Common variants associated with plasma triglycerides and risk for coronary artery disease (original) (raw)

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Acknowledgements

We thank the Global Lipids Genetics Consortium for early access to the association results of the Metabochip study. S. Kathiresan is supported by a Research Scholar award from the Massachusetts General Hospital, the Howard Goodman Fellowship from Massachusetts General Hospital, the Donovan Family Foundation, R01HL107816 from the US National Institutes of Health and a grant from Fondation Leducq. R.D. is supported by a Banting Fellowship from the Canadian Institutes of Health Research. G.P. is supported by award T32HL007208 from the National Heart, Lung, and Blood Institute. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Heart, Lung, and Blood Institute or the US National Institutes of Health.

Author information

Author notes

1. Mark J Daly, Benjamin M Neale and Sekar Kathiresan: These authors jointly directed this work. Correspondence should be addressed to S. Kathiresan (skathiresan@partners.org), B.M.N. (bneale@broadinstitute.org) or M.J.D. (mjdaly@atgu.mgh.harvard.edu).
2. Mark J Daly, Benjamin M Neale and Sekar Kathiresan: These author contributed equally to this work.

Authors and Affiliations

1. Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA
   Ron Do, Chi Gao & Sekar Kathiresan
2. Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
   Ron Do, Chi Gao, Gina M Peloso, Richa Saxena, David Altshuler, Mark J Daly, Benjamin M Neale & Sekar Kathiresan
3. Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
   Ron Do, David Altshuler & Sekar Kathiresan
4. Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
   Ron Do, Chi Gao, Gina M Peloso, Tõnu Esko, Pierre Fontanillas, Cameron D Palmer, Sailaja Vedantam, Joel N Hirschhorn, David Altshuler, Mark J Daly, Benjamin M Neale & Sekar Kathiresan
5. Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan, USA
   Cristen J Willer
6. Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA
   Cristen J Willer & Ellen M Schmidt
7. Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA
   Cristen J Willer
8. Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
   Cristen J Willer, Sebanti Sengupta, Jin Chen, Jennifer L Bragg-Gresham, Anne U Jackson, Carlo Sidore, Tanya M Teslovich, Michael Boehnke & Goncalo R Abecasis
9. Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
   Gina M Peloso & L Adrienne Cupples
10. Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden
    Stefan Gustafsson, Andrea Ganna, Ci Song, Agneta Siegbahn & Erik Ingelsson
11. Science for Life Laboratory, Uppsala University, Uppsala, Sweden
    Stefan Gustafsson, Andrea Ganna, Ci Song & Erik Ingelsson
12. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Stavroula Kanoni, Deepti Gurdasani, Inês Barroso, Theodore Papamarkou, Cristina Pomilla, Kathleen Stirrups, Nicholas Wainwright, Elizabeth H Young, Samuli Ripatti, Manjinder S Sandhu & Panos Deloukas
13. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Andrea Ganna, Patrik K E Magnusson, Ci Song & Nancy L Pedersen
14. Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
    Martin L Buchkovich, Ying Wu & Karen L Mohlke
15. Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
    Samia Mora, Paul M Ridker & Daniel I Chasman
16. Division of Cardiovascular Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Samia Mora, Paul M Ridker & Daniel I Chasman
17. Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland
    Jacques S Beckmann
18. Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
    Jacques S Beckmann
19. Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
    Hsing-Yi Chang
20. Department of Epidemiology, Genetic Epidemiology Unit, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ayşe Demirkan, Aaron Isaacs & Cornelia M van Duijn
21. Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands
    Heleen M Den Hertog, Evita G Van den Herik & Peter J Koudstaal
22. Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
    Louise A Donnelly, Alex S F Doney, Andrew D Morris & Colin N A Palmer
23. Department of Specialities of Medicine, Cardiology, Geneva University Hospital, Geneva, Switzerland
    Georg B Ehret & François Mach
24. Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Georg B Ehret & Aravinda Chakravarti
25. Estonian Genome Center of the University of Tartu, Tartu, Estonia
    Tõnu Esko, Krista Fischer, Evelin Mihailov, Markus Perola & Andres Metspalu
26. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
    Tõnu Esko, Evelin Mihailov & Andres Metspalu
27. Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA
    Mary F Feitosa & Ingrid B Borecki
28. Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
    Teresa Ferreira, Cecilia M Lindgren, Mark I McCarthy & Erik Ingelsson
29. Centre for Population Health Sciences, University of Edinburgh, Edinburgh, UK
    Ross M Fraser, Jennifer L Bolton, Igor Rudan, Sarah H Wild, James F Wilson, Harry Campbell & Jackie F Price
30. Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK
    Daniel F Freitag, Deepti Gurdasani, Theodore Papamarkou, Cristina Pomilla, Nicholas Wainwright, Elizabeth H Young, John Danesh, Danish Saleheen & Manjinder S Sandhu
31. Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
    Kauko Heikkilä & Jaakko Kaprio
32. Centre For Paediatric Epidemiology and Biostatistics/Medical Research Council (MRC) Centre of Epidemiology for Child Health, University College London Institute of Child Health, London, UK
    Elina Hyppönen & Chris Power
33. Centre for Medical Systems Biology, Leiden, The Netherlands
    Aaron Isaacs & Cornelia M van Duijn
34. Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden
    Åsa Johansson & Ulf Gyllensten
35. Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden
    Åsa Johansson, Agneta Siegbahn & Lars Wallentin
36. Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Toby Johnson & Patricia B Munroe
37. Clinical Pharmacology, National Institute for Health Research (NIHR) Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK
    Toby Johnson & Patricia B Munroe
38. Biocenter Oulu, University of Oulu, Oulu, Finland
    Marika Kaakinen & Marjo-Riitta Järvelin
