Common sequence variants on 20q11.22 confer melanoma susceptibility (original) (raw)

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Acknowledgements

This work was supported by the National Cancer Institute (NCI) of the US National Institutes of Health (NIH) (CA88363, CA83115), the National Health and Medical Research Council of Australia (NHMRC) (380385, 389892, 496675, 402761), the Cancer Councils New South Wales, Victoria and Queensland, the Cancer Institute New South Wales, the Melanoma Research Foundation (MRF) and a charitable contribution from F. Najafi. N.K.H. and G.W.M. are supported by the NHMRC Fellowships scheme and J.L.H. is an Australia Fellow of the NHMRC. S.M. and K.M.B. are recipients of Career Development Awards from the NHMRC (496674) and MRF, respectively. K.M.B. and J.M.T. are supported by the NCI/NIH (respectively, CA109544 and CA083115; and CA109544). D.A.S. is supported by the US National Heart, Lung, and Blood Institute of the NIH (HL086528). B.K.A. is supported by the University of Sydney Medical Foundation. A.E.C. is supported by an NHMRC postdoctoral fellowship. The authors are grateful to M. Huentelman and S. Szelinger for technical assistance. The AMFS and Q-MEGA gratefully acknowledge all of their participants, the hard work of all its research interviewers and examiners, and C. Agha-Hamilton for managing the AMFS biospecimens. Q-MEGA thanks A. Baxter, M. de Nooyer, I. Gardner, D. Statham, B. Haddon, J. Palmer, B. Castellano, L. Bardsley, D. Smyth and H. Beeby for their input into project management, sample processing and database development.

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Author notes

1. Kevin M Brown and Stuart MacGregor: These authors contributed equally to this work.

Authors and Affiliations

1. Integrated Cancer Genomics Division, The Translational Genomics Research Institute, Phoenix, 85028, Arizona, USA
   Kevin M Brown & Kelly Iyadurai
2. The Population Studies and Genetics Division, Queensland Institute of Medical Research, Brisbane, 4029, Queensland, Australia
   Stuart MacGregor, Grant W Montgomery, Zhen Zhen Zhao, Anjali K Henders, Megan J Campbell, Mitchell Stark, Shane Thomas, David L Duffy, David Whiteman, Adele Green, Nicholas G Martin & Nicholas K Hayward
3. Neurogenomics Division, The Translational Genomics Research Institute, Phoenix, 85028, Arizona, USA
   David W Craig & Dietrich A Stephan
4. University of California Los Angeles, Los Angeles, 90095, California, USA
   Nils Homer
5. Westmead Institute of Cancer Research and Sydney Melanoma Unit, University of Sydney at Westmead Millennium Institute, Westmead, 2145, New South Wales, Australia
   Helen Schmid, Elizabeth A Holland, Richard F Kefford & Graham J Mann
6. Inherited Disease Research Branch, National Human Genome Research Institute, National Institutes of Health, Baltimore, 21224, Maryland, USA
   Elizabeth M Gillanders
7. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, School of Population Health, University of Melbourne, Melbourne, 3052, Victoria, Australia
   Judith A Maskiell, Anne E Cust & John L Hopper
8. Viertel Centre for Research in Cancer Control, The Cancer Council Queensland, Brisbane, 4004, Queensland, Australia
   Jodie Jetann, Megan Ferguson & Joanne F Aitken
9. Lund Cancer Center Department of Oncology, University Hospital, Lund, SE-22185, Sweden
   Håkan Olsson
10. Dermatology Department, Melanoma Unit, Hospital Clínic, Institut de Investigació Biomèdica August Pi Suñe, Universitat de Barcelona, Barcelona, 08036, Spain
    Susana Puig
11. Department of Oncology, Biology, and Genetics, University of Genova, Genova, 16132, Italy
    Paola Ghiorzo
12. Department of Oncology-Pathology, Karolinska Institute and Karolinska University Hospital, Solna, S-171 76, Stockholm, Sweden
    Johan Hansson
13. INSERM, U794, Fondation Jean-Dausset–CEPH, Paris, 75010, France
    Florence Demenais
14. Division of Cancer Epidemiology and Genetics, Genetic Epidemiology Branch, National Cancer Institute, Bethesda, 20892, Maryland, USA
    Alisa M Goldstein
15. Department of Dermatology, Leiden University Medical Center, Leiden, 2333 AL, The Netherlands
    Nelleke A Gruis
16. Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, 19104, Pennsylvania, USA
    David E Elder
17. Section of Epidemiology and Biostatistics, Leeds Institute of Molecular Medicine, University of Leeds, Leeds, LS9 7TF, UK
    Julia Newton Bishop
18. Cancer Epidemiology Centre, The Cancer Council Victoria, Carlton, 3053, Victoria, Australia
    Graham G Giles
19. School of Public Health, University of Sydney, Sydney, 2006, New South Wales, Australia
    Bruce K Armstrong
20. Genetic Basis of Human Disease Division, The Translational Genomics Research Institute, Phoenix, 85028, Arizona, USA
    Jeffrey M Trent
21. On behalf of the Lund Melanoma Group.,
    Håkan Olsson
22. On behalf of the International Melanoma Genetics Consortium (GenoMEL).,
    Håkan Olsson, Susana Puig, Paola Ghiorzo, Johan Hansson, Florence Demenais, Nelleke A Gruis, David E Elder & Julia Newton Bishop

Authors

1. Kevin M Brown
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2. Stuart MacGregor
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3. Grant W Montgomery
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4. David W Craig
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5. Zhen Zhen Zhao
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6. Kelly Iyadurai
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7. Anjali K Henders
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8. Nils Homer
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9. Megan J Campbell
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10. Mitchell Stark
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11. Shane Thomas
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12. Helen Schmid
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13. Elizabeth A Holland
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14. Elizabeth M Gillanders
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15. David L Duffy
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16. Judith A Maskiell
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17. Jodie Jetann
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18. Megan Ferguson
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19. Dietrich A Stephan
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20. Anne E Cust
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21. David Whiteman
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22. Adele Green
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23. Håkan Olsson
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24. Susana Puig
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25. Paola Ghiorzo
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26. Johan Hansson
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27. Florence Demenais
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28. Alisa M Goldstein
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29. Nelleke A Gruis
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30. David E Elder
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31. Julia Newton Bishop
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32. Richard F Kefford
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33. Graham G Giles
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34. Bruce K Armstrong
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35. Joanne F Aitken
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36. John L Hopper
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37. Nicholas G Martin
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38. Jeffrey M Trent
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39. Graham J Mann
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40. Nicholas K Hayward
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Corresponding author

Correspondence toStuart MacGregor.

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Brown, K., MacGregor, S., Montgomery, G. et al. Common sequence variants on 20q11.22 confer melanoma susceptibility.Nat Genet 40, 838–840 (2008). https://doi.org/10.1038/ng.163

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• Received: 06 March 2008
• Accepted: 30 April 2008
• Published: 18 May 2008
• Issue Date: July 2008
• DOI: https://doi.org/10.1038/ng.163