Two Types of Ribosome in Mouse–Hamster Hybrid Cells (original) (raw)

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• Published: 10 March 1971

Nature New Biology volume 230, pages 52–54 (1971)Cite this article

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Abstract

ONLY mouse 28S ribosomal RNA (rRNA) can be detected in mouse-human hybrid cells1. Because these cells contain as many as thirty-five human chromosomes, including those believed to have ribosomal RNA genes, it has been suggested that the transcription of human ribosomal RNA genes may be repressed. Similar studies have not been performed with mouse-hamster hybrid cells because hamster and mouse 28S rRNAs have only a very small difference in their electro-phoretic mobilities2. We have now made use of the observation that free ribosomes (not engaged in translation) from hamster cells form dimers in conditions where mouse free ribosomes remain as monomers3 to determine whether mouse-hamster hybrid cells contain free ribosomes as monomers, dimers or as both.

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References

1. Eliceiri, G. L., and Green, H., J. Mol. Biol., 41, 253 (1969).
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2. Eliceiri, G. L., and Green, H., Biochim. Biophys. Acta, 199, 543 (1970).
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Authors and Affiliations

1. Ontario Cancer Institute, and Department of Medical Biophysics, University of Toronto, Toronto
   C. P. STANNERS
2. Department of Pathology, St Louis University School of Medicine, St Louis, Missouri, 63104
   G. L. ELICEIRI
3. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts
   H. GREEN

Authors

1. C. P. STANNERS
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2. G. L. ELICEIRI
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3. H. GREEN
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STANNERS, C., ELICEIRI, G. & GREEN, H. Two Types of Ribosome in Mouse–Hamster Hybrid Cells.Nature New Biology 230, 52–54 (1971). https://doi.org/10.1038/newbio230052a0

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• Received: 18 January 1971
• Issue Date: 10 March 1971
• DOI: https://doi.org/10.1038/newbio230052a0

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