39. Institute of Health Sciences, University of Oulu, Oulu, Finland
    Marika Kaakinen, Paul Elliott & Marjo-Riitta Järvelin
40. Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
    Johannes Kettunen, Markus Perola, Ida Surakka, Aarno Palotie, Kaisa Silander, Jaakko Kaprio & Samuli Ripatti
41. Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland
    Johannes Kettunen, Markus Perola, Ida Surakka, Kaisa Silander & Samuli Ripatti
42. Department of Internal Medicine II–Cardiology, University of Ulm Medical Centre, Ulm, Germany
    Marcus E Kleber
43. Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Mannheim, Germany
    Marcus E Kleber & Winfried März
44. Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Xiaohui Li, Eric Kim & Jerome I Rotter
45. MRC Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
    Jian'an Luan, Claudia Langenberg, Ruth J F Loos, Ken K Ong, Jing Hua Zhao & Nicholas J Wareham
46. Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland
    Leo-Pekka Lyytikäinen & Terho Lehtimäki
47. Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland
    Leo-Pekka Lyytikäinen & Terho Lehtimäki
48. Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
    Massimo Mangino & Tim D Spector
49. Department of Medicine, Division of Endocrinology, Diabetes and Nutrition, University of Maryland, School of Medicine, Baltimore, Maryland, USA
    May E Montasser, Jeffrey R O'Connell, Braxton D Mitchell & Alan R Shuldiner
50. Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
    Martina Müller-Nurasyid, Ann-Kristin Petersen & Christian Gieger
51. Department of Medicine I, University Hospital Grosshadern, Ludwig Maximilians University of Munich, Munich, Germany
    Martina Müller-Nurasyid
52. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig Maximilians University of Munich, Munich, Germany
    Martina Müller-Nurasyid
53. Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
    Ilja M Nolte
54. Division of Endocrinology, Children's Hospital Boston, Boston, Massachusetts, USA
    Cameron D Palmer, Sailaja Vedantam & Joel N Hirschhorn
55. Division of Genetics, Program in Genomics, Children's Hospital Boston, Boston, Massachusetts, USA
    Cameron D Palmer, Sailaja Vedantam & Joel N Hirschhorn
56. Istituto di Ricerca Genetica e Biomedica, Consiglio Nazionale delle Ricerche, Monserrato, Italy
    Serena Sanna & Carlo Sidore
57. Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, Los Angeles, California, USA
    Susan K Service & Nelson B Freimer
58. Department of Epidemiology and Public Health, Genetic Epidemiology Group, University College London, London, UK
    Sonia Shah, Meena Kumari, Aroon Hingorani & Mika Kivimaki
59. Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hospital, Malmö, Sweden
    Dmitry Shungin & Paul W Franks
60. Department of Odontology, Umeå University, Umeå, Sweden
    Dmitry Shungin
61. Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden
    Dmitry Shungin & Paul W Franks
62. Dipartimento di Scienze Biomediche, Universita di Sassari, Sassari, Italy
    Carlo Sidore
63. Department of Medicine Solna, Atherosclerosis Research Unit, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Rona J Strawbridge & Anders Hamsten
64. Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden
    Rona J Strawbridge & Anders Hamsten
65. Clinical Research Branch, US National Institutes of Health, Baltimore, Maryland, USA
    Toshiko Tanaka & Luigi Ferrucci
66. deCODE Genetics/Amgen, Reykjavik, Iceland
    Gudmar Thorleifsson, Hilma Holm, Kari Stefansson & Unnur Thorsteinsdottir
67. Department of Genetics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Benjamin F Voight
68. Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA
    Benjamin F Voight
69. Human Genetics Center, University of Texas Health Science Center, School of Public Health, Houston, Texas, USA
    Kelly A Volcik & Eric Boerwinkle
70. HudsonAlpha Institute for Biotechnology, Huntsville, Alabama, USA
    Lindsay L Waite & Devin Absher
71. MRC Unit for Lifelong Health and Ageing, London, UK
    Andrew Wong, Ken K Ong & Diana Kuh
72. Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, UK
    Weihua Zhang, Paul Elliott, John C Chambers & Marjo-Riitta Järvelin
73. Ealing Hospital National Health Service (NHS) Trust, Middlesex, UK
    Weihua Zhang, John C Chambers & Jaspal S Kooner
74. Medical Research Council/Uganda Virus Research Institute, Uganda Research Unit on AIDS, Entebbe, Uganda
    Gershim Asiki, Pontiano Kaleebu, Rebecca N Nsubuga & Janet Seeley
75. University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
    Inês Barroso
76. NIHR Cambridge Biomedical Research Centre, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
    Inês Barroso
77. Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA
    Latonya F Been, Martha L Gravito & Dharambir K Sanghera
78. Genome Technology Branch, National Human Genome Research Institute, US National Institutes of Health, Bethesda, Maryland, USA
    Lori L Bonnycastle, Narisu Narisu, Amy J Swift & Francis S Collins
79. Department of Experimental Medicine, University of Milano-Bicocca, Monza, Italy
    Paolo Brambilla
80. MedStar Health Research Institute, Hyattsville, Maryland, USA
    Mary S Burnett & Stephen E Epstein
81. Research Centre on Public Health, University of Milano-Bicocca, Monza, Italy
    Giancarlo Cesana
82. Department of Dietetics-Nutrition, Harokopio University, Athens, Greece
    Maria Dimitriou & George Dedoussis
83. Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg, Germany
    Angela Döring & Christa Meisinger
84. Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg, Germany
    Angela Döring
85. MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, London, UK
    Paul Elliott & Marjo-Riitta Järvelin
86. The Laboratory in Mjodd, Reykjavik, Iceland
    Gudmundur Ingi Eyjolfsson
87. Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Bruna Gigante & Ulf de Faire
88. Department of Medicine, Division of Endocrinology, Diabetes and Metabolism, Cedars-Sinai Medical Center, Los Angeles, California, USA
    Mark O Goodarzi & Michelle R Jones
89. Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany
    Harald Grallert, Thomas Illig & Norman Klopp
90. Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
    Christopher J Groves & Mark I McCarthy
91. Department of Public Health and Clinical Medicine, Nutritional Research, Umeå University, Umeå, Sweden
    Göran Hallmans
92. Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland
    Anna-Liisa Hartikainen & Anneli Pouta
93. MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, UK
    Caroline Hayward
94. Laboratory of Neurogenetics, National Institute on Aging, Bethesda, Maryland, USA
    Dena Hernandez
95. Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy (Affiliated Institute of the University of Lübeck).,
    Andrew A Hicks & Peter P Pramstaller
96. Division of Endocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan
    Yi-Jen Hung
97. Hannover Unified Biobank, Hannover Medical School, Hannover, Germany
    Thomas Illig & Norman Klopp
98. Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands
    John J P Kastelein & G Kees Hovingh
99. Clinical Gerontology Unit, University of Cambridge, Cambridge, UK
    Kay-Tee Khaw
100. Kuopio Research Institute of Exercise Medicine, Kuopio, Finland
     Pirjo Komulainen, Timo A Lakka & Rainer Rauramaa
101. Department of Internal Medicine, Division of Endocrine and Metabolism, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan
     Shih-Yi Lin
102. Diabetes Prevention Unit, National Institute for Health and Welfare, Helsinki, Finland
     Jaana Lindström & Jaakko Tuomilehto
103. The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, New York, USA
     Ruth J F Loos
104. The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at Mount Sinai, New York, New York, USA
     Ruth J F Loos
105. The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York, New York, USA
     Ruth J F Loos
106. School of Social and Community Medicine, University of Bristol, Bristol, UK
     Wendy L McArdle
107. Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
     Gabrielle Müller
108. Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA
     Ramaiah Nagaraja
109. Department of Clinical Pharmacology, University of Tampere School of Medicine, Tampere, Finland
     Tuomo V M Nieminen
110. Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland
     Tuomo V M Nieminen
111. Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland
     Tuomo V M Nieminen
112. Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland
     Isleifur Olafsson
113. Department of Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
     Aarno Palotie
114. Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
     Aarno Palotie
115. Department of Statistical Sciences, University College London, London, UK
     Theodore Papamarkou
116. National Institute for Health and Welfare, Oulu, Finland
     Anneli Pouta & Marjo-Riitta Järvelin
117. Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, Translational Research Center, Philadelphia, Pennsylvania, USA
     Daniel J Rader & Muredach P Reilly
118. Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, Translational Research Center, Philadelphia, Pennsylvania, USA
     Daniel J Rader & Muredach P Reilly
119. Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands
     Fernando Rivadeneira, Andre G Uitterlinden & Albert Hofman
120. Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, The Netherlands
     Fernando Rivadeneira & Andre G Uitterlinden
121. Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Leiden, The Netherlands
     Fernando Rivadeneira, Andre G Uitterlinden & Albert Hofman
122. Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland
     Aimo Ruokonen
123. National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester, UK
     Nilesh Samani
124. Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
     Nilesh Samani
125. Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria
     Hubert Scharnagl & Winfried März
126. School of International Development, University of East Anglia, Norwich, UK
     Janet Seeley
127. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
     Alena Stančáková
128. INSERM UMRS 937, Pierre and Marie Curie University, Paris, France
     Laurence Tiret
129. Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
     L Joost van Pelt
130. LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
     L Joost van Pelt, Cisca Wijmenga & Bruce H R Wolffenbuttel
131. Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
     Cisca Wijmenga
132. Department of Biological Psychology, VU University, Amsterdam, The Netherlands
     Gonneke Willemsen & Dorret I Boomsma
133. Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway
     Tom Wilsgaard & Inger Njølstad
134. Department of Nutrition, University of North Carolina, Chapel Hill, North Carolina, USA
     Linda S Adair
135. Department of Epidemiology and Public Health, University of Strasbourg, Faculty of Medicine, Strasbourg, France
     Dominique Arveiler
136. Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
     Themistocles L Assimes & Thomas Quertermous
137. Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy
     Stefania Bandinelli
138. Department of Pathology, Chemical Pathology, University of the West Indies, Mona, Jamaica
     Franklyn Bennett
139. Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Lausanne, Switzerland
     Murielle Bochud & Pascal Bovet
140. Department of Internal Medicine, Division of Endocrinology and Diabetes, Ulm University Medical Centre, Ulm, Germany
     Bernhard O Boehm
141. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore.,
     Bernhard O Boehm
142. Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Dresden, Germany
     Stefan R Bornstein & Peter E H Schwarz
143. Ministry of Health, Victoria, Republic of Seychelles.,
     Pascal Bovet
144. Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland
     Michel Burnier
145. Imperial College Healthcare National Health Service (NHS) Trust, London, UK
     John C Chambers & Jaspal S Kooner
146. Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA
     Yii-Der Ida Chen
147. Department of Medicine, University of California, Los Angeles, Los Angeles, California, USA
     Yii-Der Ida Chen
148. Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois, USA.,
