An allosteric potentiator of M4 mAChR modulates hippocampal synaptic transmission (original) (raw)

References

  1. Brown, T. & Zador, A. in The Synaptic Organization of the Brain (ed. Shepherd, G.M.) 346–388 (Oxford UP, New York, 1990).
    Google Scholar
  2. Drachman, D.A. & Leavitt, J. Human memory and the cholinergic system. A relationship to aging? Arch. Neurol. 30, 113–121 (1974).
    Article CAS Google Scholar
  3. Bartus, R.T., Dean, R.L., III, Beer, B. & Lippa, A.S. The cholinergic hypothesis of geriatric memory dysfunction. Science 217, 408–414 (1982).
    Article CAS Google Scholar
  4. Fibiger, H.C. Cholinergic mechanisms in learning, memory and dementia: a review of recent evidence. Trends Neurosci. 14, 220–223 (1991).
    Article CAS Google Scholar
  5. Cooper, J.D. & Sofroniew, M.V. Increased vulnerability of septal cholinergic neurons to partial loss of target neurons in aged rats. Neuroscience 75, 29–35 (1996).
    Article CAS Google Scholar
  6. Eglen, R.M., Choppin, A., Dillon, M.P. & Hegde, S. Muscarinic receptor ligands and their therapeutic potential. Curr. Opin. Chem. Biol. 3, 426–432 (1999).
    Article CAS Google Scholar
  7. Katzenschlager, R., Sampaio, C., Costa, J. & Lees, A. Anticholinergics for symptomatic management of Parkinson's disease. Cochrane Database Syst. Rev. 2, CD003735 (2003).
    Google Scholar
  8. Bymaster, F.P. et al. Role of specific muscarinic receptor subtypes in cholinergic parasympathomimetic responses, in vivo phosphoinositide hydrolysis, and pilocarpine-induced seizure activity. Eur. J. Neurosci. 17, 1403–1410 (2003).
    Article Google Scholar
  9. Hartvig, P., Gillberg, P.G., Gordh, T., Jr. & Post, C. Cholinergic mechanisms in pain and analgesia. Trends Pharmacol. Sci. Suppl.: 75–79 (1989).
  10. Davis, K.L. et al. A double-blind, placebo-controlled multicenter study of tacrine for Alzheimer's disease. The Tacrine Collaborative Study Group. N. Engl. J. Med. 327, 1253–1259 (1992).
    Article CAS Google Scholar
  11. Rogers, S.L., Farlow, M.R., Doody, R.S., Mohs, R. & Friedhoff, L.T. A 24-week, double-blind, placebo-controlled trial of donepezil in patients with Alzheimer's disease. Donepezil Study Group. Neurology 50, 136–145 (1998).
    Article CAS Google Scholar
  12. Raskind, M.A., Cyrus, P.A., Ruzicka, B.B. & Gulanski, B.I. The effects of metrifonate on the cognitive, behavioral, and functional performance of Alzheimer's disease patients. Metrifonate Study Group. J. Clin. Psychiatry 60, 318–325 (1999).
    Article CAS Google Scholar
  13. Wilkinson, D. & Murray, J. Galantamine: a randomized, double-blind, dose comparison in patients with Alzheimer's disease. Int. J. Geriatr. Psychiatry 16, 852–857 (2001).
    Article CAS Google Scholar
  14. Kaufer, D.I., Catt, K.E., Lopez, O.L. & DeKosky, S.T. Dementia with Lewy bodies: response of delirium-like features to donepezil. Neurology 51, 1512 (1998).
    Article CAS Google Scholar
  15. Feldman, H. Treating Alzheimer's disease with cholinesterase inhibitors: what have we learned so far? Int. Psychogeriatr. 14 (suppl. 1): 3–5 (2002).
    Article Google Scholar
  16. Rösler, M. The efficacy of cholinesterase inhibitors in treating the behavioural symptoms of dementia. Int. J. Clin. Pract. Suppl. 127, 20–36 (2002).
