Biosynthesis of J-Chain in Mouse IgA and IgM (original) (raw)

Nature New Biology volume 236, pages 9–11 (1972) Cite this article

Abstract

RECENT evidence1,2 suggests that the polymeric immunoglobulins, IgM, serum IgA and secretory IgA, but not IgG or monomeric serum IgA contain a third polypeptide chain, the J-chain, of molecular weight about 23,0001 or 26,0002. Each polymeric molecule irrespective of the number of monomeric (H2L2) subunits, is thought to contain only one molecule of J-chain. It is distinguishable from light chain by its amino-acid composition, tryptic peptide map and fast electrophoretic mobility on alkaline-urea-polyacrylamide gels1,2, but J-chains isolated from IgM and secretory IgA are indistinguishable by these criteria2.

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Authors and Affiliations

  1. National Institute for Medical Research, Mill Hill, London, NW7 1AA
    R. M. E. PARKHOUSE

Authors

  1. R. M. E. PARKHOUSE

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PARKHOUSE, R. Biosynthesis of J-Chain in Mouse IgA and IgM.Nature New Biology 236, 9–11 (1972). https://doi.org/10.1038/newbio236009a0

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