     Richard S Cooper & Bamidele O Tayo
149. Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines.,
     Alan B Feranil
150. Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France.,
     Jean Ferrières
151. Department of Psychiatry, University of California, Los Angeles, Los Angeles, California, USA
     Nelson B Freimer
152. Department of Clinical Sciences, Lund University, Malmö, Sweden
     Leif C Groop
153. Department of Medicine, Helsinki University Hospital, Helsinki, Finland
     Leif C Groop
154. Icelandic Heart Association, Kopavogur, Iceland.,
     Vilmundur Gudnason
155. Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden
     Anders Hamsten
156. Laboratory of Epidemiology, Demography and Biometry, National Institute on Ageing, Bethesda, Maryland, USA
     Tamara B Harris
157. Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan
     Chao Agnes Hsiung
158. Cardiovascular Genetics, British Heart Foundation Laboratories, Institute Cardiovascular Science, University College London, London, UK
     Steve E Humphries
159. Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA.,
     Steven C Hunt
160. Department of Public Health and General Practice, Nord-Trøndelag Health Study (HUNT) Research Centre, Norwegian University of Science and Technology, Levanger, Norway.,
     Kristian Hveem
161. Division of Research, Kaiser Permanente, Oakland, California, USA.,
     Carlos Iribarren
162. Unit of Primary Care, Oulu University Hospital, Oulu, Finland
     Marjo-Riitta Järvelin
163. Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland.,
     Antti Jula
164. Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland
     Mika Kähönen
165. Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland
     Jaakko Kaprio
166. Department of Medicine, Institute of Clinical Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland
     Antero Kesäniemi
167. National Heart and Lung Institute, Imperial College London, Hammersmith Hospital, London, UK
     Jaspal S Kooner
168. Children's Hospital Oakland Research Institute, Oakland, California, USA.,
     Ronald M Krauss
169. Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland
     Johanna Kuusisto & Markku Laakso
170. Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark.,
     Kirsten O Kyvik
171. Odense Patient Data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark.,
     Kirsten O Kyvik
172. Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland
     Timo A Lakka
173. Department of Medical Sciences, Uppsala University, Uppsala, Sweden
     Lars Lind, Agneta Siegbahn & Lars Wallentin
174. Queensland Institute of Medical Research, Royal Brisbane Hospital, Brisbane, Queensland, Australia.,
     Nicholas G Martin & John B Whitfield
175. Synlab Academy, Synlab Services, Mannheim, Germany
     Winfried März
176. Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Jamaica
     Colin A McKenzie
177. INSERM U872, Centre de Recherche des Cordeliers, Paris, France
     Pierre Meneton
178. Department of Medicine, Kuopio University Hospital, Kuopio, Finland
     Leena Moilanen
179. Department of Neurology, General Central Hospital, Bolzano, Italy
     Peter P Pramstaller
180. Department of Neurology, University of Lübeck, Lübeck, Germany
     Peter P Pramstaller
181. Departments of Medicine, Cardiovascular Health Research Unit, Epidemiology and Health Services, University of Washington, Seattle, Washington, USA
     Bruce M Psaty
182. Group Health Research Institute, Group Health Cooperative, Seattle, Washington, USA
     Bruce M Psaty
183. Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland
     Rainer Rauramaa
184. Center for Non-Communicable Diseases, Karachi, Pakistan
     Danish Saleheen
185. Department of Medicine, University of Pennsylvania, USA
     Danish Saleheen
186. Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland
     Veikko Salomaa
187. South Karelia Central Hospital, Lappeenranta, Finland
     Jouko Saramies
188. Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany
     Peter E H Schwarz
189. Department of Internal Medicine, Division of Endocrine and Metabolism, Taichung Veterans General Hospital, Taichung, Taiwan
     Wayne H-H Sheu
190. Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland, USA
     Alan R Shuldiner
191. Faculty of Medicine, University of Iceland, Reykjavík, Iceland
     Kari Stefansson & Unnur Thorsteinsdottir
192. Division of Population Health Sciences and Education, St. George's, University of London, London, UK
     David P Strachan
193. Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Milan, Italy
     Elena Tremoli
194. Centre for Vascular Prevention, Danube University Krems, Krems, Austria
     Jaakko Tuomilehto
195. King Abdulaziz University, Faculty of Medicine, Jeddah, Saudi Arabia
     Jaakko Tuomilehto
196. Red La Red Temática de Investigación Cooperativa en Enfermedades Cardiovasculares (RECAVA) Grupo RD06/0014/0015, Hospital Universitario La Paz, Madrid, Spain
     Jaakko Tuomilehto
197. Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland
     Matti Uusitupa
198. Research Unit, Kuopio University Hospital, Kuopio, Finland
     Matti Uusitupa
199. Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland
     Peter Vollenweider
200. Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands
     Bruce H R Wolffenbuttel
201. Department of Cardiovascular Epidemiology and Population Genetics, National Center for Cardiovascular Investigation, Madrid, Spain
     Jose M Ordovas
202. Madrid Institute for Advanced Studies (Instituto Madrileño de Estudios Avanzados)–Alimentación, Madrid, Spain
     Jose M Ordovas
203. Jean Mayer US Department of Agriculture Human Nutrition Research Center on Aging at Tufts University, Nutrition and Genomics Laboratory, Boston, Massachusetts, USA
     Jose M Ordovas
204. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
     Paul W Franks
205. Framingham Heart Study, Framingham, Massachusetts, USA
     L Adrienne Cupples
206. Center for Public Health Genomics, University of Virginia, Charlottesville, Virginia, USA
     Stephen S Rich & Benjamin M Neale
207. Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, Massachusetts, USA
     Mark J Daly

