Addendum: Enterotypes of the human gut microbiome (original) (raw)

Nature 473, 174–180 (2011); doi:10.1038/nature09944 and corrigendum 474, 666 (2011); doi:10.1038/nature10187

It has been drawn to our attention that the methods described in the main text and the Supplementary Information of this Article have been considered by some researchers to be insufficient to enable them to identify enterotypes in their own data sets. Enterotypes were originally defined in this Article (page 177) as “densely populated areas in a multi-dimensional space of community composition” and should not be seen as discrete clusters, but as a way of stratifying samples to reduce complexity. Additionally, the Fig. 2 legend should not imply that between-class analysis is simply a method of visualizing principal component analysis (PCA); rather, it is a supervised rather than an unsupervised analysis of data because it incorporates the outcome of clustering of data. To simplify enterotype identification in the original and other data sets, we have developed a comprehensive tutorial at http://enterotype.embl.de—which is a website on enterotypes that will be updated as methods improve. We thank Ivica Letunic and Paul Costea from EMBL for setting up the tutorial.

Authors

  1. Manimozhiyan Arumugam
  2. Jeroen Raes
  3. Eric Pelletier
  4. Denis Le Paslier
  5. Takuji Yamada
  6. Daniel R. Mende
  7. Gabriel R. Fernandes
  8. Julien Tap
  9. Thomas Bruls
  10. Jean-Michel Batto
  11. Marcelo Bertalan
  12. Natalia Borruel
  13. Francesc Casellas
  14. Leyden Fernandez
  15. Laurent Gautier
  16. Torben Hansen
  17. Masahira Hattori
  18. Tetsuya Hayashi
  19. Michiel Kleerebezem
  20. Ken Kurokawa
  21. Marion Leclerc
  22. Florence Levenez
  23. Chaysavanh Manichanh
  24. H. Bjørn Nielsen
  25. Trine Nielsen
  26. Nicolas Pons
  27. Julie Poulain
  28. Junjie Qin
  29. Thomas Sicheritz-Ponten
  30. Sebastian Tims
  31. David Torrents
  32. Edgardo Ugarte
  33. Erwin G. Zoetendal
  34. Jun Wang
  35. Francisco Guarner
  36. Oluf Pedersen
  37. Willem M. de Vos
  38. Søren Brunak
  39. Joel Doré
  40. MetaHIT Consortium
  41. Jean Weissenbach
  42. S. Dusko Ehrlich
  43. Peer Bork

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Arumugam, M., Raes, J., Pelletier, E. et al. Addendum: Enterotypes of the human gut microbiome.Nature 506, 516 (2014). https://doi.org/10.1038/nature13075

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