ROS as a tumour suppressor? (original) (raw)
- News & Views
- Published: 01 November 2006
Nature Cell Biology volume 8, pages 1213–1215 (2006)Cite this article
- 1674 Accesses
- 195 Citations
- 10 Altmetric
- Metrics details
Senescence is an important mechanism for suppressing mammalian tumours and it may also contribute to aging. A new study suggests that changes in the metabolism of oxygen radicals are important for establishing senescence and blocking cytokinesis to ensure senescent cells never divide again.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on SpringerLink
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
Additional access options:
Figure 1: Senescence requires a mitogenic signal under conditions of cellular stress.
References
- Finkel, T. Curr. Opin. Cell Biol. 15, 247–254 (2003).
Article CAS PubMed Central Google Scholar - Takahashi, A. et al. Nature Cell Biol. 8, 1291–1297 (2006).
Article CAS PubMed Central Google Scholar - Narita, M. & Lowe, S.W. Nature Med. 11, 920–922 (2005).
Article CAS PubMed Central Google Scholar - Michaloglou, C. et al. Nature 436, 720–724 (2005).
Article CAS PubMed Central Google Scholar - Gray-Schopfer, V.C. et al. Br. J. Cancer 95, 496–505 (2006).
Article CAS PubMed Central Google Scholar - Dai, C.Y. & Enders, G.H. Oncogene 19, 1613–1622 (2000).
Article CAS PubMed Central Google Scholar - Beausejour, C.M. et al. EMBO J. 22, 4212–4222 (2003).
Article CAS PubMed Central Google Scholar - Satyanarayana, A. et al. Mol. Cell Biol. 24, 5459–5474 (2004).
Article CAS PubMed Central Google Scholar - Narita, M. et al. Cell 113, 703–716 (2003).
Article CAS PubMed Central Google Scholar - Chen, J.H. et al. J. Biol. Chem. 279, 49439–49446 (2004).
Article CAS PubMed Central Google Scholar - Wheaton, K. & Riabowol, K. Mol. Cell Biol. 24, 7298–7311 (2004).
Article CAS PubMed Central Google Scholar - Watanabe, T. et al. Proc. Natl Acad. Sci. USA 89, 10159–10163 (1992).
Article CAS PubMed Central Google Scholar - The Alpha-Tocopherol, Beta Carotene Cancer Prevention Study Group. N. Engl. J. Med. 330, 1029–1035 (1994).
- Omenn, G.S. et al. N. Engl. J. Med. 334, 1150–1155 (1996).
Article CAS PubMed Central Google Scholar - Duffield-Lillico, A.J. & Begg, C.B. J. Natl Cancer. Inst. 96, 1729–1731 (2004).
Article CAS PubMed Central Google Scholar
Acknowledgements
We would like to thank W. Kim for comments of the manuscript.
Author information
Authors and Affiliations
- Departments of Medicine and Genetics, The Lineberger Comprehensive Cancer Center, The University of North Carolina School of Medicine, Chapel Hill, 27599-7295, NC, USA
Matthew R. Ramsey & Norman E. Sharpless
Authors
- Matthew R. Ramsey
You can also search for this author inPubMed Google Scholar - Norman E. Sharpless
You can also search for this author inPubMed Google Scholar
Rights and permissions
About this article
Cite this article
Ramsey, M., Sharpless, N. ROS as a tumour suppressor?.Nat Cell Biol 8, 1213–1215 (2006). https://doi.org/10.1038/ncb1106-1213
- Issue Date: 01 November 2006
- DOI: https://doi.org/10.1038/ncb1106-1213