Authors

1. Ron Do
2. Cristen J Willer
3. Ellen M Schmidt
4. Sebanti Sengupta
5. Chi Gao
6. Gina M Peloso
7. Stefan Gustafsson
8. Stavroula Kanoni
9. Andrea Ganna
10. Jin Chen
11. Martin L Buchkovich
12. Samia Mora
13. Jacques S Beckmann
14. Jennifer L Bragg-Gresham
15. Hsing-Yi Chang
16. Ayşe Demirkan
17. Heleen M Den Hertog
18. Louise A Donnelly
19. Georg B Ehret
20. Tõnu Esko
21. Mary F Feitosa
22. Teresa Ferreira
23. Krista Fischer
24. Pierre Fontanillas
25. Ross M Fraser
26. Daniel F Freitag
27. Deepti Gurdasani
28. Kauko Heikkilä
29. Elina Hyppönen
30. Aaron Isaacs
31. Anne U Jackson
32. Åsa Johansson
33. Toby Johnson
34. Marika Kaakinen
35. Johannes Kettunen
36. Marcus E Kleber
37. Xiaohui Li
38. Jian'an Luan
39. Leo-Pekka Lyytikäinen
40. Patrik K E Magnusson
41. Massimo Mangino
42. Evelin Mihailov
43. May E Montasser
44. Martina Müller-Nurasyid
45. Ilja M Nolte
46. Jeffrey R O'Connell
47. Cameron D Palmer
48. Markus Perola
49. Ann-Kristin Petersen
50. Serena Sanna
51. Richa Saxena
52. Susan K Service
53. Sonia Shah
54. Dmitry Shungin
55. Carlo Sidore
56. Ci Song
57. Rona J Strawbridge
58. Ida Surakka
59. Toshiko Tanaka
60. Tanya M Teslovich
61. Gudmar Thorleifsson
62. Evita G Van den Herik
63. Benjamin F Voight
64. Kelly A Volcik
65. Lindsay L Waite
66. Andrew Wong
67. Ying Wu
68. Weihua Zhang
69. Devin Absher
70. Gershim Asiki
71. Inês Barroso
72. Latonya F Been
73. Jennifer L Bolton
74. Lori L Bonnycastle
75. Paolo Brambilla
76. Mary S Burnett
77. Giancarlo Cesana
78. Maria Dimitriou
79. Alex S F Doney
80. Angela Döring
81. Paul Elliott
82. Stephen E Epstein
83. Gudmundur Ingi Eyjolfsson
84. Bruna Gigante
85. Mark O Goodarzi
86. Harald Grallert
87. Martha L Gravito
88. Christopher J Groves
89. Göran Hallmans
90. Anna-Liisa Hartikainen
91. Caroline Hayward
92. Dena Hernandez
93. Andrew A Hicks
94. Hilma Holm
95. Yi-Jen Hung
96. Thomas Illig
97. Michelle R Jones
98. Pontiano Kaleebu
99. John J P Kastelein
100. Kay-Tee Khaw
101. Eric Kim
102. Norman Klopp
103. Pirjo Komulainen
104. Meena Kumari
105. Claudia Langenberg
106. Terho Lehtimäki
107. Shih-Yi Lin
108. Jaana Lindström
109. Ruth J F Loos
110. François Mach
111. Wendy L McArdle
112. Christa Meisinger
113. Braxton D Mitchell
114. Gabrielle Müller
115. Ramaiah Nagaraja
116. Narisu Narisu
117. Tuomo V M Nieminen
118. Rebecca N Nsubuga
119. Isleifur Olafsson
120. Ken K Ong
121. Aarno Palotie
122. Theodore Papamarkou
123. Cristina Pomilla
124. Anneli Pouta
125. Daniel J Rader
126. Muredach P Reilly
127. Paul M Ridker
128. Fernando Rivadeneira
129. Igor Rudan
130. Aimo Ruokonen
131. Nilesh Samani
132. Hubert Scharnagl
133. Janet Seeley
134. Kaisa Silander
135. Alena Stančáková
136. Kathleen Stirrups
137. Amy J Swift
138. Laurence Tiret
139. Andre G Uitterlinden
140. L Joost van Pelt
141. Sailaja Vedantam
142. Nicholas Wainwright
143. Cisca Wijmenga
144. Sarah H Wild
145. Gonneke Willemsen
146. Tom Wilsgaard
147. James F Wilson
148. Elizabeth H Young
149. Jing Hua Zhao
150. Linda S Adair
151. Dominique Arveiler
152. Themistocles L Assimes
153. Stefania Bandinelli
154. Franklyn Bennett
155. Murielle Bochud
156. Bernhard O Boehm
157. Dorret I Boomsma
158. Ingrid B Borecki
159. Stefan R Bornstein
160. Pascal Bovet
161. Michel Burnier
162. Harry Campbell
163. Aravinda Chakravarti
164. John C Chambers
165. Yii-Der Ida Chen
166. Francis S Collins
167. Richard S Cooper
168. John Danesh
169. George Dedoussis
170. Ulf de Faire
171. Alan B Feranil
172. Jean Ferrières
173. Luigi Ferrucci
174. Nelson B Freimer
175. Christian Gieger
176. Leif C Groop
177. Vilmundur Gudnason
178. Ulf Gyllensten
179. Anders Hamsten
180. Tamara B Harris
181. Aroon Hingorani
182. Joel N Hirschhorn
183. Albert Hofman
184. G Kees Hovingh
185. Chao Agnes Hsiung
186. Steve E Humphries
187. Steven C Hunt
188. Kristian Hveem
189. Carlos Iribarren
190. Marjo-Riitta Järvelin
191. Antti Jula
192. Mika Kähönen
193. Jaakko Kaprio
194. Antero Kesäniemi
195. Mika Kivimaki
196. Jaspal S Kooner
197. Peter J Koudstaal
198. Ronald M Krauss
199. Diana Kuh
200. Johanna Kuusisto
201. Kirsten O Kyvik
202. Markku Laakso
203. Timo A Lakka
204. Lars Lind
205. Cecilia M Lindgren
206. Nicholas G Martin
207. Winfried März
208. Mark I McCarthy
209. Colin A McKenzie
210. Pierre Meneton
211. Andres Metspalu
212. Leena Moilanen
213. Andrew D Morris
214. Patricia B Munroe
215. Inger Njølstad
216. Nancy L Pedersen
217. Chris Power
218. Peter P Pramstaller
219. Jackie F Price
220. Bruce M Psaty
221. Thomas Quertermous
222. Rainer Rauramaa
223. Danish Saleheen
224. Veikko Salomaa
225. Dharambir K Sanghera
226. Jouko Saramies
227. Peter E H Schwarz
228. Wayne H-H Sheu
229. Alan R Shuldiner
230. Agneta Siegbahn
231. Tim D Spector
232. Kari Stefansson
233. David P Strachan
234. Bamidele O Tayo
235. Elena Tremoli
236. Jaakko Tuomilehto
237. Matti Uusitupa
238. Cornelia M van Duijn
239. Peter Vollenweider
240. Lars Wallentin
241. Nicholas J Wareham
242. John B Whitfield
243. Bruce H R Wolffenbuttel
244. David Altshuler
245. Jose M Ordovas
246. Eric Boerwinkle
247. Colin N A Palmer
248. Unnur Thorsteinsdottir
249. Daniel I Chasman
250. Jerome I Rotter
251. Paul W Franks
252. Samuli Ripatti
253. L Adrienne Cupples
254. Manjinder S Sandhu
255. Stephen S Rich
256. Michael Boehnke
257. Panos Deloukas
258. Karen L Mohlke
259. Erik Ingelsson
260. Goncalo R Abecasis
261. Mark J Daly
262. Benjamin M Neale
263. Sekar Kathiresan

