Vitamin C improves the quality of somatic cell reprogramming (original) (raw)

Nature Genetics volume 44, pages 366–367 (2012)Cite this article

Subjects

The reprogramming of somatic cells to a pluripotent state is prone to errors that could hamper the use of this technology. A new study now shows that vitamin C enhances the quality of somatic cell reprogramming in mice, highlighting the possibility that further manipulation of culture conditions could improve this technology for regenerative medicine.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$259.00 per year

only $21.58 per issue

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: Potential mechanisms by which vitamin C influences reprogramming.

References

  1. Zhao, X.Y. et al. Nature 461, 86–90 (2009).
    Article CAS PubMed Google Scholar
  2. Kang, L., Wang, J., Zhang, Y., Kou, Z. & Gao, S. Cell Stem Cell 5, 135–138 (2009).
    Article CAS PubMed Google Scholar
  3. Stadtfeld, M. et al. Nat. Genet. 44, 398–405 (2012).
    Article CAS PubMed PubMed Central Google Scholar
  4. Frei, B. & Lawson, S. Proc. Natl. Acad. Sci. USA 105, 11037–11038 (2008).
    Article CAS PubMed PubMed Central Google Scholar
  5. Esteban, M.A. et al. Cell Stem Cell 6, 71–79 (2010).
    Article CAS PubMed Google Scholar
  6. Pera, M.F. Nature 471, 46–47 (2011).
    Article CAS PubMed Google Scholar
  7. Liu, L. et al. J. Biol. Chem. 285, 19483–19490 (2010).
    Article CAS PubMed PubMed Central Google Scholar
  8. Stadtfeld, M. et al. Nature 465, 175–181 (2010).
    Article CAS PubMed PubMed Central Google Scholar
  9. Prigione, A. et al. Stem Cells 29, 1338–1348 (2011).
    CAS PubMed Google Scholar
  10. Massip, L. et al. FASEB J. 24, 158–172 (2010).
    Article PubMed Google Scholar
  11. Wang, T. et al. Cell Stem Cell 9, 575–587 (2011).
    Article CAS PubMed Google Scholar
  12. Subramanyam, D. et al. Nat. Biotechnol. 29, 443–448 (2011).
    Article CAS PubMed PubMed Central Google Scholar
  13. Liao, B. et al. J. Biol. Chem. 286, 17359–17364 (2011).
    Article CAS PubMed PubMed Central Google Scholar
  14. Banito, A. & Gil, J. EMBO Rep. 11, 353–359 (2010).
    Article CAS PubMed PubMed Central Google Scholar
  15. Chung, T.L. et al. Stem Cells 28, 1848–1855 (2010).
    Article CAS PubMed Google Scholar

Download references

Author information

Authors and Affiliations

  1. Miguel A. Esteban and Duanqing Pei are in the Stem Cell and Cancer Biology Group at the Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.,
    Miguel A Esteban & Duanqing Pei

Authors

  1. Miguel A Esteban
  2. Duanqing Pei

Corresponding authors

Correspondence toMiguel A Esteban or Duanqing Pei.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

About this article

Cite this article

Esteban, M., Pei, D. Vitamin C improves the quality of somatic cell reprogramming.Nat Genet 44, 366–367 (2012). https://doi.org/10.1038/ng.2222

Download citation

This article is cited by