Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation (original) (raw)

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Acknowledgements

This work was supported by grants from the Chinese High-Tech (863) Program (2012AA02A201 and 2012AA02A208), the Guangdong Innovative Research Team Program (2009010016), the State Key Development Program for Basic Research of China–973 Program (2011CB809203 and 2014CB745200) and the Shenzhen Municipal Government of China (JC201005260191A, CXB201108250096A, ZDSY20120615154448514 and BGI20100001).

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Author notes

1. Guangwu Guo, Xiaojuan Sun, Chao Chen, Song Wu, Peide Huang, Zesong Li and Michael Dean: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Urological Surgery, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
   Guangwu Guo, Xiaojuan Sun, Song Wu, Zesong Li, Yi Huang, Aifa Tang, Shiqiang Zhang, Mingfu Qi, Liangfu Xie, Xiangjun Zou, Li Xing, Zhaojie Lv, Hongbin Mei, Hao Chen & Zhiming Cai
2. BGI-Shenzhen, Shenzhen, China
   Guangwu Guo, Chao Chen, Peide Huang, Wenlong Jia, Quan Zhou, Zuoquan Yang, Pengfei Song, Rui Ye, Zhao Lin, Shengqing Wan, Fan Fan, Xueda Hu, Shengjie Gao, Zhibo Gao, Yuan Yu, Lin Li, Xiaodong Fang, Jie Yang, Xin Zhao, Fang Zhang, Yingrui Li, Xiuqing Zhang, Jian Wang, Huanming Yang & Jun Wang
3. National-Regional Key Technology Engineering Laboratory for Clinical Application of Cancer Genomics, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
   Xiaojuan Sun, Song Wu, Zesong Li, Yi Huang, Aifa Tang, Shiqiang Zhang, Mingfu Qi, Liangfu Xie, Xiangjun Zou, Li Xing, Zhaojie Lv, Hongbin Mei, Hao Chen & Zhiming Cai
4. Shenzhen Engineering Laboratory of Tumor Clinical Immune Gene Therapy, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
   Xiaojuan Sun, Song Wu, Zesong Li, Yi Huang, Aifa Tang, Shiqiang Zhang, Mingfu Qi, Liangfu Xie, Xiangjun Zou, Li Xing, Zhaojie Lv, Hongbin Mei, Hao Chen & Zhiming Cai
5. Shenzhen Key Laboratory of Genitourinary Tumor, Shenzhen Second People's Hospital, The First Affiliated Hospital of Shenzhen University, Shenzhen, China
   Xiaojuan Sun, Song Wu, Zesong Li, Yi Huang, Aifa Tang, Shiqiang Zhang, Mingfu Qi, Liangfu Xie, Xiangjun Zou, Li Xing, Zhaojie Lv, Hongbin Mei, Hao Chen & Zhiming Cai
6. Institute of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China
   Song Wu
7. Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China
   Song Wu & Fangjian Zhou
8. Cancer and Inflammation Program, National Cancer Institute, US National Institutes of Health (NIH), Frederick, Maryland, USA
   Michael Dean & Michael L Nickerson
9. Guangdong and Shenzhen Key Laboratory of Male Reproductive Medicine and Genetics, Institute of Urology, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen, China
   Xianxin Li, Jingxiao Lu, Zhimao Jiang, Cailing Li, Jing Chen, Yongqi Lai, Zheguang Lin & Yaoting Gui
10. Department of Urology, The Second Xiangya Hospital of Central-Southern University, Changsha, China
    Xiaokun Zhao
11. Department of Urology, The First Affiliated Hospital of Anhui Medical University, Hefei, China
    Chaozhao Liang
12. Department of Urology, Zhujiang Hospital of Southern Medical University, Guangzhou, China
    Chunxiao Liu
13. Epithelial Cell Biology Research Center, School of Biomedical Sciences, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong, China
    Hsiao Chang Chan
14. BioMatrix, Rockville, Maryland, USA
    Shirley Tsang
15. Department of Surgery, University of Colorado Comprehensive Cancer Center, Aurora, Colorado, USA
    Dan Theodorescu
16. Department of Biology, University of Copenhagen, Copenhagen, Denmark
    Jun Wang
17. The Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark
    Jun Wang

Authors

1. Guangwu Guo
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2. Xiaojuan Sun
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3. Chao Chen
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4. Song Wu
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5. Peide Huang
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6. Zesong Li
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7. Michael Dean
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8. Yi Huang
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9. Wenlong Jia
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10. Quan Zhou
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11. Aifa Tang
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12. Zuoquan Yang
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13. Xianxin Li
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14. Pengfei Song
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15. Xiaokun Zhao
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16. Rui Ye
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17. Shiqiang Zhang
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18. Zhao Lin
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19. Mingfu Qi
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20. Shengqing Wan
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21. Liangfu Xie
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22. Fan Fan
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23. Michael L Nickerson
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24. Xiangjun Zou
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25. Xueda Hu
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26. Li Xing
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27. Zhaojie Lv
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28. Hongbin Mei
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29. Shengjie Gao
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30. Chaozhao Liang
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31. Zhibo Gao
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32. Jingxiao Lu
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33. Yuan Yu
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34. Chunxiao Liu
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35. Lin Li
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36. Xiaodong Fang
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37. Zhimao Jiang
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38. Jie Yang
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39. Cailing Li
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40. Xin Zhao
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41. Jing Chen
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42. Fang Zhang
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43. Yongqi Lai
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44. Zheguang Lin
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45. Fangjian Zhou
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46. Hao Chen
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47. Hsiao Chang Chan
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48. Shirley Tsang
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49. Dan Theodorescu
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50. Yingrui Li
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51. Xiuqing Zhang
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52. Jian Wang
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53. Huanming Yang
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54. Yaoting Gui
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55. Jun Wang
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56. Zhiming Cai
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Contributions

Jun Wang, Z.C., Jian Wang, H.Y., Y. Li, X. Zhang and Y.G. managed the project. X.S., S. Wu, Z. Li, A.T., X.L., Xiaokun Zhao, S.Z., M.Q., L. Xie, X. Zou, L. Xing, Z. Lv, H.M., C. Liang, J.L., C. Liu, C. Li, J.C., Y. Lai, Zheguang Lin and F. Zhou prepared the samples. P.H., P.S., F.F., Y.Y. and Xin Zhao performed the sequencing. G.G., C.C., Y.H., W.J., Q.Z., Z.Y., R.Y., Zhao Lin, S. Wan, M.L.N., M.D., S.G., Z.G., L.L., X.F., J.Y., F. Zhang, S.T. and D.T. performed the bioinformatic analysis. X.S., P.H., Z. Li, P.S., F.F., X.H., Z.J., H.C. and H.C.C. performed the validation of somatic mutations, CNAs and gene fusion events. G.G. wrote the manuscript. G.G., X.S., C.C., S. Wu, P.H. and Z. Li revised the manuscript.

Corresponding authors

Correspondence toYaoting Gui, Jun Wang or Zhiming Cai.

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The authors declare no competing financial interests.

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Guo, G., Sun, X., Chen, C. et al. Whole-genome and whole-exome sequencing of bladder cancer identifies frequent alterations in genes involved in sister chromatid cohesion and segregation.Nat Genet 45, 1459–1463 (2013). https://doi.org/10.1038/ng.2798

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• Received: 15 January 2013
• Accepted: 16 September 2013
• Published: 13 October 2013
• Issue Date: December 2013
• DOI: https://doi.org/10.1038/ng.2798