Contributions

R.D. carried out primary data analyses and prepared the supplementary information. R.D. and C. Gao prepared figures and tables. C.J.W., E.M.S., S. Sengupta, S.S.R. and G.R.A. contributed meta-analysis results. J.C. and M.L.B. performed bioinformatic analyses. R.D., M.J.D., B.M.N. and S. Kathiresan contributed to the design and conduct of the study. R.D., M.J.D., B.M.N. and S. Kathiresan wrote the manuscript.

All authors contributed to the research and reviewed the manuscript.

Design, management and coordination of contributing cohorts: (ADVANCE) T.L.A.; (AGES Reykjavik study) T.B.H. and V.G.; (AIDHS/SDS) D.K.S.; (AMC-PAS) P.D. and G.K.H.; (Amish GLGC) A.R.S.; (ARIC) E.B.; (B58C-WTCCC and B58C-T1DGC) D.P.S.; (B58C-Metabochip) C.M.L., C. Power and M.I.M.; (BLSA) L.F.; (BRIGHT) P.B.M.; (CARDIoGRAM) N.S.; (CHS) B.M.P. and J.I.R.; (CLHNS) A.B.F., K.L.M. and L.S.A.; (CoLaus) P.V.; (CROATIA-Vis) C.H. and I.R.; (deCODE) K. Stefansson and U.T.; (DIAGEN) P.E.H.S. and S.R.B.; (DILGOM) S.R.; (DPS) M.U.; (DR's EXTRA) R.R.; (EAS) J.F.P.; (EGCUT (Estonian Genome Center of the University of Tartu)) A.M.; (ELY) N.J.W.; (ENGAGE) N.B.F.; (EPIC) N.W. and K.-T.K.; (EPIC_N_OBSET GWAS) E.H.Y.; (ERF) C.M.v.D.; (ESS (Erasmus Stroke Study)) P.J.K.; (Family Heart Study (FHS)) I.B.B.; (FBPP) A.C., R.S.C. and S.C.H.; (FENLAND) R.J.F.L. and N.W.; (FIN-D2D 2007) A.K. and L.M.; (FINCAVAS) M. Kähönen; (Framingham) L.A.C., S. Kathiresan and J.M.O.; (FRISCII) A. Siegbahn and L.W.; (FUSION GWAS) K.L.M. and M. Boehnke; (FUSION stage 2) F.S.C., J.T. and J. Saramies; (GenomEUTwin) J.B.W., N.G.M., K.O.K., V.S., J. Kaprio, A. Jula, D.I.B., N.L.P. and T.D.S.; (GLACIER) P.W.F. and G.H.; (Go-DARTS) A.D.M. and C.N.A.P.; (GxE/Spanish Town) B.O.T., C.A.M., F.B., J.N.H. and R.S.C.; (HUNT2) K. Hveem; (IMPROVE) U.d.F., A. Hamsten, E.T. and S.E.H.; (InCHIANTI) S.B.; (KORAF4) C. Gieger; (LifeLines) B.H.R.W.; (LOLIPOP) J.S.K. and J.C.C.; (LURIC) B.O.B. and W.M.; (MDC) L.C.G., D. Altshuler and S. Kathiresan; (MEDSTAR) M.S.B. and S.E.E.; (METSIM) J. Kuusisto and M.L.; (MICROS) P.P.P.; (MORGAM) D. Arveiler and J.F.; (MRC/UVRI GPC GWAS) P. Kaleebu, G.A., J. Seeley and E.H.Y.; (MRC National Survey of Health and Development) D.K.; (NFBC1986) M.-R.J.; (NSPHS) U.G.; (ORCADES) H.C.; (PARC) Y.-D.I.C., R.M.K. and J.I.R.; (PennCath) D.J.R. and M.P.R.; (PIVUS) E.I. and L.L.; (PROMIS) J.D., P.D. and D. Saleheen; (Rotterdam Study) A. Hofman and A.G.U.; (SardiNIA) G.R.A.; (SCARFSHEEP) A. Hamsten and U.d.F.; (SEYCHELLES) M. Burnier, M. Bochud and P. Bovet; (SUVIMAX) P.M.; (Swedish Twin Registry) E.I. and N.L.P.; (TAICHI) T.L.A., Y.-D.I.C., C.A.H., T.Q., J.I.R. and W.H.-H.S.; (THISEAS) G.D. and P.D.; (Tromsø) I.N.; (TWINGENE) U.d.F. and E.I.; (ULSAM) E.I.; and (Whitehall II) A. Hingorani and M. Kivimaki.

