Modulation of allostery by protein intrinsic disorder (original) (raw)

References

  1. Hilser, V. J. & Thompson, E. B. Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins. Proc. Natl Acad. Sci. USA 104, 8311–8315 (2007)
    Article CAS ADS Google Scholar
  2. Garcia-Pino, A. et al. Allostery and intrinsic disorder mediate transcription regulation by conditional cooperativity. Cell 142, 101–111 (2010)
    Article CAS Google Scholar
  3. Dyson, H. J. & Wright, P. E. Intrinsically unstructured proteins and their functions. Nature Rev. Mol. Cell Biol. 6, 197–208 (2005)
    Article CAS Google Scholar
  4. Xie, H. et al. Functional anthology of intrinsic disorder. 1. Biological processes and functions of proteins with long disordered regions. J. Proteome Res. 6, 1882–1898 (2007)
    Article CAS Google Scholar
  5. Pelka, P., Ablack, J. N., Fonseca, G. J., Yousef, A. F. & Mymryk, J. S. Intrinsic structural disorder in adenovirus E1A: a viral molecular hub linking multiple diverse processes. J. Virol. 82, 7252–7263 (2008)
    Article CAS Google Scholar
  6. Ferrari, R. et al. Epigenetic reprogramming by adenovirus e1a. Science 321, 1086–1088 (2008)
    Article CAS ADS Google Scholar
  7. Horwitz, G. A. et al. Adenovirus small e1a alters global patterns of histone modification. Science 321, 1084–1085 (2008)
    Article CAS ADS Google Scholar
  8. Uversky, V. N., Oldfield, C. J. & Dunker, A. K. Intrinsically disordered proteins in human diseases: introducing the D2 concept. Annu. Rev. Biophys. 37, 215–246 (2008)
    Article CAS Google Scholar
  9. Davey, N. E., Trave, G. & Gibson, T. J. How viruses hijack cell regulation. Trends Biochem. Sci. 36, 159–169 (2011)
    Article CAS Google Scholar
  10. Berk, A. J. Recent lessons in gene expression, cell cycle control, and cell biology from adenovirus. Oncogene 24, 7673–7685 (2005)
    Article CAS Google Scholar
  11. Ferreon, J. C., Martinez-Yamout, M. A., Dyson, H. J. & Wright, P. E. Structural basis for subversion of cellular control mechanisms by the adenoviral E1A oncoprotein. Proc. Natl Acad. Sci. USA 106, 13260–13265 (2009)
    Article CAS ADS Google Scholar
  12. Liu, X. & Marmorstein, R. Structure of the retinoblastoma protein bound to adenovirus E1A reveals the molecular basis for viral oncoprotein inactivation of a tumor suppressor. Genes Dev. 21, 2711–2716 (2007)
    Article CAS Google Scholar
  13. Ferreon, A. C. M., Moran, C. R., Gambin, Y. & Deniz, A. A. Single-molecule fluorescence studies of intrinsically disordered proteins. Methods Enzymol. 472, 179–204 (2010)
    Article CAS Google Scholar
  14. Deniz, A. A., Mukhopadhyay, S. & Lemke, E. A. Single-molecule biophysics: at the interface of biology, physics and chemistry. J. R. Soc. Interface 5, 15–45 (2008)
    Article CAS Google Scholar
  15. Lee, J.-O., Russo, A. A. & Pavletich, N. P. Structure of the retinoblastoma tumour-suppressor pocket domain bound to a peptide from HPV E7. Nature 391, 859–865 (1998)
    Article CAS ADS Google Scholar
  16. Ferreon, A. C. M., Ferreon, J. C., Bolen, D. W. & Rösgen, J. Protein phase diagrams II: nonideal behavior of biochemical reactions in the presence of osmolytes. Biophys. J. 92, 245–256 (2007)
    Article CAS ADS Google Scholar
  17. Kuriyan, J. & Eisenberg, D. The origin of protein interactions and allostery in colocalization. Nature 450, 983–990 (2007)
    Article CAS ADS Google Scholar
  18. Heise, C. et al. An adenovirus E1A mutant that demonstrates potent and selective systemic anti-tumoral efficacy. Nature Med. 6, 1134–1139 (2000)
    Article CAS Google Scholar
  19. Hilser, V. J. & Thompson, E. B. Intrinsic disorder as a mechanism to optimize allosteric coupling in proteins. Proc. Natl Acad. Sci. USA 104, 8311–8315 (2007)
    Article CAS ADS Google Scholar
  20. Cui, Q. & Karplus, M. Allostery and cooperativity revisited. Protein Sci. 17, 1295–1307 (2008)
    Article CAS Google Scholar
  21. Wang, H.-G. H., Moran, E. & Yaciuk, P. E1A promotes association between p300 and pRB in multimeric complexes required for normal biological activity. J. Virol. 69, 7917–7924 (1995)
    CAS PubMed PubMed Central Google Scholar
  22. Chan, H. M., Krstic-Demonacos, M., Smith, L., Demonacos, C. & La Thangue, N. B. Acetylation control of the retinoblastoma tumour-suppressor protein. Nature Cell Biol. 3, 667–674 (2001)
    Article CAS Google Scholar
  23. Nguyen, D. X., Baglia, L. A., Huang, S.-M., Baker, C. M. & McCance, D. J. Acetylation regulates the differentiation-specific functions of the retinoblastoma protein. EMBO J. 23, 1609–1618 (2004)
    Article CAS Google Scholar
  24. Koshland, D. E., Jr The structural basis of negative cooperativity: receptors and enzymes. Curr. Opin. Struct. Biol. 6, 757–761 (1996)
    Article CAS Google Scholar
  25. Sang, N., Avantaggiati, M. L. & Giordano, A. Roles of p300, pocket proteins, and hTBP in E1A-mediated transcriptional regulation and inhibition of p53 transactivation activity. J. Cell. Biochem. 66, 277–285 (1997)
    Article CAS Google Scholar
  26. Green, M., Panesar, N. K. & Loewenstein, P. M. The transcription-repression domain of the adenovirus E1A oncoprotein targets p300 at the promoter. Oncogene 27, 4446–4455 (2008)
    Article CAS Google Scholar
  27. Motlagh, H. N. & Hilser, V. J. Agonism/antagonism switching in allosteric ensembles. Proc. Natl Acad. Sci. USA 109, 4134–4139 (2012)
    Article CAS ADS Google Scholar
  28. Modrek, B. & Lee, C. A genomic view of alternative splicing. Nature Genet. 30, 13–19 (2002)
    Article CAS Google Scholar
  29. Lee, C. W., Ferreon, J. C., Ferreon, A. C. M., Arai, M. A. & Wright, P. E. Graded enhancement of p53 binding to CBP/p300 by multisite phosphorylation. Proc. Natl Acad. Sci. USA 107, 19290–19295 (2010)
    Article CAS ADS Google Scholar
  30. Ferreon, A. C. M., Gambin, Y., Lemke, E. A. & Deniz, A. A. Interplay of α-synuclein binding and conformational switching probed by single-molecule fluorescence. Proc. Natl Acad. Sci. USA 106, 5645–5650 (2009)
    Article CAS ADS Google Scholar
  31. Kadri, Z. et al. Direct binding of pRb/E2F-2 to GATA-1 regulates maturation and terminal cell division during erythropoiesis. PLoS Biol. 7, 1–15 (2009)
    Article Google Scholar
  32. Rösgen, J. & Hinz, H. J. Phase diagrams: a graphical representation of linkage relations. J. Mol. Biol. 328, 255–271 (2003)
    Article Google Scholar

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