Al-Hussani, J.C.C., D.D., P.E., J.S.K., X.L., K.M., J.Scott, J.Sehmi, S.-T.T., W.Z.; LURIC: B.G., B.O.B., M.E.K., W.M., B.R.W.; MDC: A.F.D., G.E., B.H., C.E.H., O.M., S.P., J.G.S.; MICROS: M.G., A.AHicks, A.S.-P., P.P.P.; NESDA: I.M.N., B.W.P., J.H.S., H.Snieder; NFBC1966: A.-L.H., M.-R.J., P.F.O., A.Pouta, A.Ruokonen.; NTR: A.Abdellaoui, D.I.B., E.J.C.d.G., J.-J.H., M.H.d.M., G.Willemsen; OGP: F.M., D.P., L.Portas, M.P.; PREVEND: R.A.d.B., I.M.-L., G.N., P.v.d.H., W.H.v.G., D.J.v.V., N.V.; QIMR: B.Benyamin, M.A.F., N.G.M., S.E.M., G.W.M., C.S.T., P.M.V., J.B.W.; SardiNIA: F.C., E.P., S.S., M.U.; SHIP: A.G., M.Nauck, C.O.S., A.Teumer, U.V.; SMART: A.Algra, F.W.A., P.I.W.d.B., V.T.; SORBS: V.L., I.P., M.S., A.Tönjes.; TwinsUK: Y.M., S.-Y.S., N.S., T.D.S.; UKBS: J.J., W.H.O., N.S., J.Stephens; Young Finns: M.K., T.L., L.-P.L., O.R. Functional studies: Drosophila, U.E., F.S.D., A.A.Hicks, M.Novatchkova, J.M.P., U.P., C.X.W., G.Wirnsberger; expression profiling, W.O.C., L.Franke, L.L., M.F.M., A.Rendon, E.S., H.-J.W.; FAIRE, C.A.A., P.D., W.H.O., D.S.P., A.Rendon, N.S. Data analysis and bioinformatics: A.Al-Hussani, S.B., J.C.C., M.D., L.Ferrucci, P.v.d.H., S.K., X.L., I.M.-L., K.M., S.M., A.Radhakrishnan, A.Rendon, R.R.-S., H.Schepers, J.Sehmi, N.S., H.H.W.S., S.T., T.T., N.V., K.V., P.V., J.Y., W.Z.

Corresponding authors

Correspondence toPim van der Harst, Christian Gieger, Jaspal S. Kooner, Willem H. Ouwehand, Nicole Soranzo or John C. Chambers.

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Competing interests

The authors declare no competing financial interests.

Supplementary information

Supplementary Information

This file contains Supplementary Notes, Supplementary Tables 1-3 and 6-26 (see separate files for Supplementary Tables 4 and 5), Supplementary References and Supplementary Figures 1-8 – see contents list for details. (PDF 9711 kb)

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Supplementary Tables

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van der Harst, P., Zhang, W., Mateo Leach, I. et al. Seventy-five genetic loci influencing the human red blood cell.Nature 492, 369–375 (2012). https://doi.org/10.1038/nature11677

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