Interaction between β-catenin and HIF-1 promotes cellular adaptation to hypoxia (original) (raw)

• van de Wetering, M. et al. The β-catenin/TCF-4 complex imposes a crypt progenitor phenotype on colorectal cancer cells. Cell 111, 241–250 (2002).
  Article CAS Google Scholar
• Korinek, V. et al. Constitutive transcriptional activation by a β-catenin–Tcf complex in APC−/− colon carcinoma. Science 275, 1784–1787 (1997).
  Article CAS Google Scholar
• Morin, P. J. et al. Activation of β-catenin–Tcf signaling in colon cancer by mutations in β-catenin or APC. Science 275, 1787–1790 (1997).
  Article CAS Google Scholar
• Carmeliet, P. et al. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis. Nature 394, 485–490 (1998).
  Article CAS Google Scholar
• Harris, A. L. Hypoxia — a key regulatory factor in tumour growth. Nature Rev. Cancer 2, 38–47 (2002).
  Article CAS Google Scholar
• Reya, T. & Clevers, H. Wnt signalling in stem cells and cancer. Nature 434, 843–850 (2005).
  Article CAS Google Scholar
• van de Wetering, M. et al. Armadillo coactivates transcription driven by the product of the Drosophila segment polarity gene dTCF. Cell 88, 789–799 (1997).
  Article CAS Google Scholar
• He, T. C. et al. Identification of c-MYC as a target of the APC pathway. Science 281, 1509–1512 (1998).
  Article CAS Google Scholar
• Hockel, M. & Vaupel, P. Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects. J. Natl Cancer Inst. 93, 266–276 (2001).
  Article CAS Google Scholar
• Maxwell, P. H. et al. Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth. Proc. Natl Acad. Sci. USA 94, 8104–8109 (1997).
  Article CAS Google Scholar
• Wang, G. L., Jiang, B. H., Rue, E. A. & Semenza, G. L. Hypoxia-inducible factor-1 is a basic-Helix-Loop-Helix-PAS heterodimer regulated by cellular O2 Tension. Proc. Natl Acad. Sci. USA 92, 5510–5514 (1995).
  Article CAS Google Scholar
• Semenza, G. L. Targeting HIF-1 for cancer therapy. Nature Rev. Cancer 3, 721–732 (2003).
  Article CAS Google Scholar
• Lal, A. et al. Transcriptional response to hypoxia in human tumors. J. Natl Cancer Inst. 93, 1337–1343 (2001).
  Article CAS Google Scholar
• Rosin-Arbesfeld, R., Cliffe, A., Brabletz, T. & Bienz, M. Nuclear export of the APC tumour suppressor controls β-catenin function in transcription. EMBO J. 22, 1101–1113 (2003).
  Article CAS Google Scholar
• Jaakkola, P. et al. Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation. Science 292, 468–472 (2001).
  Article CAS Google Scholar
• Mosimann, C., Hausmann, G. & Basler, K. Parafibromin/Hyrax activates Wnt/Wg target gene transcription by direct association with β-catenin/Armadillo. Cell 125, 327–341 (2006).
  Article CAS Google Scholar
• Kaidi, A., Qualtrough, D., Williams, A. C. & Paraskeva, C. Direct transcriptional up-regulation of cyclooxygenase-2 by hypoxia-inducible factor (HIF)-1 promotes colorectal tumor cell survival and enhances HIF-1 transcriptional activity during hypoxia. Cancer Res. 66, 6683–6691 (2006).
  Article CAS Google Scholar
• van de Wetering, M. et al. Specific inhibition of gene expression using a stably integrated, inducible small-interfering-RNA vector. EMBO Rep. 4, 609–615 (2003).
  Article CAS Google Scholar
• Zhong, H. et al. Overexpression of hypoxia-inducible factor 1 α in common human cancers and their metastases. Cancer Res. 59, 5830–5835 (1999).
  CAS PubMed Google Scholar
• Vaupel, P., Thews, O., Kelleher, D. K. & Hoeckel, M. Current status of knowledge and critical issues in tumor oxygenation. Results from 25 years research in tumor pathophysiology. Adv. Exp. Med. Biol. 454, 591–602 (1998).
  Article CAS Google Scholar
• Goethals, L. et al. Hypoxia in human colorectal adenocarcinoma: comparison between extrinsic and potential intrinsic hypoxia markers. Int. J Radiat. Oncol. Biol. Phys. 65, 246–254 (2006).
  Article CAS Google Scholar
• Goda, N. et al. Hypoxia-inducible factor 1α is essential for cell cycle arrest during hypoxia. Mol. Cell Biol. 23, 359–369 (2003).
  Article CAS Google Scholar
• Kim, J. H. et al. Transcriptional regulation of a metastasis suppressor gene by Tip60 and β-catenin complexes. Nature 434, 921–926 (2005).
  Article CAS Google Scholar
• Essers, M. A. et al. Functional interaction between β-catenin and FOXO in oxidative stress signaling. Science 308, 1181–1184 (2005).
  Article CAS Google Scholar
• Giles, R. H. et al. Interplay between VHL/HIF1α and Wnt/β-catenin pathways during colorectal tumorigenesis. Oncogene 25, 3065–3070 (2006).
  Article CAS Google Scholar
• Iyer, N. V. et al. Cellular and developmental control of O2 homeostasis by hypoxia-inducible factor 1 α. Genes Dev 12, 149–162 (1998).
  Article CAS Google Scholar
• Maretto, S. et al. Mapping Wnt/β-catenin signaling during mouse development and in colorectal tumors. Proc. Natl Acad. Sci. USA 100, 3299–3304 (2003).
  Article CAS Google Scholar
• Chell, S. D. et al. Increased EP4 receptor expression in colorectal cancer progression promotes cell growth and anchorage independence. Cancer Res. 66, 3106–3113 (2006).
  Article CAS Google Scholar
• Elder, D. J., Hague, A., Hicks, D. J. & Paraskeva, C. Differential growth inhibition by the aspirin metabolite salicylate in human colorectal tumor cell lines: enhanced apoptosis in carcinoma and in vitro-transformed adenoma relative to adenoma relative to adenoma cell lines. Cancer Res. 56, 2273–2276 (1996).
  CAS PubMed Google Scholar
• Essafi, A. et al. Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells. Oncogene 24, 2317–2329 (2005).
  Article CAS Google Scholar