RNF43 is frequently mutated in colorectal and endometrial cancers (original) (raw)

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Acknowledgements

We thank S. Bahl, E. Nickerson and S. Chauvin for project management and A. Regev for help with computing resources, as well as A. Sivachenko, F. Huang and P. Tamayo for helpful discussions. This work was supported by the Dana-Farber Cancer Institute Leadership Council, the 2014 Colon Cancer Alliance–American Association for Cancer Research Fellowship for Biomarker Research, grant 14-40-40-GIAN, the Perry S. Levy Endowed Fellowship (M.G.), award T32GM007753 from the National Institute of General Medical Sciences, the Herchel Smith Fellowship (E.H.) and the Agrusa Fund for Colorectal Cancer Research (C.S.F.), as well as National Human Genome Research Institute grant U54HG003067 (E.S.L. and S.B.G.) and National Cancer Institute grants, K07CA190673 (R.N.), P01CA87969, UM1CA167552 and R01CA151993 (S.O.), R01CA118553 and R01CA168141 (C.S.F.) and P50CA127003 (M.G., W.C.H., L.A.G. and C.S.F.).

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Author notes

  1. Marios Giannakis and Eran Hodis: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts, USA
    Marios Giannakis, Eran Hodis, Xinmeng Jasmine Mu, Mai Yamauchi, Joseph Rosenbluh, Zhi Rong Qian, Reiko Nishihara, Eliezer M Van Allen, William C Hahn, Shuji Ogino, Charles S Fuchs & Levi A Garraway
  2. Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Marios Giannakis, Eliezer M Van Allen, William C Hahn & Levi A Garraway
  3. Broad Institute of MIT and Harvard, Cambridge, Massachusetts, USA
    Marios Giannakis, Eran Hodis, Xinmeng Jasmine Mu, Joseph Rosenbluh, Kristian Cibulskis, Gordon Saksena, Michael S Lawrence, Eliezer M Van Allen, William C Hahn, Stacey B Gabriel, Eric S Lander, Gad Getz & Levi A Garraway
  4. Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Eran Hodis
  5. Biophysics Program, Harvard University, Cambridge, Massachusetts, USA
    Eran Hodis
  6. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Reiko Nishihara & Shuji Ogino
  7. Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
    Reiko Nishihara
  8. Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
    Reiko Nishihara
  9. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
    Eric S Lander
  10. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts, USA
    Eric S Lander
  11. Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts, USA
    Gad Getz
  12. Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Shuji Ogino
  13. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
    Charles S Fuchs

Authors

  1. Marios Giannakis
  2. Eran Hodis
  3. Xinmeng Jasmine Mu
  4. Mai Yamauchi
  5. Joseph Rosenbluh
  6. Kristian Cibulskis
  7. Gordon Saksena
  8. Michael S Lawrence
  9. Zhi Rong Qian
  10. Reiko Nishihara
  11. Eliezer M Van Allen
  12. William C Hahn
  13. Stacey B Gabriel
  14. Eric S Lander
  15. Gad Getz
  16. Shuji Ogino
  17. Charles S Fuchs
  18. Levi A Garraway

Contributions

M.G., E.H., W.C.H., G.G., S.B.G., E.S.L., S.O., C.S.F. and L.A.G. designed research. M.G., E.H., X.J.M., M.Y., J.R., K.C., G.S., M.S.L., Z.R.Q., R.N. and E.M.V.A. performed research. G.G., S.B.G., E.S.L., S.O. and C.S.F. contributed new reagents and analytic tools. M.G., E.H., X.J.M., E.M.V.A. and L.A.G. analyzed data. M.G., E.H. and L.A.G. wrote the manuscript.

Corresponding author

Correspondence toLevi A Garraway.

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Competing interests

L.A.G. is a consultant for an equity holder in Foundation Medicine. L.A.G. is also a consultant to Novartis, Millenium/Takeda and Boehringer Ingelheim and is a recipient of a grant from Novartis.

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Giannakis, M., Hodis, E., Jasmine Mu, X. et al. RNF43 is frequently mutated in colorectal and endometrial cancers.Nat Genet 46, 1264–1266 (2014). https://doi.org/10.1038/ng.3127

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