Rab27a and Rab27b control different steps of the exosome secretion pathway (original) (raw)

• Thery, C., Zitvogel, L. & Amigorena, S. Exosomes: composition, biogenesis and function. Nature Rev. Immunol. 2, 569–579 (2002).
  Article CAS Google Scholar
• Fevrier, B. & Raposo, G. Exosomes: endosomal-derived vesicles shipping extracellular messages. Curr. Opin. Cell Biol. 16, 415–421 (2004).
  Article CAS Google Scholar
• Johnstone, R. M. Exosomes biological significance: a concise review. Blood Cells Mol. Dis. 36, 315–321 (2006).
  Article CAS Google Scholar
• Lakkaraju, A. & Rodriguez-Boulan, E. Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol. 18, 199–209 (2008).
  Article CAS Google Scholar
• Raposo, G. et al. B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183, 1161–1172 (1996).
  Article CAS Google Scholar
• Zitvogel, L. et al. Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nature Med. 4, 594–600 (1998).
  Article CAS Google Scholar
• Thery, C. et al. Indirect activation of naive CD4+ T cells by dendritic cell-derived exosomes. Nature Immunol. 3, 1156–1162 (2002).
  Article CAS Google Scholar
• Wiley, R. D. & Gummuluru, S. Immature dendritic cell-derived exosomes can mediate HIV-1 trans infection. Proc. Natl Acad. Sci. USA 103, 738–743 (2006).
  Article CAS Google Scholar
• Fevrier, B. et al. Cells release prions in association with exosomes. Proc. Natl Acad. Sci. USA 101, 9683–9688 (2004).
  Article CAS Google Scholar
• Rajendran, L. et al. Alzheimer's disease β-amyloid peptides are released in association with exosomes. Proc. Natl Acad. Sci. USA 103, 11172–11177 (2006).
  Article CAS Google Scholar
• Wolfers, J. et al. Tumor-derived exosomes are a source of shared tumor rejection antigens for CTL cross-priming. Nature Med. 7, 297–303 (2001).
  Article CAS Google Scholar
• Iero, M. et al. Tumour-released exosomes and their implications in cancer immunity. Cell Death Differ. 15, 80–88 (2008).
  Article CAS Google Scholar
• Zeelenberg, I. S. et al. Targeting tumor antigens to secreted membrane vesicles in vivo induces efficient antitumor immune responses. Cancer Res. 68, 1228–1235 (2008).
  Article CAS Google Scholar
• Futter, C. E., Collinson, L. M., Backer, J. M. & Hopkins, C. R. Human VPS34 is required for internal vesicle formation within multivesicular endosomes. J. Cell Biol. 155, 1251–1264 (2001).
  Article CAS Google Scholar
• Pan, B. T., Teng, K., Wu, C., Adam, M. & Johnstone, R. M. Electron. microscopic evidence for externalization of the transferrin receptor in vesicular form in sheep reticulocytes. J. Cell Biol. 101, 942–948 (1985).
  Article CAS Google Scholar
• Booth, A. M. et al. Exosomes and HIV Gag bud from endosome-like domains of the T cell plasma membrane. J. Cell Biol. 172, 923–935 (2006).
  Article CAS Google Scholar
• Zerial, M. & McBride, H. Rab proteins as membrane organizers. Nature Rev. Mol. Cell Biol. 2, 107–117 (2001).
  Article CAS Google Scholar
• Seabra, M. C., Mules, E. H. & Hume, A. N. Rab GTPases, intracellular traffic and disease. Trends Mol. Med. 8, 23–30 (2002).
  Article CAS Google Scholar
• Ali, B. R. & Seabra, M. C. Targeting of Rab GTPases to cellular membranes. Biochem. Soc. Trans. 33, 652–656 (2005).
  Article CAS Google Scholar
• Escola, J. M. et al. Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J. Biol. Chem. 273, 20121–20127 (1998).
  Article CAS Google Scholar
• Morelli, A. E. et al. Endocytosis, intracellular sorting, and processing of exosomes by dendritic cells. Blood 104, 3257–3266 (2004).
  Article CAS Google Scholar
• Thery, C. et al. Proteomic analysis of dendritic cell-derived exosomes: a secreted subcellular compartment distinct from apoptotic vesicles. J. Immunol. 166, 7309–7318 (2001).
  Article CAS Google Scholar
• Ramalho, J. S. et al. Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene. BMC Genet. 2, 2 (2001).
  Article CAS Google Scholar
• Thery, C., Amigorena, S., Raposo, G. & Clayton, A. Isolation and characterization of exosomes from cell culture supernatants and biological fluids. Curr. Protoc. Cell Biol. Chapter 3, Unit 3 22 (2006).
• Desnos, C. et al. Myosin va mediates docking of secretory granules at the plasma membrane. J. Neurosci. 27, 10636–10645 (2007).
  Article CAS Google Scholar
• Huet, S. et al. Analysis of transient behavior in complex trajectories: application to secretory vesicle dynamics. Biophys. J. 91, 3542–3559 (2006).