Genotyping of contributing cohorts: (ADVANCE) D. Absher; (AIDHS/SDS) L.F.B. and M.L.G.; (AMC-PAS) P.D. and G.K.H.; (B58C-WTCCC and B58C-T1DGC) W.L.M.; (B58C-Metabochip) M.I.M.; (BLSA) D.H.; (BRIGHT) P.B.M.; (CHS) J.I.R.; (DIAGEN) N.N. and G.M.; (DILGOM) A. Palotie; (DR's EXTRA) T.A.L.; (EAS) J.F.W.; (EGCUT (Estonian Genome Center of the University of Tartu)) T.E.; (EPIC) P.D.; (EPIC_N_SUBCOH GWAS) I.B.; (ERF) C.M.v.D.; (ESS (Erasmus Stroke Study)) C.M.v.D.; (FBPP) A.C. and G.B.E.; (FENLAND) M.S.S.; (FIN-D2D 2007) A.J.S.; (FINCAVAS) T.L.; (Framingham) J.M.O.; (FUSION stage 2) L.L.B.; (GLACIER) I.B.; (Go-DARTS) C.J.G., C.N.A.P. and M.I.M.; (IMPROVE) A. Hamsten; (KORAF3) H.G. and T.I.; (KORAF4) N.K.; (LifeLines) C.W.; (LOLIPOP) J.S.K. and J.C.C.; (LURIC) M.E.K.; (MDC) B.F.V. and R.D.; (MICROS) A.A.H.; (MORGAM) L.T. and P. Brambilla; (MRC/UVRI GPC GWAS) M.S.S.; (MRC National Survey of Health and Development) A.W., D.K. and K.K.O.; (NFBC1986) A.-L.H., M.-R.J., M.I.M., P.E. and S.V.; (NSPHS and FRISCII) Å. Johansson; (ORCADES) H.C.; (PARC) M.O.G., M.R.J. and J.I.R.; (PIVUS) E.I. and L.L.; (PROMIS) P.D. and K. Stirrups; (Rotterdam Study) A.G.U. and F.R.; (SardiNIA) R.N.; (SCARFSHEEP) B.G. and R.J.S.; (SEYCHELLES) F.M. and G.B.E.; (Swedish Twin Registry) E.I. and N.L.P.; (TAICHI) D. Absher, T.L.A., E.K., T.Q. and L.L.W.; (THISEAS) P.D.; (TWINGENE) A. Hamsten and E.I.; (ULSAM) E.I.; (WGHS) S.M., D.I.C. and P.M.R.; and (Whitehall II) A. Hingorani, C.L., M. Kumari and M. Kivimaki.

Phenotype definition of contributing cohorts: (ADVANCE) C.I.; (AGES Reykjavik study) T.B.H. and V.G.; (AIDHS/SDS) L.F.B.; (AMC-PAS) J.J.P.K.; (Amish GLGC) A.R.S. and B.D.M.; (B58C-WTCCC and B58C-T1DGC) D.P.S.; (B58C-Metabochip) C. Power and E.H.; (BRIGHT) P.B.M.; (CHS) B.M.P.; (CoLaus) P.V.; (deCODE) G.I.E., H.H. and I.O.; (DIAGEN) G.M.; (DILGOM) K. Silander; (DPS) J. Lindström; (DR's EXTRA) P. Komulainen; (EAS) J.L.B.; (EGCUT (Estonian Genome Center of the University of Tartu)) A.M.; (EGCUT (Estonian Genome Center of the University of Tartu)) K.F.; (ERF and Rotterdam Study) A. Hofman; (ERF) C.M.v.D.; (ESS (Erasmus Stroke Study)) E.G.V.d.H., H.M.D.H. and P.J.K.; (FBPP) A.C., R.S.C. and S.C.H.; (FINCAVAS) T.V.M.N.; (Framingham) S. Kathiresan and J.M.O.; (GenomEUTwin: MZGWA) J.B.W.; (GenomEUTwin-FINRISK) V.S.; (GenomEUTwin-FINTWIN) J. Kaprio and K. Heikkilä; (GenomEUTwin-GENMETS) A. Jula; (GenomEUTwin-NLDTWIN) G.W.; (Go-DARTS) A.S.F.D., A.D.M., C.N.A.P. and L.A.D.; (GxE/Spanish Town) C.A.M. and F.B.; (IMPROVE) U.d.F., A. Hamsten and E.T.; (KORAF3) C.M.; (KORAF4) A. Döring; (LifeLines) L.J.v.P.; (LOLIPOP) J.S.K. and J.C.C.; (LURIC) H.S.; (MDC) L.C.G.; (METSIM) A. Stančáková; (MORGAM) G.C.; (MRC/UVRI GPC GWAS) R.N.N.; (MRC National Survey of Health and Development) D.K.; (NFBC1986) A.R., A.-L.H., A. Pouta and M.-R.J.; (NSPHS and FRISCII) Å. Johansson; (NSPHS) U.G.; (ORCADES) S.H.W.; (PARC) Y.-D.I.C. and R.M.K.; (PIVUS) E.I. and L.L.; (PROMIS) D.F.F.; (Rotterdam Study) A. Hofman; (SCARFSHEEP) U.d.F. and B.G.; (SEYCHELLES) M. Burnier, M. Bochud and P. Bovet; (Swedish Twin Registry) E.I. and N.L.P.; (TAICHI) H.-Y.C., C.A.H., Y.-J.H., E.K., S.-Y.L. and W.H.-H.S.; (THISEAS) G.D. and M.D.; (Tromsø) T.W.; (TWINGENE) U.d.F. and E.I.; (ULSAM) E.I.; (WGHS) P.M.R.; and (Whitehall II) M. Kumari.

