Interleukin-12 suppresses ultraviolet radiation-induced apoptosis by inducing DNA repair (original) (raw)

• Murphy, G., Young, A. R., Wulf, H. C., Kulms, D. & Schwarz T. The molecular determinants of sunburn cell formation. Exp. Dermatol. 10, 155–160 (2001).
  Article CAS PubMed Google Scholar
• Ziegler, A. et al. Sunburn and p53 in the onset of skin cancer. Nature 372, 773–776 (1994).
  Article CAS PubMed Google Scholar
• Kulms, D. et al. Nuclear and cell membrane effects contribute independently to the induction of apoptosis in human cells exposed to UVB radiation. Proc. Natl Acad. Sci. USA 96, 7974–7979 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Stege, H. et al. Enzyme plus light therapy to repair DNA damage in ultraviolet-B-irradiated human skin. Proc. Natl Acad. Sci. USA 97, 1790–1795 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Aragane, Y. et al. Ultraviolet light induces apoptosis via direct activation of CD95 (Fas/APO-1) independently of its ligand CD95L. J. Cell. Biol. 140, 171–182 (1998).
  Article CAS PubMed PubMed Central Google Scholar
• Rehemtulla, A., Hamilton, C. A., Chinnaiyan, A. M. & Dixit, V. M. Ultraviolet radiation-induced apoptosis is mediated by activation of CD-95 (Fas/APO-1). J. Biol. Chem. 272, 25783–25786 (1997).
  Article CAS PubMed Google Scholar
• Sheikh, M. S., Antinore, M. J., Huang, Y. & Fornace, A. J. Jr. Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumour necrosis factor receptor 1. Oncogene 17, 2555–2563 (1998).
  Article CAS PubMed Google Scholar
• Schwarz, A. et al. UVB induced apoptosis of keratinocytes. Evidence for partial involvement of tumour necrosis factor α in the formation of sunburn cells. J. Invest. Dermatol. 104, 922–927 (1995).
  Article CAS PubMed Google Scholar
• Hill, L. L. et al. Fas ligand: a sensor for DNA damage critical in skin cancer etiology. Science 285, 898–900 (1999).
  Article CAS PubMed Google Scholar
• Leverkus, M., Yaar, M. & Gilchrest, B. A. Fas/Fas ligand interaction contributes to UV-induced apoptosis in human keratinocytes. Exp. Cell. Res. 232, 255–262 (1997).
  Article CAS PubMed Google Scholar
• Gloster, H. M. & Brodland, D. G. The epidemiology of skin cancer. Dermatol. Surg. 22, 217–226 (1996).
  PubMed Google Scholar
• Kothny-Wilkes et al. Interleukin-1 protects transformed keratinocytes from TRAIL-induced apoptosis. J. Biol. Chem. 273, 29247–29253 (1998).
  Article CAS PubMed Google Scholar
• Kothny-Wilkes, G., Kulms, D., Luger, T. A., Kubin, M. & Schwarz, T. Interleukin-1 protects transformed keratinocytes from tumour necrosis factor-related apoptosis-inducing ligand- and CD95-induced apoptosis but not from ultraviolet radiation-induced apoptosis. J. Biol. Chem. 274, 28916–28921 (1999).
  Article CAS PubMed Google Scholar
• Luger, T. A. & Schwarz, T. Effects of UV-light on cytokines and neuroendocrine hormones. In Photoimmunology (eds Elmets, C. & Krutmann, J.) 55–76 (1995).
  Google Scholar
• Patrick, M. H. Studies on thymine-derived UV photoproducts in DNA I. Formation and biological role of pyrimidine adducts in DNA. Photochem. Photobiol. 25, 357–372 (1977).
  Article CAS PubMed Google Scholar
• Aragane, Y. et al. IL-12 is expressed and released by human keratinocytes and epidermoid carcinoma cell lines. J. Immunol. 153, 5366–5372 (1994).
  CAS PubMed Google Scholar
• Koch, F. et al. High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10. J. Exp. Med. 184, 741–746 (1996).
  Article CAS PubMed Google Scholar
• Magram, J. et al. IL-12-deficient mice are defective in IFN gamma production and type 1 cytokine responses. Immunity 4, 471–481 (1996).
  Article CAS PubMed Google Scholar
• de Laat, W. L., Jaspers, N. G. & Hoeijmakers, J. H. Molecular mechanism of nucleotide excision repair. Genes Dev. 13, 768–785 (1999).
  Article CAS PubMed Google Scholar
• Rünger, T. M., Möller, K., Jung, T. & Dekant, B. DNA damage formation, DNA repair, and survival after exposure of DNA repair-proficient and nucleotide excision repair-deficient human lymphoblasts to UVA1 and UVB. Int. J. Radiat. Biol. 76, 789–797 (2000).
  Article PubMed Google Scholar
• Fairbairn, D. W., Olive, P. L. & O' Neill, K. L. The comet assay: a comprehensive review. Mutat. Res. 339; 37–59 (1995).
  Article CAS PubMed Google Scholar
• Arlett, C. F. et al. Hypersensitivity of human lymphocytes to UV-B and solar irradiation. Cancer Res. 53, 609–614 (1993).
  CAS PubMed Google Scholar
• Green, M. H. et al. UV-C sensitivity of unstimulated and stimulated human lymphocytes from normal and xeroderma pigmentosum donors in the comet assay: a potential diagnostic technique. Mutat. Res. 273, 137–144 (1992).
  Article CAS PubMed Google Scholar
• de Vries, A. et al. Increased susceptibility to ultraviolet-B and carcinogens of mice lacking the DNA excision repair gene XPA. Nature 377, 169–173 (1995).
