A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk (original) (raw)

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Acknowledgements

We are very grateful to the following: all individuals assessed in the study; colleagues at UK Clinical Genetics Centres and the National Cancer Research Network. Cancer Research UK provided principal funding for this study. Additional funding was provided by CORE, the European Union (CPRB LSHC-CT-2004-503465) and the Thomas Falknor Fund. P.B. was funded by Leukaemia Research and I.C. was in receipt of a clinical training fellowship from St. George's Hospital Medical School.

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Author notes

1. Peter Broderick, Luis Carvajal-Carmona, Alan M Pittman and Emily Webb: These authors contributed equally to this work.

Authors and Affiliations

1. Section of Cancer Genetics, Institute of Cancer Research, Sutton, SM2 5NG, UK
   Peter Broderick, Alan M Pittman, Emily Webb, Steven Lubbe, Kate Sullivan, Sarah Fielding, Jayaram Vijayakrishnan, Ian Chandler, Elli Papaemmanuil, Steven Penegar, Wendy Wood, Gabrielle Sellick, Mobshra Qureshi & Richard S Houlston
2. Molecular and Population Genetics Laboratory, London Research Institute, Cancer Research UK, London, WC2A 3PX, UK
   Luis Carvajal-Carmona, Kimberley Howarth, Andrew Rowan, Sarah Spain, Emma Jaeger, Zoe Kemp, Maggie Gorman, Ana Teixeira, Enric Domingo, Ella Barclay, Lynn Martin & Ian Tomlinson
3. Institute of Cancer, Bart's and the London Medical School, Queen Mary College, University of London, London, EC1M 6BQ, UK
   Luis Carvajal-Carmona & Ian Tomlinson
4. Department of Medical Genetics, St Mary's Hospital, Manchester, M13 OJH, UK
   Lynn Martin
5. Department of Medical Genetics, Birmingham Women's Hospital, Edgbaston, B15 2TG, Birmingham, UK
   Lynn Martin
6. Cancer and Immunogenetics Laboratory, Weatherall Institute for Molecular Medicine, Oxford University, Oxford, OX3 9DS, UK
   Oliver Sieber
7. Department of Clinical Pharmacology, Oxford University, Radcliffe Infirmary, Oxford, OX2 6HA, UK
   David Kerr
8. Birmingham Clinical Trials Unit, University of Birmingham, Birmingham, B15 2TT, UK
   Richard Gray
9. The Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, SW3 6JB, UK
   Julian Peto
10. Non-Communicable Disease Epidemiology Unit, London School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK
    Julian Peto
11. Institute of Cancer Research, Sutton, SM2 5NG, Surrey, UK
    Julian Peto
12. Bioinformatics and Biostatistics, London Research Institute, Cancer Research UK, London, WC2A 3PX, UK
    Jean-Baptiste Cazier

Authors

1. Peter Broderick
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2. Luis Carvajal-Carmona
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3. Alan M Pittman
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4. Emily Webb
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5. Kimberley Howarth
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6. Andrew Rowan
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7. Steven Lubbe
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8. Sarah Spain
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9. Kate Sullivan
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10. Sarah Fielding
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11. Emma Jaeger
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12. Jayaram Vijayakrishnan
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13. Zoe Kemp
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14. Maggie Gorman
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15. Ian Chandler
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16. Elli Papaemmanuil
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17. Steven Penegar
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18. Wendy Wood
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19. Gabrielle Sellick
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20. Mobshra Qureshi
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21. Ana Teixeira
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22. Enric Domingo
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23. Ella Barclay
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24. Lynn Martin
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25. Oliver Sieber
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26. David Kerr
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27. Richard Gray
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28. Julian Peto
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29. Jean-Baptiste Cazier
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30. Ian Tomlinson
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31. Richard S Houlston
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Consortia

members of the CORGI Consortium

Contributions

R.S.H. and I.T. designed the study and obtained financial support. R.S.H. and I.T. drafted the manuscript, with substantial contributions from E.W. and A.M.P. Z.K., W.W., E.B., S.P., E.P., D.K., R.G., J.P., R.S.H., I.T. and members of the CORGI Consortium (see Supplementary Note) developed patient and sample acquisition; W.W., S.P., E.B., M.G. and L.M. performed sample collection; P.B., K.G., S.S., S.L., K.S., J.V., M.Q. and S.F. performed sample preparation; S.L. performed microsatellite evaluation of tumors; P.B., Z.K., L.C.-C., A.M.P., S.S. and E.J. performed co-ordination of genotyping; P.B., L.C.-C., A.M.P., S.S., K.H., K.S., J.V. and S.F. performed genotyping; A.M.P. and S.L. performed re-sequencing and analysis of the SMAD7 locus; E.W. and J.-B.C. performed bioinformatics and statistical analyses; I.C. performed histology; and A.R. performed expression studies. All authors contributed to the final paper.

Corresponding authors

Correspondence toIan Tomlinson or Richard S Houlston.

Additional information

A full list of authors is provided in the Supplementary Note.

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Broderick, P., Carvajal-Carmona, L., Pittman, A. et al. A genome-wide association study shows that common alleles of SMAD7 influence colorectal cancer risk.Nat Genet 39, 1315–1317 (2007). https://doi.org/10.1038/ng.2007.18

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• Received: 31 July 2007
• Accepted: 18 September 2007
• Published: 14 October 2007
• Issue Date: November 2007
• DOI: https://doi.org/10.1038/ng.2007.18