Primary analysis from contributing cohorts: (ADVANCE) L.L.W.; (AIDHS/SDS) R.S.; (AMC-PAS) S. Kanoni; (Amish GLGC) J.R.O. and M.E.M.; (ARIC) K.A.V.; (B58C-Metabochip) C.M.L., E.H. and T.F.; (B58C-WTCCC and B58C-T1DGC) D.P.S.; (BLSA) T.T.; (BRIGHT) T.J.; (CLHNS) Y.W.; (CoLaus) J.S.B.; (deCODE) G.T.; (DIAGEN) A.U.J.; (DILGOM) M.P.; (EAS) R.M.F.; (DPS) A.U.J.; (DR'S EXTRA) A.U.J.; (EGCUT (Estonian Genome Center of the University of Tartu)) E.M., K.F. and T.E.; (ELY) D.G.; (EPIC) K. Stirrups and D.G.; (EPIC_N_OBSET GWAS) E.H.Y. and C.L.; (EPIC_N_SUBCOH GWAS) N.W.; (ERF) A.I.; (ESS (Erasmus Stroke Study)) C.M.v.D. and E.G.V.d.H.; (EUROSPAN) A. Demirkan; (Family Heart Study (FHS)) I.B.B. and M.F.F.; (FBPP) A.C. and G.B.E.; (FENLAND) T.P. and C. Pomilla; (FENLAND GWAS) J.H.Z. and J. Luan; (FIN-D2D 2007) A.U.J.; (FINCAVAS) L.-P.L.; (Framingham) L.A.C. and G.M.P.; (FRISCII and NSPHS) Å. Johansson; (FUSION stage 2) T.M.T.; (GenomEUTwin-FINRISK) J. Kettunen; (GenomEUTwin-FINTWIN) K. Heikkilä; (GenomEUTwin-GENMETS) I.S.; (GenomEUTwin-SWETWIN) P.K.E.M.; (GenomEUTwin-UK-TWINS) M.M.; (GLACIER) D. Shungin; (GLACIER) P.W.F.; (Go-DARTS) C.N.A.P. and L.A.D.; (GxE/Spanish Town) C.D.P.; (HUNT) A.U.J.; (IMPROVE) R.J.S.; (InCHIANTI) T.T.; (KORAF3) M.M.-N.; (KORAF4) A.-K.P.; (LifeLines) I.M.N.; (LOLIPOP) W.Z.; (LURIC) M.E.K.; (MDC) B.F.V.; (MDC) P.F. and R.D.; (METSIM) A.U.J.; (MRC/UVRI GPC GWAS) R.N.N.; (MRC National Survey of Health and Development) A.W. and J. Luan; (NFBC1986) M. Kaakinen, I.S. and S.K.S.; (NSPHS and FRISCII) Å. Johansson; (PARC) X.L.; (PIVUS) C. Song and E.I.; (PROMIS) J.D., D.F.F. and K. Stirrups; (Rotterdam Study) A.I.; (SardiNIA) C. Sidore, J.L.B.-G. and S. Sanna; (SCARFSHEEP) R.J.S.; (SEYCHELLES) G.B.E. and M. Bochud; (SUVIMAX) T.J.; (Swedish Twin Registry) C. Song and E.I.; (TAICHI) D. Absher, T.L.A., H.-Y.C., M.O.G., C.A.H., T.Q. and L.L.W.; (THISEAS) S. Kanoni; (Tromsø) A.U.J.; (TWINGENE) A.G. and E.I.; (ULSAM) C. Song, E.I. and S.G.; (WGHS) D.I.C.; and (Whitehall II) S. Shah.

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Correspondence toMark J Daly, Benjamin M Neale or Sekar Kathiresan.

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Competing interests

B.M.P. serves on the Data and Safety Monitoring Board of a clinical trial funded by the manufacturer (Zoll), and he serves on the Steering Committee of the Yale Open-Data Project funded by the Medtronic. P.V. received an unrestricted grant from GlaxoSmithKline to build the CoLaus study. G.T., H.H., A.K., K. Stefansson and U.T. are employees of deCODE Genetics/Amgen, a biotechnology company. I.B. and spouse own stock in GlaxoSmithKline and Incyte, Ltd. S. Kathiresan serves on scientific advisory boards for Merck, Celera, American Genomics and Catabasis. He has received unrestricted research grants from Merck and Pfizer.

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Do, R., Willer, C., Schmidt, E. et al. Common variants associated with plasma triglycerides and risk for coronary artery disease.Nat Genet 45, 1345–1352 (2013). https://doi.org/10.1038/ng.2795

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• Received: 20 February 2013
• Accepted: 13 September 2013
• Published: 06 October 2013
• Issue date: November 2013
• DOI: https://doi.org/10.1038/ng.2795