Shaggy/GSK3 antagonizes Hedgehog signalling by regulating Cubitus interruptus (original) (raw)
Cadigan, K. M. & Nusse, R. Wnt signalling: a common theme in animal development. Genes Dev.11, 3286–3305 (1997) ArticleCASPubMed Google Scholar
Aza-Blanc, P., Ramirez-Weber, F., Laget, M., Schwartz, C. & Kornberg, T. Proteolysis that is inhibited by Hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell89, 1043–1053 (1997) ArticleCASPubMed Google Scholar
Ohlmeyer, J. T. & Kalderon, D. Hedgehog stimulates maturation of Cubitus interruptus into a labile transcriptional activator. Nature396, 749–753 (1998) ArticleADSCASPubMed Google Scholar
Methot, N. & Basler, K. Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell96, 819–831 (1999) ArticleCASPubMed Google Scholar
Chen, C. H. et al. Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell98, 305–316 (1999) ArticleCASPubMed Google Scholar
Wang, G., Wang, B. & Jiang, J. Protein kinase A antagonizes Hedgehog signalling by regulating both the activator and repressor forms of Cubitus interruptus. Genes Dev.13, 2828–2837 (1999) ArticleCASPubMedPubMed Central Google Scholar
Preat, T. Characterization of Suppressor of fused, a complete suppressor of the fused segment polarity gene of Drosophila melanogaster. Genetics132, 725–736 (1992) CASPubMedPubMed Central Google Scholar
Ingham, P. W. Signaling by hedgehog family proteins in Drosophila and vertebrate development. Curr. Opin. Genet. Dev.5, 492–498 (1995) ArticleCASPubMed Google Scholar
Villavicencio, E. H., Walterhouse, D. O. & Iannaccone, P. M. The sonic hedgehog-patched-gli pathway in human development and disease. Am. J. Hum. Genet.67, 1047–1054 (2000) ArticleCASPubMedPubMed Central Google Scholar
Basler, K. & Struhl, G. Compartment boundaries and the control of Drosophila limb pattern by hedgehog protein. Nature368, 208–214 (1994) ArticleADSCASPubMed Google Scholar
Tabata, T. & Kornberg, T. B. Hedgehog is a signalling protein with a key role in patterning Drosophila imaginal discs. Cell76, 89–102 (1994) ArticleCASPubMed Google Scholar
Wang, Q. T. & Holmgren, R. A. The subcellular localization and activity of Drosophila cubitus interruptus are regulated at multiple levels. Development126, 5097–5106 (1999) CASPubMed Google Scholar
Yost, C. et al. GBP, an inhibitor of GSK-3, is implicated in Xenopus development and oncogenesis. Cell93, 1031–1041 (1998) ArticleCASPubMed Google Scholar
Jiang, J. & Struhl, G. Complementary and mutually exclusive activities of decapentaplegic and wingless organize axial patterning during Drosophila leg development. Cell86, 401–409 (1996) ArticleCASPubMed Google Scholar
Zecca, M., Basler, K. & Struhl, G. Direct and long-range action of a Wingless morphogen gradient. Cell87, 833–844 (1996) ArticleCASPubMed Google Scholar
Denef, N., Neubuser, D., Perez, L. & Cohen, S. M. Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell102, 521–531 (2000) ArticleCASPubMed Google Scholar
Price, M. A. & Kalderon, D. Proteolysis of cubitus interruptus in Drosophila requires phosphorylation by protein kinase A. Development126, 4331–4339 (1999) CASPubMed Google Scholar
Jiang, J. & Struhl, G. Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature391, 493–496 (1998) ArticleADSCASPubMed Google Scholar
Chen, Y., Cardinaux, J. R., Goodman, R. H. & Smolik, S. M. Mutants of cubitus interruptus that are independent of PKA regulation are independent of hedgehog signalling. Development126, 3607–3616 (1999) CASPubMed Google Scholar
Sisson, J. C., Ho, K. S., Suyama, K. & Scott, M. P. Costal2, a novel kinesin-related protein in the Hedgehog signalling pathway. Cell90, 235–245 (1997) ArticleCASPubMed Google Scholar
Wang, G., Amanai, K., Wang, B. & Jiang, J. Interactions with Costal2 and suppressor of fused regulate nuclear translocation and activity of cubitus interruptus. Genes Dev.14, 2893–2905 (2000) ArticleCASPubMedPubMed Central Google Scholar
Kim, L. & Kimmel, A. R. GSK3, a master switch regulating cell-fate specification and tumorigenesis. Curr. Opin. Genet. Dev.10, 508–514 (2000) ArticleCASPubMed Google Scholar
Brand, A. H. & Perrimon, N. Targeted gene expression as a means of altering cell fates and generating dominant phenotypes. Development118, 401–415 (1993) CASPubMed Google Scholar
Nash, P. et al. Multisite phosphorylation of a CDK inhibitor sets a threshold for the onset of DNA replication. Nature414, 514–521 (2001) ArticleADSCASPubMed Google Scholar
Ruiz i Altaba, A. Gli proteins and Hedgehog signalling: development and cancer. Trends Genet.15, 418–425 (1999) ArticleCASPubMed Google Scholar
Roelink, H. Tripartite signalling of pattern: interactions between Hedgehogs, BMPs and Wnts in the control of vertebrate development. Curr. Opin. Neurobiol.6, 33–40 (1995) Article Google Scholar
Ruel, L., Pantesco, Y., Lutz, P., Simpson, P. & Bourouis, M. Functional significance of a family of protein kinases encoded at the shaggy locus in Drosophila. EMBO J.12, 1657–1669 (1993) ArticleCASPubMedPubMed Central Google Scholar
Chen, Y. & Struhl, G. Dual roles for patched in sequestering and transducing Hedgehog. Cell87, 553–563 (1996) ArticleCASPubMed Google Scholar
Jiang, J. & Struhl, G. Protein kinase A and Hedgehog signalling in Drosophila limb development. Cell80, 563–572 (1995) ArticleCASPubMed Google Scholar