SAS-6 oligomerization: the key to the centriole? (original) (raw)

Nature Chemical Biology volume 7, pages 650–653 (2011)Cite this article

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Centrioles are among the most beautiful of biological structures. How their highly conserved nine-fold symmetry is generated is a question that has intrigued cell biologists for decades. Two recent structural studies provide the tantalizing suggestion that the self-organizing properties of the SAS-6 protein hold the answer.

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Figure 1: A schematic view of centrioles and the early stages of centriole duplication.

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Figure 2: The architecture and interactions of SAS-6.

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Figure 3: An illustration of the distinct SAS-6 oligomer models that can be derived from slightly different dimer orientations observed in the SAS-6 crystal structures.

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Authors and Affiliations

  1. Matthew A. Cottee, Jordan W. Raff, Susan M. Lea and Hélio Roque are at The Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.,
    Matthew A Cottee, Jordan W Raff, Susan M Lea & Hélio Roque

Authors

  1. Matthew A Cottee
  2. Jordan W Raff
  3. Susan M Lea
  4. Hélio Roque

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Correspondence toJordan W Raff.

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The authors declare no competing financial interests.

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Cottee, M., Raff, J., Lea, S. et al. SAS-6 oligomerization: the key to the centriole?.Nat Chem Biol 7, 650–653 (2011). https://doi.org/10.1038/nchembio.660

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