Mycobactin-mediated iron acquisition within macrophages (original) (raw)

References

1. Flo, T.H. et al. Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature 432, 917–921 (2004).
   Article CAS Google Scholar
2. Ferreras, J.A., Ryu, J.S., Lello, F.D., Tan, D.S. & Quadri, L.E.N. Small-molecule inhibition of siderophore biosynthesis in Mycobacterium tuberculosis and Yersinia pestis. Nat. Chem. Bio. 1, 29–32 (2005).
   Article CAS Google Scholar
3. Fluckinger, M., Hass, H., Merschak, P., Glasgow, B.J. & Redl, B. Human tear lipocalin exhibits antimicrobial activity by scavenging microbial siderophores. Antimicrob. Agents Chemother. 48, 3367–3372 (2004).
   Article CAS Google Scholar
4. Pieters, J. Entry and survival of pathogenic mycobacteria in macrophages. Microbes Infect. 3, 249–255 (2001).
   Article CAS Google Scholar
5. Rhoades, E.R. & Ullrich, H.J. How to establish a lasting relationship with your host: lessons learned from Mycobacterium spp. Immunol. Cell Biol. 78, 301–310 (2000).
   Article CAS Google Scholar
6. Schaible, U.E. & Kaufmann, S.H.E. Iron and microbial infection. Nat. Rev. Microbiol. 2, 946–953 (2004).
   Article CAS Google Scholar
7. Albrecht-Gary, A.M. & Crumbliss, A.L. Coordination chemistry of siderophores: thermodynamics and kinetics of iron chelation and release. Met. Ions Biol. Syst. 35, 239–327 (1998).
   CAS PubMed Google Scholar
8. Ratledge, C. & Dover, L.G. Iron metabolism in pathogenic bacteria. Annu. Rev. Microbiol. 54, 881–941 (2000).
   Article CAS Google Scholar
9. Melo, R.C., D'Avila, H., Fabrino, D.L., Almeida, P.E. & Bozza, P.T. Macrophage lipid body induction by Chagas disease in vivo: putative intracellular domains for eicosanoid formation during infection. Tissue Cell 35, 59–67 (2003).
   Article CAS Google Scholar
10. Yu, W. et al. Co-compartmentalization of MAP kinases and cytosolic phospholipase A(2) at cytoplasmic arachidonate-rich lipid bodies. Am. J. Pathol. 152, 759–769 (1998).
    CAS PubMed PubMed Central Google Scholar
11. Burke, B. & Lewis, C.E. The Macrophage (Oxford University Press, Oxford, UK, 2002).
    Google Scholar
12. Torti, S.V. et al. The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene. J. Biol. Chem. 263, 12638–12644 (1988).
    CAS PubMed Google Scholar
13. Byrd, T.F. & Horwitz, M.A. Regulation of transferrin receptor expression and ferritin content in human mononuclear phagocytes. Coordinate upregulation by iron transferrin and downregulation by interferon gamma. J. Clin. Invest. 91, 969–976 (1993).
    Article CAS Google Scholar
14. Weiss, G., Wachter, H. & Fuchs, D. Linkage of cell-mediated immunity to iron metabolism. Immunol. Today 16, 495–500 (1995).
    Article CAS Google Scholar
15. Vergne, A.F., Walz, A.J. & Miller, M.J. Iron chelators from mycobacteria (1954–1999) and potential therapeutic applications. Nat. Prod. Rep. 17, 99–116 (2000).
    Article CAS Google Scholar
16. Olakanmi, O., Schlesinger, L.S., Ahmed, A. & Britigan, B.E. Intraphagosomal Mycobacterium tuberculosis acquires iron from both extracellular transferrin and intracellular iron pools. Impact of interferon-gamma and hemochromatosis. J. Biol. Chem. 277, 49727–49734 (2002).
    Article CAS Google Scholar
17. Sun, H., Li, H.Y. & Sadler, P.J. Transferrin as a metal ion mediator. Chem. Rev. 99, 2817–2842 (1999).
    Article CAS Google Scholar
18. Fadeev, E.A., Luo, M. & Groves, J.T. Synthesis, structure, and molecular dynamics of gallium complexes of schizokinen and the amphiphilic siderophore acinetoferrin. J. Am. Chem. Soc. 126, 12065–12075 (2004).
    Article CAS Google Scholar
19. Murphy, D.J. The biogenesis and functions of lipid bodies in animals, plants and microorganisms. Prog. Lipid Res. 40, 325–438 (2001).
    Article CAS Google Scholar
20. Dvorak, A.M. et al. Lipid bodies: cytoplasmic organelles important to arachidonate metabolism in macrophages and mast cells. J. Immunol. 131, 2965–2976 (1983).
    CAS PubMed Google Scholar
21. De Voss, J.J. et al. The salicylate-derived mycobactin siderophores of Mycobacterium tuberculosis are essential for growth in macrophages. Proc. Natl. Acad. Sci. USA 97, 1252–1257 (2000).
    Article CAS Google Scholar
22. Xu, G., Martinez, J.S., Groves, J.T. & Butler, A. Membrane affinity of the amphiphilic marinobactin siderophores. J. Am. Chem. Soc. 124, 13408–13415 (2002).
    Article CAS Google Scholar
23. Luo, M., Fadeev, E.A. & Groves, J.T. Membrane dynamics of the amiphiphilic siderophore, acinetoferrin. J. Am. Chem. Soc. 127, 1726–1736 (2005).
    Article CAS Google Scholar
24. Moody, D.B. et al. T cell activation by lipopeptide antigens. Science 303, 527–531 (2004).
    Article CAS Google Scholar
25. Testa, U. et al. Iron up-modulates the expression of transferrin receptors during monocyte-macrophage maturation. J. Biol. Chem. 264, 13181–13187 (1989).
    CAS PubMed Google Scholar
26. Mulero, V. & Brock, J.H. Regulation of iron metabolism in murine J774 macrophages: role of nitric oxide-dependent and independent pathways following activation with gamma interferon and lipopolysaccharide. Blood 94, 2383–2389 (1999).
    CAS PubMed Google Scholar
27. Crosa, J.H. & Walsh, C.T. Genetics and assembly line enzymology of siderophore biosynthesis in bacteria. Microbiol. Mol. Biol. Rev. 66, 223–249 (2002).
    Article CAS Google Scholar
28. De Voss, J.J., Rutter, K., Schroeder, B.G. & Barry, C.E. Iron acquisition and metabolism by mycobacteria. J. Bacteriol. 181, 4443–4451 (1999).
    CAS PubMed PubMed Central Google Scholar
29. Ratledge, C. Iron, mycobacteria and tuberculosis. Tuberculosis (Edinb.) 84, 110–130 (2004).
    Article Google Scholar
30. Olakanmi, O., Britigan, B.E. & Schlesinger, L.S. Gallium disrupts iron metabolism of mycobacteria residing within human macrophages. Infect. Immun. 68, 5619–5627 (2000).
    Article CAS Google Scholar

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