Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion (original) (raw)

References

  1. Weissman, I. L. Translating stem and progenitor cell biology to the clinic: barriers and opportunities. Science 287, 1442–1446 (2000)
    Article ADS CAS Google Scholar
  2. Wilmut, I., Schnieke, A. E., McWhir, J., Kind, A. J. & Campbell, K. H. Viable offspring derived from fetal and adult mammalian cells. Nature 385, 810–813 (1997)
    Article ADS CAS Google Scholar
  3. Clarke, D. L. et al. Generalized potential of adult neural stem cells. Science 288, 1660–1663 (2000)
    Article ADS CAS Google Scholar
  4. Pittenger, M. F. et al. Multilineage potential of adult human mesenchymal stem cells. Science 284, 143–147 (1998)
    Article ADS Google Scholar
  5. Ferrari, G. et al. Muscle regeneration by bone marrow-derived myogenic progenitors. Science 279, 1528–1530 (1998)
    Article ADS CAS Google Scholar
  6. Petersen, B. E. et al. Bone marrow as a potential source of hepatic oval cells. Science 284, 1168–1170 (1999)
    Article ADS CAS Google Scholar
  7. Theise, N. D. et al. Liver from bone marrow in human. Hepatology 32, 11–16 (2000)
    Article CAS Google Scholar
  8. Lagasse, E. et al. Purified hematopoietic stem cells can differentiate into hepatocytes in vivo. Nature Med. 6, 1229–1234 (2000)
    Article CAS Google Scholar
  9. Brazelton, T. R., Rossi, F. M. V., Keshet, G. I. & Blau, H. M. From marrow to brain: expression of neuronal phenotypes in adult mice. Science 290, 1775–1779 (2000)
    Article ADS CAS Google Scholar
  10. Mezey, E., Chandross, K. J., Harta, G., Maki, R. A. & McKercher, S. R. Turning blood into brain: cells bearing neuronal antigens generated in vivo from bone marrow. Science 290, 1779–1782 (2000)
    Article ADS CAS Google Scholar
  11. Krause, D. S. et al. Multi-organ, multi-lineage engraftment by a single bone marrow-derived stem cell. Cell 105, 369–377 (2001)
    Article CAS Google Scholar
  12. Hadjantonakis, A. K., Gertsenstein, M., Ikawa, M., Okabe, M. & Nagy, A. Generating green fluorescent mice by germline transmission of green fluorescent ES cells. Mech. Dev. 76, 79–90 (1998)
    Article CAS Google Scholar
  13. Kawasome, H. et al. Targeted disruption of p70s6k defines its role in protein synthesis and rapamycin sensitivity. Proc. Natl Acad. Sci. USA 95, 5033–5038 (1998)
    Article ADS CAS Google Scholar
  14. Minamino, T. et al. MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes. Proc. Natl Acad. Sci. USA 96, 15127–15132 (1999)
    Article ADS CAS Google Scholar
  15. Hamazaki, T. et al. Hepatic maturation in differentiating embryonic stem cells in vitro. FEBS Lett. 497, 15–19 (2001)
    Article CAS Google Scholar
  16. Nichols, J. et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transciption factor Oct4. Cell 95, 379–391 (1998)
    Article CAS Google Scholar
  17. Nishimoto, M., Fukushima, A., Okuda, A. & Muramatsu, M. The gene for the embryonic stem cell coactivator UTF1 carries a regulatory element which selectively interacts with a complex composed of Oct-3/4 and Sox-2. Mol. Cell. Biol. 19, 5453–5465 (1999)
    Article CAS Google Scholar
  18. Kawasaki, H. et al. Induction of midbrain dopaminergic neurons from ES cells by stromal cell-derived inducing activity. Neuron 28, 31–40 (2000)
    Article CAS Google Scholar
  19. Everett, C. A. & West, J. D. The influence of ploidy on the distribution of cells in chimaeric mouse blastocysts. Zygote 4, 59–66 (1996)
    Article CAS Google Scholar
  20. Tada, M., Takahama, Y., Abe, K., Nakatsuji, N. & Tada, T. Nuclear reprogramming of somatic cells by in vitro hybridization with ES cells. Curr. Biol. 11, 1553–1558 (2001)
    Article CAS Google Scholar
  21. Tada, M., Tada, T., Lefebvre, L., Barton, S. C. & Syrani, M. A. Embryonic germ cells induce epigenetic reprogramming of somatic nucleus in hybrid cells. EMBO J. 16, 6510–6520 (1997)
    Article CAS Google Scholar
  22. Parwaresch, M. R., Kreipe, H. & Radzun, H. J. Human macrophage hybrid forming spontaneous giant cells. Virchows Arch. B 51, 89–96 (1986)
    Article CAS Google Scholar
  23. Chiozzi, P. et al. Spontaneous cell fusion in macrophage cultures expressing high levels of the P2Z/P2X7 receptor. J. Cell Biol. 138, 697–706 (1997)
    Article CAS Google Scholar
  24. Falzoni, S. et al. The purinergic P2Z receptor of human macrophage cells. Characterization and possible physiological role. J. Clin. Invest. 95, 1207–1216 (1995)
    Article CAS Google Scholar
  25. Enelow, R. I., Sullivan, G. W., Carper, H. T. & Mandell, G. L. Induction of multinucleated giant cell formation from in vitro culture of human monocytes with interleukin-3 and interferon-β: comparison with other stimulating factors. Am. J. Resp. Cell Mol. Biol. 6, 57–62 (1992)
    Article CAS Google Scholar

Download references