    Google Scholar
  17. Bullock, R. & Cameron, A. Rivastigmine for the treatment of dementia and visual hallucinations associated with Parkinson's disease: a case series. Curr. Med. Res. Opin. 18, 258–264 (2002).
    Article CAS Google Scholar
  18. Mirza, N.R., Peters, D. & Sparks, R.G. Xanomeline and the antipsychotic potential of muscarinic receptor subtype selective agonists. CNS Drug Rev. 9, 159–186 (2003).
    Article CAS Google Scholar
  19. Rouse, S.T., Marino, M.J., Potter, L.T., Conn, P.J. & Levey, A.I. Muscarinic receptor subtypes involved in hippocampal circuits. Life Sci. 64, 501–509 (1999).
    Article CAS Google Scholar
  20. Marino, M.J., Rouse, S.T., Levey, A.I., Potter, L.T. & Conn, P.J. Activation of the genetically defined m1 muscarinic receptor potentiates N-methyl-D-aspartate (NMDA) receptor currents in hippocampal pyramidal cells. Proc. Natl. Acad. Sci. USA 95, 11465–11470 (1998).
    Article CAS Google Scholar
  21. Rouse, S.T., Hamilton, S.E., Potter, L.T., Nathanson, N.M. & Conn, P.J. Muscarinic-induced modulation of potassium conductances is unchanged in mouse hippocampal pyramidal cells that lack functional M1 receptors. Neurosci. Lett. 278, 61–64 (2000).
    Article CAS Google Scholar
  22. Bymaster, F.P., McKinzie, D.L., Felder, C.C. & Wess, J. Use of M1–M5 muscarinic receptor knockout mice as novel tools to delineate the physiological roles of the muscarinic cholinergic system. Neurochem. Res. 28, 437–442 (2003).
    Article CAS Google Scholar
  23. Okamoto, H. et al. Muscarinic agonist potencies at three different effector systems linked to the M(2) or M(3) receptor in longitudinal smooth muscle of guinea-pig small intestine. Br. J. Pharmacol. 135, 1765–1775 (2002).
    Article CAS Google Scholar
  24. Messer, W.S., Jr. The utility of muscarinic agonists in the treatment of Alzheimer's disease. J. Mol. Neurosci. 19, 187–193 (2002).
    Article CAS Google Scholar
  25. Caulfield, M.P. & Birdsall, N.J. International Union of Pharmacology. XVII. Classification of muscarinic acetylcholine receptors. Pharmacol. Rev. 50, 279–290 (1998).
    CAS PubMed Google Scholar
  26. Felder, C.C., Bymaster, F.P., Ward, J. & DeLapp, N. Therapeutic opportunities for muscarinic receptors in the central nervous system. J. Med. Chem. 43, 4333–4353 (2000).
    Article CAS Google Scholar
  27. Wess, J. Molecular biology of muscarinic acetylcholine receptors. Crit. Rev. Neurobiol. 10, 69–99 (1996).
    Article CAS Google Scholar
  28. O'Brien, J.A. et al. A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. Mol. Pharmacol. 64, 731–740 (2003).
    Article CAS Google Scholar
  29. Marino, M.J. et al. Allosteric modulation of group III metabotropic glutamate receptor 4: a potential approach to Parkinson's disease treatment. Proc. Natl. Acad. Sci. USA 100, 13668–13673 (2003).
    Article CAS Google Scholar
  30. Kinney, G.G. et al. A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. J. Pharmacol. Exp. Ther. 313, 199–206 (2005).
    Article CAS Google Scholar
  31. Galici, R. et al. Biphenyl-indanone A, a positive allosteric modulator of the metabotropic glutamate receptor subtype 2, has antipsychotic- and anxiolytic-like effects in mice. J. Pharmacol. Exp. Ther. 318, 173–185 (2006).
    Article CAS Google Scholar
  32. Lazareno, S., Gharagozloo, P., Kuonen, D., Popham, A. & Birdsall, N.J. Subtype-selective positive cooperative interactions between brucine analogues and acetylcholine at muscarinic receptors: radioligand binding studies. Mol. Pharmacol. 53, 573–589 (1998).