  Article CAS Google Scholar
• Nofal, S., Becherer, U., Hof, D., Matti, U. & Rettig, J. Primed vesicles can be distinguished from docked vesicles by analyzing their mobility. J. Neurosci. 27, 1386–1395 (2007).
  Article CAS Google Scholar
• Beraud-Dufour, S. & Balch, W. A journey through the exocytic pathway. J. Cell Sci. 115, 1779–1780 (2002).
  PubMed Google Scholar
• Pereira-Leal, J. B. & Seabra, M. C. Evolution of the Rab family of small GTP-binding proteins. J. Mol. Biol. 313, 889–901 (2001).
  Article CAS Google Scholar
• Buschow, S. I. et al. MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic 10, 1528–1542 (2009).
  Article CAS Google Scholar
• Desnos, C. et al. Rab27A and its effector MyRIP link secretory granules to F-actin and control their motion towards release sites. J. Cell Biol. 163, 559–570 (2003).
  Article CAS Google Scholar
• Chen, X. et al. Rab27b localizes to zymogen granules and regulates pancreatic acinar exocytosis. Biochem. Biophys. Res. Commun. 323, 1157–1162 (2004).
  Article CAS Google Scholar
• Imai, A., Yoshie, S., Nashida, T., Shimomura, H. & Fukuda, M. The small GTPase Rab27B regulates amylase release from rat parotid acinar cells. J. Cell Sci. 117, 1945–1953 (2004).
  Article CAS Google Scholar
• Mizuno, K. et al. Rab27b regulates mast cell granule dynamics and secretion. Traffic 8, 883–892 (2007).
  Article CAS Google Scholar
• Tolmachova, T., Abrink, M., Futter, C. E., Authi, K. S. & Seabra, M. C. Rab27b regulates number and secretion of platelet dense granules. Proc. Natl Acad. Sci. USA 104, 5872–5877 (2007).
  Article CAS Google Scholar
• Stinchcombe, J. C. et al. Rab27a is required for regulated secretion in cytotoxic T lymphocytes. J. Cell Biol. 152, 825–834 (2001).
  Article CAS Google Scholar
• Barral, D. C. et al. Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome. J. Clin. Invest. 110, 247–257 (2002).
  Article CAS Google Scholar
• Strom, M., Hume, A. N., Tarafder, A. K., Barkagianni, E. & Seabra, M. C. A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport. J. Biol. Chem. 277, 25423–25430 (2002).
  Article CAS Google Scholar
• Seabra, M. C. & Coudrier, E. Rab GTPases and myosin motors in organelle motility. Traffic 5, 393–399 (2004).
  Article CAS Google Scholar
• Savina, A., Vidal, M. & Colombo, M. I. The exosome pathway in K562 cells is regulated by Rab11. J. Cell Sci. 115, 2505–2515 (2002).
  CAS PubMed Google Scholar
• Kondo, H. et al. Constitutive GDP/GTP exchange and secretion-dependent GTP hydrolysis activity for Rab27 in platelets. J. Biol. Chem. 281, 28657–28665 (2006).
  Article CAS Google Scholar
• Stumptner-Cuvelette, P. et al. HIV-1 Nef impairs MHC class II antigen presentation and surface expression. Proc. Natl Acad. Sci. USA 98, 12144–12149 (2001).
  Article CAS Google Scholar
• Hume, A. N. et al. Rab27a regulates the peripheral distribution of melanosomes in melanocytes. J. Cell Biol. 152, 795–808 (2001).
  Article CAS Google Scholar
• Blott, E. J., Bossi, G., Clark, R., Zvelebil, M. & Griffiths, G. M. Fas ligand is targeted to secretory lysosomes via a proline-rich domain in its cytoplasmic tail. J. Cell Sci. 114, 2405–2416 (2001).
  CAS PubMed Google Scholar
• Fukuda, M., Kanno, E., Saegusa, C., Ogata, Y. & Kuroda, T. S. Slp4-a/granuphilin-a regulates dense-core vesicle exocytosis in PC12 cells. J. Biol. Chem. 277, 39673–39678 (2002).
  Article CAS Google Scholar
• Shu, X., Shaner, N. C., Yarbrough, C. A., Tsien, R. Y. & Remington, S. J. Novel chromophores and buried charges control color in mFruits. Biochemistry 45, 9639–9647 (2006).
  Article CAS Google Scholar
• Moffat, J. et al. A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. Cell 124, 1283–1298 (2006).
  Article CAS Google Scholar
• Racine, V. et al. Visualization and quantification of vesicle trafficking on a three-dimensional cytoskeleton network in living cells. J. Microsc. 225, 214–228 (2007).
  Article Google Scholar
• Steyer, J. A. & Almers, W. Tracking single secretory granules in live chromaffin cells by evanescent-field fluorescence microscopy. Biophys. J. 76, 2262–2271 (1999).
  Article CAS Google Scholar