G9a-mediated irreversible epigenetic inactivation of Oct-3/4 during early embryogenesis (original) (raw)

References

  1. Brehm, A., Ovitt, C. E. & Scholer, H. R. Oct-4: more than just a POUerful marker of the mammalian germline? Apmis 106, 114–126 (1998).
    Article CAS Google Scholar
  2. Pesce, M. & Scholer, H. R. Oct-4: control of totipotency and germline determination. Mol. Reprod. Dev. 55, 452–457 (2000).
    Article CAS Google Scholar
  3. Nichols, J. et al. Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95, 379–391 (1998).
    Article CAS Google Scholar
  4. Pikarsky, E., Sharir, H., Ben-Shushan, E. & Bergman, Y. Retinoic acid represses Oct-3/4 gene expression through several retinoic acid-responsive elements located in the promoter-enhancer region. Mol. Cell. Biol. 14, 1026–1038 (1994).
    Article CAS Google Scholar
  5. Okamoto, K. et al. A novel octamer binding transcription factor is differentially expressed in mouse embryonic cells. Cell 60, 461–472 (1990).
    Article CAS Google Scholar
  6. Ben-Shushan, E., Sharir, H., Pikarsky, E. & Bergman, Y. A dynamic balance between ARP-1/COUP-TFII, EAR-3/COUP-TFI, and retinoic acid receptor:retinoid X receptor heterodimers regulates Oct-3/4 expression in embryonal carcinoma cells. Mol. Cell. Biol. 15, 1034–1048 (1995).
    Article CAS Google Scholar
  7. Fuhrmann, G. et al. Mouse germline restriction of Oct4 expression by germ cell nuclear factor. Dev. Cell 1, 377–387 (2001).
    Article CAS Google Scholar
  8. Santos-Rosa, H. et al. Active genes are tri-methylated at K4 of histone H3. Nature 419, 407–411 (2002).
    Article CAS Google Scholar
  9. Lachner, M. & Jenuwein, T. The many faces of histone lysine methylation. Curr. Opin. Cell. Biol. 14, 286–298 (2002).
    Article CAS Google Scholar
  10. Kimura, H., Tada, M., Nakatsuji, N. & Tada, T. Histone code modifications on pluripotential nuclei of reprogrammed somatic cells. Mol. Cell. Biol. 24, 5710–5720 (2004).
    Article CAS Google Scholar
  11. Gidekel, S. & Bergman, Y. A unique developmental pattern of Oct-3/4 DNA methylation is controlled by a _cis_-demodification element. J. Biol. Chem. 277, 34521–34530 (2002).
    Article CAS Google Scholar
  12. Brandeis, M. et al. Sp1 elements protect a CpG island from de novo methylation. Nature 371, 435–438 (1994).
    Article CAS Google Scholar
  13. Ben-Shushan, E., Thompson, J. R., Gudas, L. J. & Bergman, Y. Rex-1, a gene encoding a transcription factor expressed in the early embryo, is regulated via Oct-3/4 and Oct-6 binding to an octamer site and a novel protein, Rox-1, binding to an adjacent site. Mol. Cell. Biol. 18, 1866–1878 (1998).
    Article CAS Google Scholar
  14. Okano, M., Bell, D. W., Haber, D. A. & Li, E. DNA methyltransferases Dnmt3a and Dnmt3b are essential for de novo methylation and mammalian development. Cell 99, 247–257 (1999).
    Article CAS Google Scholar
  15. Tachibana, M. et al. G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis. Genes Dev. 16, 1779–1791 (2002).
    Article CAS Google Scholar
  16. Stewart, M. D., Li, J. & Wong, J. Relationship between histone H3 lysine 9 methylation, transcription repression, and heterochromatin protein 1 recruitment. Mol. Cell. Biol. 25, 2525–2538 (2005).
    Article CAS Google Scholar
  17. Osipovich, O. et al. Targeted inhibition of V(D)J recombination by a histone methyltransferase. Nature Immunol. 5, 309–316 (2004).
    Article CAS Google Scholar
  18. Freitag, M. & Selker, E. U. Controlling DNA methylation: many roads to one modification. Curr. Opin. Genet. Dev. 15, 191–199 (2005).
    Article CAS Google Scholar
  19. Tachibana, M. et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9. Genes Dev. 19, 815–826 (2005).
    Article CAS Google Scholar
  20. Ayyanathan, K. et al. Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. Genes Dev. 17, 1855–1869 (2003).
    Article CAS Google Scholar
  21. Fahrner, J. A. & Baylin, S. B. Heterochromatin: stable and unstable invasions at home and abroad. Genes Dev. 17, 1805–1812 (2003).
    Article CAS Google Scholar
  22. Goldmit, M. et al. Epigenetic ontogeny of the k locus during B cell development. Nature Immunol. 6, 198–203 (2005).
    Article CAS Google Scholar
  23. Boiani, M., Eckardt, S., Scholer, H. R. & McLaughlin, K. J. Oct4 distribution and level in mouse clones: consequences for pluripotency. Genes Dev. 16, 1209–1219 (2002).
    Article CAS Google Scholar
  24. Bortvin, A. et al. Incomplete reactivation of Oct4-related genes in mouse embryos cloned from somatic nuclei. Development 130, 1673–1680 (2003).
    Article CAS Google Scholar
  25. Simonsson, S. & Gurdon, J. DNA demethylation is necessary for the epigenetic reprogramming of somatic cell nuclei. Nature Cell Biol. 6, 984–990 (2004).
    Article CAS Google Scholar
  26. Jorgensen, H. F., Ben-Porath, I. & Bird, A. P. Mbd1 is recruited to both methylated and nonmethylated CpGs via distinct DNA binding domains. Mol. Cell. Biol. 24, 3387–3395 (2004).
    Article CAS Google Scholar
  27. Ji, Y., Zhang, J., Lee, A. I., Cedar, H. & Bergman, Y. A multistep mechanism for the activation of rearrangement in the immune system. Proc. Natl Acad. Sci. USA 100, 7557–7562 (2003).
    Article CAS Google Scholar
  28. Tachibana, M., Sugimoto, K., Fukushima, T. & Shinkai, Y. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J. Biol. Chem. 276, 25309–25317 (2001).
    Article CAS Google Scholar
  29. Hattori, N. et al. Epigenetic control of mouse Oct-4 gene expression in embryonic stem cells and trophoblast stem cells. J. Biol. Chem. 279, 17063–17069 (2004).
    Article CAS Google Scholar
  30. Fuks, F., Hurd, P. J., Deplus, R. & Kouzarides, T. The DNA methyltransferases associate with HP1 and the SUV39H1 histone methyltransferase. Nucleic Acids Res. 31, 2305–2312 (2003).
    Article CAS Google Scholar

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