  Article CAS PubMed Google Scholar
• van Oosten, M. et al. Differential role of transcription-coupled repair in UVB-induced G2 arrest and apoptosis in mouse epidermis. Proc. Natl Acad. Sci. USA 97, 11268–11273 (2000).
  Article CAS PubMed PubMed Central Google Scholar
• Kraemer, K. H., Lee, M. M., Andrews, A. D. & Lambert, W. C. The role of sunlight and DNA repair in melanoma and nonmelanoma skin cancer. The xeroderma pigmentosum paradigm. Arch. Dermatol. 130, 1018–1021 (1994).
  Article CAS PubMed Google Scholar
• Simon, M. M. et al. Heat shock protein 70 overexpression affects the response to ultraviolet light in murine fibroblasts. J. Clin. Invest. 95, 926–933 (1995).
  Article CAS PubMed PubMed Central Google Scholar
• Duckett, C. S. et al. Human IAP-like protein regulates programmed cell death downstream of bcl-xL and cytochrome c. Mol. Cell. Biol. 18, 608–615 (1998)
  Article CAS PubMed PubMed Central Google Scholar
• Wright, S. C., Wang, H., Wei, Q. S., Kinder, D. H. & Larrick, J. W. Bcl-2-mediated resistance to apoptosis is associated with glutathione-induced inhibition of AP24 activation of nuclear DNA fragmentation. Cancer Res. 58, 5570–5576 (1998).
  CAS PubMed Google Scholar
• O'Donovan, A., Davies, A. A., Moggs, J. G., West, S. C. & Wood, R. D. XPG endonuclease makes the 3' incision in human DNA nucleotide excision repair. Nature. 371, 432–435 (1994).
  Article CAS PubMed Google Scholar
• Mu, D., Hsu, D. S. & Sancar, A. Reaction mechanism of human DNA repair excision nuclease. J. Biol. Chem. 271, 8285–8294 (1996).
  Article CAS PubMed Google Scholar
• de Laat, W. L., Jaspers, N. G. & Hoeijmakers, J. H. DNA-binding polarity of human replication protein A positions nucleases in nucleotide excision repair. Genes Dev. 13, 768–785 (1999).
  Article CAS PubMed Google Scholar
• Kenny, M. K., Schlegel, U., Furneaux, H. & Hurwitz, J. The role of human single-stranded DNA binding protein and its individual subunits in simian virus 40 DNA replication. J. Biol. Chem. 265, 7693–700 (1990).
  CAS PubMed Google Scholar
• Zernik-Kobak, M., Vasunia, K., Connelly, M., Anderson, C. W. & Dixon, K. Sites of UV-induced phosphorylation of the p34 subunit of replication protein A from HeLa cells. J. Biol. Chem. 272, 23896–23904 (1997).
  Article CAS PubMed Google Scholar
• Hwang, B. J. & Chu, G. Purification and characterization of a human protein that binds to damaged DNA. Biochemistry 32, 1657–1666 (1993).
  Article CAS PubMed Google Scholar
• Hwang, B. J., Ford, J. M., Hanawalt, P. C. & Chu, G. Expression of the p48 xeroderma pigmentosum gene is p53-dependent and is involved in global genomic repair. Proc. Natl Acad. Sci. USA 96, 424–428 (1999).
  Article CAS PubMed PubMed Central Google Scholar
• Hoeijmakers, J. H. Genome maintenance mechanisms for preventing cancer. Nature 411, 366–374 (2001).
  Article CAS PubMed Google Scholar
• Yarosh, D. et al. Localization of liposomes containing a DNA repair enzyme in murine skin. J. Invest. Dermatol. 103, 461–468 (1994).
  Article CAS PubMed Google Scholar
• Yarosh, D. et al. Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice. Cancer Res. 52, 4227–4231 (1992).
  CAS PubMed Google Scholar
• Wolf, P., Cox, P., Yarosh, D. B. & Kripke, M. L. Sunscreens and T4N5 liposomes differ in their ability to protect against ultraviolet-induced sunburn cell formation, alterations of dendritic epidermal cells, and local suppression of contact hypersensitivity. J. Invest. Dermatol. 104, 287–292 (1995).
  Article CAS PubMed Google Scholar
• Eller, M. S., Maeda, T., Magnoni, C., Atwal, D. & Gilchrest, B. A. Enhancement of DNA repair in human skin cells by thymidine dinucleotides: evidence for a p53-mediated mammalian SOS response. Proc. Natl Acad. Sci. USA 94, 12627–12632. (1997).
  Article CAS PubMed PubMed Central Google Scholar
• Lehman, T. A. et al. p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14, 833–839 (1993).
  Article CAS PubMed Google Scholar
• Trinchieri, G. Interleukin-12 and its role in the generation of Th1 cells. Immunol. Today 14, 335–338 (1993).
  Article CAS PubMed Google Scholar
• Schwarz, A. et al. Interleukin-12 prevents UVB-induced local immunosuppression and overcomes UVB-induced tolerance. J. Invest. Dermatol. 106, 1187–1191 (1996).
  Article CAS PubMed Google Scholar
• Rivas, J. M. & Ullrich, S. E. Systemic suppression of DTH by supernatants from UV-irradiated keratinocytes: an essential role for IL-10. J. Immunol. 148, 3133–3139 (1992).
  Google Scholar
• Nishigori, C. et al. Evidence that DNA damage triggers interleukin 10 cytokine production in UV-irradiated murine keratinocytes. Proc. Natl Acad. Sci. USA 93, 10354–10359 (1996).
  Article CAS PubMed PubMed Central Google Scholar
• Schmitt, D. A., Walterscheid, J. P. & Ullrich, S. E. Reversal of ultraviolet radiation-induced immune suppression by recombinant interleukin-12: suppression of cytokine production. Immunology 101, 90–96 (2000).
  Article CAS PubMed PubMed Central Google Scholar