Smith, V., Chou, K.N., Lashkari, D., Botstein, D. & Brown, P.O. Functional analysis of the genes of yeast chromosome V by genetic footprinting. Science274, 2069–2074 (1996). ArticleCASPubMed Google Scholar
Winzeler, E.A. et al. Functional characterization of the S. cerevisiae genome by gene deletion and parallel analysis. Science285, 901–906 (1999). ArticleCASPubMed Google Scholar
Akerley, B.J. et al. Systematic identification of essential genes by in vitro mariner mutagenesis. Proc. Natl. Acad. Sci. USA95, 8927–8932 (1998). ArticleCASPubMedPubMed Central Google Scholar
Wong, S.M. & Mekalanos, J.J. Genetic footprinting with mariner-based transposition in Pseudomonas aeruginosa.Proc. Natl. Acad. Sci. USA97, 10191–10196 (2000). CAS Google Scholar
Hutchison, C.A. et al. Global transposon mutagenesis and a minimal Mycoplasma genome. Science286, 2165–2169 (1999). ArticleCASPubMed Google Scholar
Schena, M., Shalon, D., Davis, R.W. & Brown, P.O. Quantitative monitoring of gene expression patterns with a complementary DNA microarray. Science270, 467–470 (1995). ArticleCASPubMed Google Scholar
Iyer, V.R. et al. Genomic binding sites of the yeast cell-cycle transcription factors SBF and MBF. Nature409, 533–538 (2001). ArticleCASPubMed Google Scholar
Ren, B. et al. Genome-wide location and function of DNA binding proteins. Science290, 2306–2309 (2000). ArticleCASPubMed Google Scholar
Pollack, J.R. et al. Genome-wide analysis of DNA copy-number changes using cDNA microarrays. Nat. Genet.23, 41–46 (1999). ArticleCASPubMed Google Scholar
Alexeyev, M.F. & Shokolenko, I.N. Mini-Tn10 transposon derivatives for insertion mutagenesis and gene delivery into the chromosome of gram-negative bacteria. Gene160, 59–62 (1995). ArticleCASPubMed Google Scholar
Tavazoie, S. & Church, G.M. Quantitative whole-genome analysis of DNA–protein interactions by in vivo methylase protection in E. coli. Nat. Biotechnol.16, 566–571 (1998). ArticleCASPubMed Google Scholar
Robison, K., McGuire, A.M. & Church, G.M. A comprehensive library of DNA-binding site matrices for 55 proteins applied to the complete Escherichia coli K-12 genome. J. Mol. Biol.284, 241–254 (1998). ArticleCASPubMed Google Scholar
Arigoni, F. et al. A genome-based approach for the identification of essential bacterial genes. Nat. Biotechnol.16, 851–856 (1998). ArticleCASPubMed Google Scholar
Edwards, J.S. & Palsson, B.O. The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities. Proc. Natl. Acad. Sci. USA97, 5528–5533 (2000). ArticleCASPubMedPubMed Central Google Scholar
Edwards, J.S., Ibarra, R.U. & Palsson, B.O. In silico predictions of Escherichia coli metabolic capabilities are consistent with experimental data. Nat. Biotechnol.19, 125–130 (2001). ArticleCASPubMed Google Scholar
Zwaal, R.R., Broeks, A., van Meurs, J., Groenen, J.T. & Plasterk, R.H. Target-selected gene inactivation in Caenorhabditis elegans by using a frozen transposon insertion mutant bank. Proc. Natl. Acad. Sci. USA90, 7431–7435 (1993). ArticleCASPubMedPubMed Central Google Scholar
Giaever, G. et al. Genomic profiling of drug sensitivities via induced haploinsufficiency. Nat. Genet.21, 278–283 (1999). ArticleCASPubMed Google Scholar
Hicks, G.G. et al. Functional genomics in mice by tagged sequence mutagenesis. Nat. Genet.16, 338–344 (1997). ArticleCASPubMed Google Scholar
Zambrowicz, B.P. et al. Disruption and sequence identification of 2,000 genes in mouse embryonic stem cells. Nature392, 608–611 (1998). ArticleCASPubMed Google Scholar
Sambrook, J., Fritsch, E.F. & Maniatis, T. Molecular cloning: a laboratory manual. (Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY; 1989). Google Scholar
Ausubel, F.M. et al. Current protocols in molecular biology. (Wiley Interscience, New York, NY; 1994). Google Scholar
Marton, M.J. et al. Drug target validation and identification of secondary drug target effects using DNA microarrays. Nat. Med.4, 1293–1301 (1998). ArticleCASPubMed Google Scholar
Altschul, S.F., Gish, W., Miller, W., Myers, E.W., & Lipman, D.J. Basic local alignment search tool. J. Mol. Biol.215, 403–410 (1990). ArticleCASPubMed Google Scholar
Livesey, F.J., Furukawa, T., Steffen, M.A., Church, G.M. & Cepko, C.L. Microarray analysis of the transcriptional network controlled by the photoreceptor homeobox gene Crx. Curr. Biol.10, 301–310 (2000). CASPubMed Google Scholar