    Article CAS Google Scholar
  33. Lazareno, S., Dolezal, V., Popham, A. & Birdsall, N.J. Thiochrome enhances acetylcholine affinity at muscarinic M4 receptors: receptor subtype selectivity via cooperativity rather than affinity. Mol. Pharmacol. 65, 257–266 (2004).
    Article CAS Google Scholar
  34. Coward, P., Chan, S.D., Wada, H.G., Humphries, G.M. & Conklin, B.R. Chimeric G proteins allow a high-throughput signaling assay of Gi-coupled receptors. Anal. Biochem. 270, 242–248 (1999).
    Article CAS Google Scholar
  35. Christopoulos, A. & Kenakin, T. G protein-coupled receptor allosterism and complexing. Pharmacol. Rev. 54, 323–374 (2002).
    Article CAS Google Scholar
  36. Bilkey, D.K. & Goddard, G.V. Medial septal facilitation of hippocampal granule cell activity is mediated by inhibition of inhibitory interneurones. Brain Res. 361, 99–106 (1985).
    Article CAS Google Scholar
  37. Sheridan, R.D. & Sutor, B. Presynaptic M1 muscarinic cholinoceptors mediate inhibition of excitatory synaptic transmission in the hippocampus in vitro. Neurosci. Lett. 108, 273–278 (1990).
    Article CAS Google Scholar
  38. Fernandez de Sevilla, D. & Buno, W. Presynaptic inhibition of Schaffer collateral synapses by stimulation of hippocampal cholinergic afferent fibres. Eur. J. Neurosci. 17, 555–558 (2003).
    Article Google Scholar
  39. Valentino, R.J. & Dingledine, R. Presynaptic inhibitory effect of acetylcholine in the hippocampus. J. Neurosci. 1, 784–792 (1981).
    Article CAS Google Scholar
  40. Qian, J. & Saggau, P. Presynaptic inhibition of synaptic transmission in the rat hippocampus by activation of muscarinic receptors: involvement of presynaptic calcium influx. Br. J. Pharmacol. 122, 511–519 (1997).
    Article CAS Google Scholar
  41. Pitler, T.A. & Alger, B.E. Depolarization-induced suppression of GABAergic inhibition in rat hippocampal pyramidal cells: G protein involvement in a presynaptic mechanism. Neuron 13, 1447–1455 (1994).
    Article CAS Google Scholar
  42. Gomeza, J. et al. Enhancement of D1 dopamine receptor-mediated locomotor stimulation in M(4) muscarinic acetylcholine receptor knockout mice. Proc. Natl. Acad. Sci. USA 96, 10483–10488 (1999).
    Article CAS Google Scholar
  43. Marino, M.J. & Conn, P.J. Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors. Curr. Opin. Pharmacol. 6, 98–102 (2006).
    Article CAS Google Scholar
  44. Dong, B.J. Cinacalcet: an oral calcimimetic agent for the management of hyperparathyroidism. Clin. Ther. 27, 1725–1751 (2005).
    Article CAS Google Scholar
  45. Levey, A.I., Edmunds, S.M., Hersch, S.M., Wiley, R.G. & Heilman, C.J. Light and electron microscopic study of m2 muscarinic acetylcholine receptor in the basal forebrain of the rat. J. Comp. Neurol. 351, 339–356 (1995).
    Article CAS Google Scholar
  46. Rouse, S.T., Edmunds, S.M., Yi, H., Gilmor, M.L. & Levey, A.I. Localization of M(2) muscarinic acetylcholine receptor protein in cholinergic and non-cholinergic terminals in rat hippocampus. Neurosci. Lett. 284, 182–186 (2000).
    Article CAS Google Scholar
  47. Ohno-Shosaku, T. et al. Postsynaptic M1 and M3 receptors are responsible for the muscarinic enhancement of retrograde endocannabinoid signalling in the hippocampus. Eur. J. Neurosci. 18, 109–116 (2003).
    Article Google Scholar

Download references